Navigation Links
Study explores how life experiences contribute to the biological changes of Alzheimer's
Date:9/30/2009

o cognitive function in old age."

One of those factors may be epigenetic marks. There are currently about 30 known proteins that turn genes on and off. Since it is known that life experiences can affect which proteins are produced, Bennett and his colleagues want to know if the brain is using epigenetic marks as a means of linking experiential factors to long term memory storage.

"A memory trace involves protein production. It is hard to change genes, but it may be easier to manipulate the opening and closing of genes to impact memory," said Bennett.

Researchers will conduct epigenome-wide DNA methylation scans and epigenome-wide histone acetylation scans on brain tissue from participants in two large, longitudinal studies of aging and dementia: the Rush Memory and Aging Project and the Religious Orders Study. These studies include the participation of more than 2,400 older adults from across the country who have agreed to medical and psychological evaluation each year and brain donation after death. Brain tissue is already available from more than 750 participants, and the epigenomic studies will eventually examine brain tissue from more than 1000 participants.

The results of these scans will be used to explore the relation of epigenetic alterations to age-related cognitive decline and point to potential DNA methylation sites and histone modifications linking life experiences to cognitive decline and dementia. Understanding these relationships offer the possibility of therapeutic intervention because a number of drugs are known to affect epigenetic modifications.

In addition, Rush researchers have already been funded by the NIH to conduct a whole genome scan on participants from both studies. Thus, they will be able to examine the interaction between genetic variation and epigenetic marks on cognition and life experiences. Rush is collaborating with the Broad Institute of MIT and Harvard Universty to conduct the genome
'/>"/>

Contact: Kim Waterman
Kimberly_Waterman@rush.edu
312-942-7820
Rush University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... , Dec. 4, 2014  Tute Genomics, a ... $2.3 million in Series A1 funding led by UK-based ... also participated in the investment round. "We ... healthcare community adopts next-generation sequencing and seeks new approaches ... Reid Robison , MD MBA, and CEO of ...
(Date:11/21/2014)... , Nov. 19, 2014  Earlier this year ... York College, and one of the most prolific inventors ... that are transmitted from Smartphones to third party agencies. ... and has one of the earliest known patents in ... usage in the military, child care, elder care and ...
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... A team of cardiologists, materials scientists, and bioengineers ... device for measuring the heart,s electrical output that they ... new device represents the first use of flexible silicon ... believe that this technology may herald a new generation ...
... ngeles Mena, Researcher at Centro de Investigacin Biomdica ... of the Neuropharmacology Laboratory at Hospital Ramn y ... predoctoral student Juan Perucho and others. The ... changes and amyloid pathology of Alzheimer,s disease in ...
... PITTSBURGH, March 24 An experimental vaccine against an ... delay the onset of inflammatory bowel disease (IBD) and in ... the University of Pittsburgh School of Medicine. Their findings are ... journal of the American Association for Cancer Research. People ...
Cached Biology News:New tissue-hugging implant maps heart electrical activity in unprecedented detail 2New tissue-hugging implant maps heart electrical activity in unprecedented detail 3Anesthesia increases risk of developing Alzheimer's disease in patients with genetic predisposition 2Anesthesia increases risk of developing Alzheimer's disease in patients with genetic predisposition 3Vaccine could delay bowel inflammation and colon cancer, says Pitt research 2
(Date:12/22/2014)... 22, 2014 Fertility Associates of Memphis ... Bank USA , a network of more than 20 ... partnership, patients have fast access to a national pool ... IVF . Fertility Associates of Memphis is the only ... treatment option. , Dr. William Kutteh , director ...
(Date:12/19/2014)... Charm Sciences is pleased to announce that ... Aflatoxin M1 in raw commingled milk is the first ... The peer reviewed report of the validation by Technology ... and Fisheries Research (ILVO-T&V) has been published by the ... most toxic aflatoxin and a known carcinogen, can be ...
(Date:12/19/2014)... 2014 Naurex Inc., a biopharmaceutical company leveraging ... of the central nervous system, today announced that ... will present at the 33 rd annual J.P. ... at 3:00 p.m. PST on Tuesday, January 13, 2015, ... Francisco, Calif. About Naurex ...
(Date:12/19/2014)... Calif. , Dec. 19, 2014 Bina Technologies, ... USA) announced today that they have been acquired by ... is a privately held company that provides a ... next generation sequencing (NGS) data for the academic and ... Roche Sequencing Unit, and will continue to focus on ...
Breaking Biology Technology:Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... eResearchTechnology,Inc. (eRT), (Nasdaq: ERES ), a leading ... today that it will release its 2008 first ... on Monday, May 5,2008 after the market closes.,After ... call at 5:00 PM ET,later that day., ...
... - Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today ... St. James,s University Hospital in Leeds,U.K. published the ... May 1, 2008,online issue of The Journal of ... Cells to Promote Innate Antitumor Immunity.", The ...
... April 23 SectorWatch.biz announces the,availability of ... and driving,markets today within the biotechnology and ... the aforementioned equities and the,opportunity for investors ... the,subject and sector., Investors can view ...
Cached Biology Technology:eResearchTechnology, Inc. to Announce 2008 First Quarter Results on May 5, 2008 2Oncolytics Biotech Inc. Announces Journal of Immunology Publication on Reovirus Activation of Dendritic Cells 2SectorWatch.biz Issues MarketStats on KBLB, DGX, LH, BRLI, and ABT 2SectorWatch.biz Issues MarketStats on KBLB, DGX, LH, BRLI, and ABT 3
... is a two color staining method for ... to detect apoptotic cells by flow cytometry. ... required for measuring apoptosis in cells including: ... reagent performance; washing, reaction and rinsing buffers ...
... GT and PowerPac 3000 system, 220-240 V, is ... x 50 cm vertical slab gel format. The ... which is capable of separating nucleic acids with ... chamber (IPC) assembly (IPC and bonded inner glass ...
... PROTEAN Plus overlay agarose is ... to secure IPG strips in place ... tracking dye is incorporated to allow ... is composed of 0.75% agarose in ...
... PowerPac HV high-voltage power supply, with temperature probe, ... of 5,000 V, 500 mA, and 400 W. ... temperature between 0 and 90 degrees C during ... transfer. Power cord and instructions are provided. Dimensions ...
Biology Products: