Navigation Links
Study finds a new culprit for epileptic seizures
Date:1/16/2013

CAMBRIGDE, MA -- Epileptic seizures occur when neurons in the brain become excessively active. However, a new study from MIT neuroscientists suggests that some seizures may originate in non-neuronal cells known as glia, which were long believed to play a mere supporting role in brain function.

In a study of fruit flies, the researchers identified a glial-cell mutation that makes the flies much more prone to epileptic seizures. Mutations in the gene, which influences glial cells' communication with neurons, appear to make neurons much more excitable. That excitability makes the flies more likely to seize in response to environmental stimuli, such as extreme temperatures.

This is the first time anyone has shown, in living animals, that mutations in glial cells can produce epileptic seizures. Counteracting the effects of the glial mutation may be a promising new strategy for developing epilepsy treatments, says Troy Littleton, an MIT professor of biology and leader of the research team.

"This signaling pathway from glia to neurons likely controls the firing properties of neurons, and if it's hyperactivated, the neurons fire too much. Anything that would prevent that hyperactivity might be a potential therapeutic," says Littleton, who is also a member of MIT's Picower Institute for Learning and Memory.

Littleton and lead author Jan Melom, a graduate student in MIT's Department of Biology, described their new findings in the Jan. 16 online edition of the Journal for Neuroscience.

Origin of seizures

Glial cells, which make up about half of the cells in the brain, have many supporting roles, including cushioning neurons and helping them form connections with one another. However, in recent years, neuroscientists have found evidence of more important functions, such as assisting in communication between neurons.

Previous studies had shown that glial cells become hyperactive during epileptic
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researcher awarded $5.08 million to study oilseed camelina as biofuel feedstock
2. International study: Where theres smoke or smog, theres climate change
3. Born to lead? Leadership can be an inherited trait, study finds
4. CU-led study shows pine beetle outbreak buffers watersheds from nitrate pollution
5. UCI study reveals why Down syndrome boosts susceptibility to other conditions
6. Multiple sclerosis study reveals how killer T cells learn to recognize nerve fiber insulators
7. UC Davis study deflates notion that pear-shaped bodies more healthy than apples
8. Rhythms in the brain help give a sense of location, study shows
9. Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
10. New study identifies significance of co-infection in disease control
11. Study finds Jurassic ecosystems were similar to modern: Animals flourish among lush plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and ... the addition of the "iPhone 5S Fingerprint ... Report" report to their offering. ... the acquisition of AuthenTec in July 2012, Apple ... 5S. It is currently the only device of ...
(Date:12/19/2014)... 18, 2014   LaunchKey , the first decentralized ... and Internet of Things era, today announced the close ... round was led by Metamorphic Ventures with participation from ... VegasTechFund, and others.  LaunchKey has raised $4 million to ... its team and bring LaunchKey to market in 2015. ...
(Date:12/17/2014)... , Dec. 15, 2014  HITLAB SM ... Clinical Practices (GCP) audit to confirm its adherence ... regulations. This accomplishment enables HITLAB to conduct regulated ... the highest principles for patient safety and research ... global healthcare access, quality, and delivery with innovative ...
Breaking Biology News(10 mins):iPhone 5S Fingerprint Sensor - Apple/AuthenTec TMDR92 & Sapphire - Technology Report 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2
... 1st issue of G&D, Drs. Yong Sun Lee and Anindya ... in vitro. , "Overexpression of HMGA2 is an important ... Dutta. “It is very exciting to realize that microRNAs have ... so may have a role in the causation and perhaps ...
... blockbuster "Finding Nemo" when a school of fish makes a rapid ... other intricate designs. While the detailed shapes might be a bit ... how does a school of fish or a flock of birds ... reorganize as a unit, without knowing what the entire group is ...
... K. Long, MD, an endocrinology research fellow at the ... California, San Francisco, was one of only three scientists ... the National Space Biomedical Research Institute (NSBRI). , Long's ... possible methods of treating or preventing bone loss resulting ...
Cached Biology News:University of Alberta researchers unravel intricate animal patterns 2University of Alberta researchers unravel intricate animal patterns 3Researcher to study astronaut bone loss for space biology agency 2Researcher to study astronaut bone loss for space biology agency 3
(Date:12/24/2014)... (PRWEB) December 24, 2014 The report ... at 19.7% by 2019. It also provides a carefully ... strategies and challenges for the market. , Full Copy ... the report, the global market for cell expansion will ... future. It expects this growth to be driven by ...
(Date:12/24/2014)... , December 23, 2014 PharmaBoardroom,s ... , out today and available for free download , ... driving change and growth in the sector today. ... notable successes has been in developing a homegrown pharmaceutical manufacturing ... local production still remains some way off. A cursory comparison ...
(Date:12/22/2014)... Brussels (PRWEB) December 22, 2014 The ... the global leader of technical training across the life ... Clinical Data Management (SCDM) to provide the organization's ... certification programs —providing access to the more than 350 ... SCDM members with 10% off when registering for a ...
(Date:12/22/2014)... 22, 2014 GenomeDx Biosciences today announced that ... Classifier, a genomic test for prostate cancer, was able ... managed by radical prostatectomy without adjuvant therapy. Although rapid ... uncommon, using tumor genomics to identify these men who ... an important advance. The study has been published ...
Breaking Biology Technology:The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3
... ... distribution partner for the Taiwanese market. Uni-Onward,s recent focus on USP/NF grade chemicals is ... lab chemicals distributor in Taiwan and has built an outstanding reputation since its establishment ... ...
... Researchers from Rensselaer Polytechnic Institute have developed a ... strength of infrared imaging and could lead to a ... By leveraging the unique properties of nanoscale gold ... of the device, the researchers have doubled the detectivity ...
... OriGene Technologies, Inc. with the support of Wuxi Biopharmaceutical R&D ... and most sophisticated monoclonal antibody production centers in the world in Wuxi, ... have over one thousand employees with the capacity to produce over 20,000 ... , ...
Cached Biology Technology:Spectrum Announces Uni-Onward as its Taiwanese Distributor 2Nanotech discovery at Rensselaer could lead to breakthrough in infrared satellite imaging technology 2Nanotech discovery at Rensselaer could lead to breakthrough in infrared satellite imaging technology 3OriGene Technologies, Inc. to Build the World's Largest TrueMAB(TM) Monoclonal Antibody Facility in Wuxi, China 2
... Gelzyme is an agarose-digesting enzyme ... cleaves simple carbohydrate bonds in agarose ... longer gel. The remaining carbohydrate molecules ... manipulation. DNA isolated with Gelzyme enzyme ...
RAT ANTI MOUSE METALLOPHILIC MACROPHAGES...
S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
Form: Ready to use Applications: ELISA...
Biology Products: