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Study explores how life experiences contribute to the biological changes of Alzheimer's
Date:9/30/2009

-wide genotyping and epigenome wide scans.

Recent major advances in technology allow the scientists to look at one million genetic variations in a single human's DNA using a simple blood sample and tens of thousands of epigenomic marks across the genome with a small piece of brain tissue.

A third set of analyses will examine the relation of epigenetic marks to measures of the pathology of Alzheimer's disease, cerebrovascular disease and Lewy body disease found in the brain.

"Together, this integrative study represents a timely, novel and powerful approach that will transform our understanding of epigenetic contributions to age-related loss of cognition and dementia," said Bennett. "We are not aware of any other studies of older men and women of comparable size, relevant life experience, clinical data, and follow-up and autopsy rates, in which these analyses can be performed.


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Contact: Kim Waterman
Kimberly_Waterman@rush.edu
312-942-7820
Rush University Medical Center
Source:Eurekalert

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