Navigation Links
Study finds 'Western diet' detrimental to fetal hippocampal tissue transplants
Date:4/23/2012

es for successfully grafting cells," said Dr. Freeman. "The causes for this are unclear, but factors such as the inflammatory response, reduced growth factor production and reduced cellular support systems have been explored."

The researchers grafted developing hippocampal tissue to middle-aged recipient rats knowing that the grafts may be compromised by increased systemic cytokines and that the HFHC diet would be further detrimental.

After six weeks, the researchers found stunted growth in fetal hippocampal tissues among the animals fed the HFHC diet as opposed to normal development in controls receiving a normal diet. However, when treated topically with IL-1Ra, the HFHC fed animals grew grafts three times the size of HFHC-fed, saline-treated controls.

"All factors taken together, the HFHC diet was shown to exert detrimental effects on hippocampal growth and development," explained Dr. Freeman. "Factors contributing to this effect include, but are not limited to, vascularization and inflammation."

The research team concluded that not only was graft growth altered by the HFHC diet, but that neuronal development and organization was affected as well. However, that treatment with IL-1Ra blocked the detrimental effects of the HFHC diet on hippocampal tissues may indicate a potential use for IL-1Ra in neurological disorders involving neuroinflammation.

"Eight weeks on a Westernized high fat high cholesterol diet causes developmental neuroinflammation in middle-aged rats that can be reversed by an interleukin-1 receptor antagonist" said Dr. John Sladek, professor of neurology and pediatrics at the University of Colorado School of Medicine. "It will be interesting to see if the interleukin-1 receptor antagonist is still effective with a long term Westernized diet and whether this can be translated to humans."
'/>"/>

Contact: David Eve
celltransplantation@gmail.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2

Related biology news :

1. Women & Infants participating in study of treatment of common viral infection in pregnancy
2. Study finds soda consumption increases overall stroke risk
3. Study finds cancer-fighting goodness in cholesterol
4. New study links air pollution and early death in the UK
5. Effect of chronic exposure to chemicals used as weapons, pesticides under study
6. NIST/UMass study finds evidence nanoparticles may increase plant DNA damage
7. Jellyfish on the rise: UBC study
8. Improved loblolly pines better for the environment, study finds
9. Study amplifies understanding of hearing in baleen whales
10. Large international study finds memory in adults impacted by versions of 4 genes
11. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... source of a unique rhythmic sound, recorded for decades ... the Antarctic minke whale ( Balaenoptera bonaerensis ). First ... who thought it sounded like a duck, the bio-duck ... Southern Ocean, but its source has remained a mystery, ... of researchers deployed acoustic tags on two Antarctic minke ...
(Date:4/23/2014)... gas boom has transformed the energy landscape in ... could cause conflict among the energy industry, residents ... researchers. They add that degraded water quality is ... The feature article appears in the ACS journal ... S. Mauter and colleagues point out that a ...
(Date:4/23/2014)... Heidelberg, 23 April 2013 EMBO today announced Sophie ... winner of the 2014 EMBO Gold Medal. The award ... define the organization and development of the cell. , ... to understand cellular polarity, in particular the way in ... size and cell division. In the last 11 years, ...
Breaking Biology News(10 mins):Scientists identify source of mysterious sound in the Southern Ocean 2Scientists identify source of mysterious sound in the Southern Ocean 3How to avoid water wars between 'fracking' industry and residents 2EMBO Gold Medal 2014 awarded to Sophie Martin 2
... , , , , ... AUDIO: Falon Tilley and Michael W. Beets discuss the successful implementation of ... Click here for more information. , , ... , , , , , ...
... by Jonathan Waxman is a collection of short stories that ... a doctor,s life before the dawn of management. Written in ... from the author,s decades of clinical experience. Chutney Wars, The ... a few of the chapters in this engagingly written book. ...
... have been awarded fellowships from the Alfred P. ... NYU,s Center for Neural Science, and Nicholas Stavropoulos, ... NYU Langone Medical Center and its Neuroscience Institute. ... and scholars "whose achievements and potential identify them ...
Cached Biology News:Healthy Lunchbox Challenge helps influence healthy eating habits in children 2Healthy Lunchbox Challenge helps influence healthy eating habits in children 3Healthy Lunchbox Challenge helps influence healthy eating habits in children 4Two NYU faculty win Sloan Foundation research fellowships 2
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... conjugates for cancer, today announced the appointment of Thomas C ... has over 20 years, development experience gained in the biotechnology ... "I am delighted to welcome Tom at this ...
(Date:1/15/2014)... Houston, TX (PRWEB) January 15, 2014 ... Alzheimer’s disease, and about 1 in 3 seniors will ... ( source ). These jaw-dropping figures have shocked many ... function and, hopefully, help prevent these tragic age-related cognitive ...
(Date:1/15/2014)... January 15, 2014 2013 was a ... Brain State Technologies®. They saw continued independent research led ... who were awarded a $1 million grant from the ... “Brain and Behavior” a peer reviewed journal, Amy Grant ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 p.m. ... Road, Warrington, Pa. , Details: The Hepatitis B ... a cure for hepatitis B and improving the quality of ... Ball on Friday, April 11 at Warrington Country Club in ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... / Electroporator 2510 , , , , , , , ... Protocol No. 4308 915.521 02/2002 , , , , ... , Microorganism , Mycobacterium intracellulare ... type , Bacteria, gram positive, , ...
... , , , , , , , ... Protocol No. 4308 915.046 11/2001 , , , , , ... , Cell line , L2, Schneider cells, Drosophila, ... pActin-SV-EGFP, , , ...
... , , , , , , Multiporator , , ... , Transfection Protocol , Protocol No. ... , , , , , ... cells (suspension cell line), , , ...
Cached Biology Technology:Mycobacterium intracellulare 2L2 2HL-60 2
For the quantitative determination of canine Interleukin 10,(IL-10) concentrations in cell culture supernates, canine serum,and plasma....
RAT ANTI RAT RT1Au (CLASS I POLYMORPHIC) Immunogen: AO lymphoid cells...
Human VEGF R Phycoerythrin Sampler (Cl 89106, 49560, 54733)...
MOUSE ANTI SIMIAN VIRUS 5:FITC Immunogen: Simian virus 5...
Biology Products: