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Study explains why men are at higher risk for stomach cancer
Date:7/13/2011

against gastric cancer, the MIT researchers examined which genes were overexpressed in the treated mice. They identified about 60 genes, most of which are involved in cell movement and/or cancer growth. Of these candidates, they decided to focus on CXCL1, a signaling protein that is involved in cell movement and recruitment of immune cells.

The human analogue of CXCL1 is IL-8, which is often part of the immune response to H. pylori. The researchers believe that chronic H. pylori infection stimulates production of CXCL1 (or IL-8 in humans), which attracts immune cells such as neutrophils and macrophages. This promotes inflammation, eventually leading to gastritis and cancer.

Estrogen somehow interferes with the recruitment or activity of those immune cells. The researchers are now trying to figure out in more detail how this happens, by studying mice that are missing the gene for CXCL1. They are also interested in developing molecules that inhibit CXCL1 activity.


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Contact: Marta Buczek
mbuczek@mit.edu
617-721-5749
Massachusetts Institute of Technology
Source:Eurekalert

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