Navigation Links
Study explores how life experiences contribute to the biological changes of Alzheimer's
Date:9/30/2009

o cognitive function in old age."

One of those factors may be epigenetic marks. There are currently about 30 known proteins that turn genes on and off. Since it is known that life experiences can affect which proteins are produced, Bennett and his colleagues want to know if the brain is using epigenetic marks as a means of linking experiential factors to long term memory storage.

"A memory trace involves protein production. It is hard to change genes, but it may be easier to manipulate the opening and closing of genes to impact memory," said Bennett.

Researchers will conduct epigenome-wide DNA methylation scans and epigenome-wide histone acetylation scans on brain tissue from participants in two large, longitudinal studies of aging and dementia: the Rush Memory and Aging Project and the Religious Orders Study. These studies include the participation of more than 2,400 older adults from across the country who have agreed to medical and psychological evaluation each year and brain donation after death. Brain tissue is already available from more than 750 participants, and the epigenomic studies will eventually examine brain tissue from more than 1000 participants.

The results of these scans will be used to explore the relation of epigenetic alterations to age-related cognitive decline and point to potential DNA methylation sites and histone modifications linking life experiences to cognitive decline and dementia. Understanding these relationships offer the possibility of therapeutic intervention because a number of drugs are known to affect epigenetic modifications.

In addition, Rush researchers have already been funded by the NIH to conduct a whole genome scan on participants from both studies. Thus, they will be able to examine the interaction between genetic variation and epigenetic marks on cognition and life experiences. Rush is collaborating with the Broad Institute of MIT and Harvard Universty to conduct the genome
'/>"/>

Contact: Kim Waterman
Kimberly_Waterman@rush.edu
312-942-7820
Rush University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... 2015  Synaptics Incorporated (NASDAQ: SYNA ), ... announced the appointment of Wajid Ali ... reporting to Rick Bergman , President and ... Officer, Kathleen Bayless , who announced her ... Ali brings extensive financial management expertise to Synaptics, ...
(Date:5/8/2015)... Synaptics Inc. (NASDAQ: SYNA ), the leading ... the executive management team will present at the following investor ... Telecom Conference Date: May 18, 2015 Time: 10:40am ... Cowen and Company Technology, Media & ... The New York Palace Hotel, New York, NY ...
(Date:4/27/2015)... , April 27, 2015  For more than ... trade show has been the premier worldwide event for ... 2015 is a must-attend event for any local, national, ... into the emerging commercial markets and current applications of ... innovations of this projected $48 billion industry, and how ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Synaptics to Present at Upcoming Investor Conferences 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
... A University of Oklahoma research team has been awarded ... a two-year option for $2.9 milliona five-year total of ... multidisciplinary university research initiative to assess the biological stability ... their impact on biocorrosion. Joseph M. Suflita, OU ...
... particulate matter is a type of contaminant in the ... conservation of materials and visibility. Chemist Ms Ainhoa Inza ... Autonomous Community of the Basque Country (CAV-EAE); concretely, the ... less than ten micras in diameter. Amongst other things, ...
... draw your blood, screen it for genetic mutations and chemical ... tailor-made for your DNA. That hypothetical drug would target ... over time that can lead to the formation of tumors ... tapped Viterbi professor Andrea Armani to develop a key instrument ...
Cached Biology News:Thesis studies atmospheric PM contaminant in the Basque Autonomous Community 2Fighting cancers by tagging their triggers 2
(Date:5/21/2015)... San Francisco, CA (PRWEB) May 21, 2015 ... microbiome sequencing, has announced a partnership with PicnicHealth, ... records for patients. Participants diagnosed with Inflammatory Bowel ... as well as a complementary uBiome research kit. ... Summer 2014. , For more ...
(Date:5/21/2015)... , May 21, 2015  CytRx Corporation (NASDAQ: ... company specializing in oncology, today announced positive updated ... with aldoxorubicin for the treatment of unresectable glioblastoma ...  The open-label, multisite trial is designed to investigate ... patients whose tumors have progressed following prior treatment ...
(Date:5/21/2015)... May 21, 2015 Tunnell Consulting, ... the firm as senior statistician and Principal, a position ... experience in the management and analysis of complex and ... chemical industries. , “We’re delighted to have Julia join ... data analytics,” said Dr. Philippe Cini, Group Vice President ...
(Date:5/20/2015)... Pa. , May 20, 2015  Select ... that the Federal Trade Commission granted early termination ... Antitrust Improvements Act of 1976, as amended, applicable ... MJ Acquisition Corporation, a joint venture that Select ... L.P. As previously announced, MJ Acquisition ...
Breaking Biology Technology:uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7Julia O’Neill Joins Tunnell Consulting’s Operational and Process Improvement Practice 2Select Medical Corporation's Proposed Acquisition of Concentra Inc. through Joint Venture with Welsh Carson Receives Antitrust Clearance 2
... from the term cloning, even with the controversial ethical connotations ... technique he developed to create Dolly the sheep will gain ... as human embryonic stem cell research has. , ,Wilmut, a ... at the University of Edinburgh, was in Madison to lecture ...
... a series of articles on raising capital from angel and ... Memorandums, or PPMs, and is co-written with Dan Ghoca. ... necessary to use a private placement memorandum (also referred to ... to angel investors in a private placement. Once we tell ...
... terms, a loss leader is merchandise sold below cost in ... on the shelves. A store owner might lose a few ... it handsomely through other sales. , ,Wisconsin's high-tech loss leader ... making much money - yet - on sales of stem-cell ...
Cached Biology Technology:Biologist who cloned Dolly the sheep believes therapeutic cloning will gain acceptance 2Biologist who cloned Dolly the sheep believes therapeutic cloning will gain acceptance 3Biologist who cloned Dolly the sheep believes therapeutic cloning will gain acceptance 4When raising capital, why use a Private Placement Memorandum? 2When raising capital, why use a Private Placement Memorandum? 3When raising capital, why use a Private Placement Memorandum? 4When raising capital, why use a Private Placement Memorandum? 5Stem cells get most attention, but they are only part of Wisconsin's bio-portfolio 2Stem cells get most attention, but they are only part of Wisconsin's bio-portfolio 3Stem cells get most attention, but they are only part of Wisconsin's bio-portfolio 4
Formula variant: With macro- and micronutrients. Physical Form: powder Suitab tst: plant cell culture tested...
... Ion Trap Time of Flight Mass Analyzer for superior sensitivity, mass ... 100 - 25,000 m/z, * Precursor ion selection range: 150 - ... accuracy: 5 ppm with internal reference, * Dynamic range: 4 orders ... ...
... The PHD2000 syringe pump series combines Harvard Apparatuss ... interface and a wide range of configuration options. ... the dimensions of syringes from all the major ... read all the pertinent information from across the ...
Mouse monoclonal antibody to RAD51L3 - RAD51-like 3 (S. cerevisiae)...
Biology Products: