Navigation Links
Study explores how life experiences contribute to the biological changes of Alzheimer's
Date:9/30/2009

The National Institutes of Health has awarded Rush University Medical Center approximately $5.5 million in grants to study how epigenetic changes chemical modifications to genes that result from diet, aging, stress, or environmental exposures define and contribute to memory formation and cognitive decline. Results from the studies could profoundly alter the way the medical community understands, diagnoses, and treats Alzheimer's disease, according to the researchers.

Every cell in the body has the same genetic information. What makes cells, tissues and organs different are the epigenetic modifications, or marks, that turn genes on or off.

Researchers at the Rush Alzheimer's Disease Center hypothesize that the brain uses epigenetic marks to store memory and are exploring the relationship between life experiences known to affect memory abilities and changes in the epigenetic marks.

The study is motivated, in large part, from the center's work with two large, longitudinal studies of aging and dementia conducted over the past 15 years. Researchers at Rush have identified a wide range of life experiences that are related to loss of cognitive function and a clinical diagnosis of Alzheimer's disease but are not associated with the neuropathologic hallmarks of the disease, the plaques and tangles that accumulate in the brain. These life experiences include socioeconomic status, psychological distress, and cognitive, physical, and social activities across the life span.

"We have found that while cognitive decline in old age often results from one or more of three common brain diseases, Alzheimer's disease, cerebrovascular disease and Lewy body disease, these conditions only account for about 20% of the variance of cognition in older persons," said Dr. David Bennett, director of the Rush Alzheimer's Disease Center and principal investigator for the studies. "Thus, factors other than neuropathology must make important contributions t
'/>"/>

Contact: Kim Waterman
Kimberly_Waterman@rush.edu
312-942-7820
Rush University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)...  HYPR Corp. today announced it has joined ... tm , an industry consortium transforming online authentication ... technology and collaborate to deliver open specifications for ... and private, and easier to use. ... sensitive user information and eliminates the dependency on ...
(Date:4/10/2015)... 10, 2015 Research and Markets ... "Security Competitive Profiles - NEC" report to ... NEC will continue to supply a range of ... with a company focus on the development of a ... Winning opportunities in the Asia-Pacific ...
(Date:4/2/2015)... In the current eight ... the strongest competitors, showing outstanding performance in recognition ... is capable of a throughput of 5.000.000 fingerprints ... be ten times faster than most competitors and ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) , ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NEC Security Competitive Profile 2015 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... , LAS VEGAS , April 27 In its third ... open to a more inclusive pool of contestants and takes place three times ... Championship) invites any company with tea inventory in North America to ... harvests of hot tea, as well as iced tea. , ...
... April 27 From international jetsetter to model to entrepreneur, ... resume as she unveils her debut collection for QVC. The Slovenian beauty is scheduled ... PM (ET) to debut the Melania™ Timepieces & Fashion Jewelry line ... , , ...
... with a volume equivalent to 40 Amazon Rivers has been ... in the Indian Ocean sector of the Southern Ocean, 4200 ... Nature Geoscience , the researchers described the current more ... important pathway in a global network of ocean currents that ...
Cached Biology News:World Tea Expo Throws Open Door to Tea Championship 2Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 2Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 3Melania Trump Takes 'Time' To Shine With New QVC(R) Collection 4Massive Southern Ocean current discovered 2
(Date:4/30/2015)... 2015 WuXi PharmaTech (Cayman) Inc. ("WuXi" or ... contract R&D services provider, today announced that its board ... dated April 29, 2015, from a consortium (the "Consortium") ... founder, chairman and chief executive officer of the Company, ... a transaction (the "Transaction") involving the acquisition of all ...
(Date:4/30/2015)... SureClinical, a leader in cloud-based health science ... SureClinical’s executive team as Chief Financial Officer. ... with over 25 years in leadership roles ranging from ... Morris joins SureClinical from Marrone Bio Innovations (MBI), a ... MBI from its founding in 2006 until 2011, when ...
(Date:4/29/2015)... 30, 2015 According to a ... by Product (Portable & Non-Portable), Component (Accelerometer, Proximity ... Chemical, Metal & Mining, & Others), & Geography ... is expected to reach $1,453.76 Million by 2020, ... market data tables and 92 figures spread through ...
(Date:4/29/2015)... 2015   Doximity , the leading online medical ... as members, announced a new, instant method for physicians ... With one click, all US physicians can quickly submit ... for an open job opportunity, and a recruiter will ... seven percent of physicians are open to new jobs, ...
Breaking Biology Technology:WuXi PharmaTech Announces Receipt of Proposal 2WuXi PharmaTech Announces Receipt of Proposal 3WuXi PharmaTech Announces Receipt of Proposal 4WuXi PharmaTech Announces Receipt of Proposal 5WuXi PharmaTech Announces Receipt of Proposal 6Julie I. Morris Joins SureClinical as Chief Financial Officer 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 2Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 3Vibration Monitoring Equipment (Portable & Non-Portable) Market worth $1,453.76 Million by 2020 - New Report by MarketsandMarkets 4Doximity Offering Hospitals Easy, Efficient Physician Application Tool 2
... Wash.The world,s biggest Roman candle has got nothing on ... in the Earth or on a giant planet, Washington ... capable of storing vast amounts of energy. "If you ... of energy storage outside of nuclear energy," says Choong-Shik ...
... engineering school in Grenoble, France, and Virginia Tech is ... The students, work will help gene synthesis companies and ... DNA as harmful agents for bioterrorism. Synthetic biology ... production, agriculture, and other areas. For a few thousand ...
... Nanoscience has garnered billions of dollars of funding and ... Revolution. But, for such a richly anticipated field, ... us from odor-eating socks to cosmetics and medications ... with visions of nanotechnology as cornucopia or Armageddon. ...
Cached Biology Technology:iGEM team helps prevent rogue use of synthetic biology 2New resource examines questions about the role of nanoscience 2
... Rabbit polyclonal to BMP2 ... factor beta (TGFB) superfamily. Bone morphogenic ... a candidate gene for the autosomal ... progressiva. Immunogen: Synthetic ...
The Microseal 384 plate positioner ensures precise positioning of Microseal 384-well plates in the x-, y-, and z-dimensions, for accurate automated liquid handling....
...
... manual heat sealer ideal for low to medium ... seal a wide range of plates of differing ... element of the sealer is pre-set for optimal ... when used in conjunction with ABgenes sealing foil ...
Biology Products: