Navigation Links
Study explains potential failure of oral contraceptives with obese women
Date:7/14/2009

e pharmacokinetics, or way drugs act and are processed in the body. There's a growing awareness that we need to more carefully consider obesity and other factors that affect drug absorption, distribution, metabolism and other factors."

Conventional oral contraceptives, Cherala said, are thought to be relatively "lipophilic," or tend to concentrate in fat tissue. However, the researchers in this study said they were somewhat surprised to find that the affinity of these drugs for fat tissue was not significantly different between obese and normal body weight subjects.

Rather, the researchers found that contraceptive drug levels in both obese women and those of normal weight eventually were about the same, but it took longer to achieve that level in very overweight women.

The study showed it took an average of about five days for the drugs to achieve their maximum concentration in women of normal weight, an average of 10 days for obese women, and even longer than that for some individuals. One woman in the study took more than 20 days to reach a "steady state" drug concentration. Women of normal weight who follow their oral contraceptive directions should have appropriate protection against pregnancy. But the delay in reaching a steady state drug concentration raises questions about how well oral contraceptives may work for obese women.

Increasing the drug dosage might help address this issue, Cherala said, but also adds other health concerns.

In fact, the researchers noted in their report that many clinicians actually prescribe lower-dose oral contraceptives to obese patients in an effort to decrease their risk of venous thrombosis. These are blood clots in the legs or elsewhere that can increase the risk of stroke and heart attacks.

The study was done with 20 women of ages 18 to 35, all of them healthy and seeking contraception, 10 of whom were of normal weight and 10 with a "body mass index" of more than 30
'/>"/>

Contact: Ganesh Cherala
cherala@ohsu.edu
503-418-0447
Oregon State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by NTU professors provides important insight into apoptosis or programmed cell death
2. Probiotics help gastric-bypass patients lose weight more quickly, Stanford study shows
3. New study ranks hotspots of human impact on coastal areas
4. Work in mice will contribute to the study of hereditary diseases that lead to blindness
5. UAB study reveals bone coupling factor key to skeletal health
6. Army study improves ability to predict drinking water needs
7. Plant protein doorkeepers block invading microbes, study finds
8. Study finds role for parasites in evolution of sex
9. Canadian researchers set to study impact of nanomaterials on aquatic ecosystems
10. MS study offers theory for why repair of brains wiring fails
11. Oscar Pistorius: Previously confidential study results released on amputee sprinter
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition of the ... report to their offering. This report analyzes the worldwide ... following Segments: Face Biometrics, and Voice Biometrics. The report provides separate ... Japan , Europe , ... Africa , and Latin America . ...
(Date:3/23/2015)...  In the 2014 fiscal year, irs.gov recorded over ... figure accounts for a fraction of the estimated losses ... exceeds $11 billion globally. The polygraph has traditionally been ... occurred. Investor Mark Saint Juste along with ... partnered to administer the test in a new ...
(Date:3/20/2015)... Mar. 19, 2015 Research and Markets ( ... Biometrics - Global Strategic Business Report" report to their ... Iris Biometrics in US$ Thousands. The report provides separate comprehensive ... Japan , Europe , ... and Latin America . Annual ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... found that pre-existing malaria prevents secondary infection by another ... iron availability in the liver of the host. This ... Nature Medicine and has important implications for ... affects millions of individuals worldwide. The study was ...
... a class of compounds that could be a boon to ... study, published online in Nature Chemical Biology on ... and selectively block the activity of a large and diverse ... hydrolase-blocking compounds have been turned into drugs to treat obesity, ...
... May 15, 2011) An international research team ... Institute for Breast Cancer Research at Princess Margaret Hospital ... the process whereby tumour cells adapt and survive under ... published today in Genes and Development ( ...
Cached Biology News:Malaria against malaria: A pre-existing malaria infection can prevent a second infection 2Malaria against malaria: A pre-existing malaria infection can prevent a second infection 3Scientists find new class of compounds with great potential for research and drug development 2Scientists find new class of compounds with great potential for research and drug development 3Cancer scientists discover new way breast cancer cells adapt to environmental stress 2
(Date:4/24/2015)... Telbec/ - Mirego, leader in mobile strategies and solutions, is ... app extensions for the all new Apple Watch. Made in ... and MediaMiser, these extensions will reinvent the way users receive ... wrist use.  Available today in ... tactile smartwatch that makes for an excellent buddy for business, ...
(Date:4/24/2015)... 2015 Seoul Semiconductor announced the ... applications in the lighting market. In recent ... this technology in emerging markets such as Russia, ... range of applications such as streetlight and area ... , First launched in 2005 the Acrich technology ...
(Date:4/23/2015)... Mount Dora, Florida (PRWEB) April 23, 2015 ... announced that it intends to conduct a groundbreaking ... can begin to be reversed in as little ... researchers—using the science of metabolic and nutritional medicine—will ... conditions that cripple and destroy our aging brain. ...
(Date:4/23/2015)... 2015 Six startups from Russia ... 4-17 as part of the U.S.-Russia Innovation Corridor ... of biotechnology startups to participate in the program ... and the University of Maryland (UMD) signed a ... respective universities in the biomedical industry in 2013. ...
Breaking Biology Technology:Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 2U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 3U.S.-Russian Innovation Corridor Program Connects Visiting Russian Startups to U.S. Experts 4
... 20 Humanitarian, Dr. Gary Michelson,is "making an ... Gilbreath, Executive Director of Found Animals Foundation (Found,Animals) ... Found Animals and its strategic partner the Alliance ... launch of The Michelson Prize in,Reproductive Biology at ...
... The Board of Directors,of Eli Lilly and Company ... as a,new member, effective December 1, 2008. Oberhelman, 55, ... is a member of Caterpillar,s,executive office. As a member ... audit committee and finance committee. He will stand for,election ...
... ORANGE COUNTY, Calif., Oct. 20 Beckman,Coulter, Inc. ... Board of Directors,declared a quarterly dividend payout of ... payable on November 17, 2008 to all,stockholders of ... the 78th,consecutive, quarterly payout of dividends., (Logo: ...
Cached Biology Technology:Humanitarian Offers $75 Million for Single Dose Sterilization of Cats and Dogs 2Humanitarian Offers $75 Million for Single Dose Sterilization of Cats and Dogs 3Humanitarian Offers $75 Million for Single Dose Sterilization of Cats and Dogs 4Douglas Oberhelman Elected to Lilly Board of Directors 2Douglas Oberhelman Elected to Lilly Board of Directors 3
...
Chicken anti-EEA1...
... Cell Dissociation Buffers are membrane-filtered ... salts chelating agents and cell-conditioning agents ... balanced salt solution or Ca2+- ... dissociation of mammalian cells from support ...
Request Info...
Biology Products: