Navigation Links
Study explaining parasite gene expression could help fight toxoplasmosis and malaria
Date:1/2/2014

INDIANAPOLIS -- A newly identified protein and other proteins it interacts with could become effective targets for new drugs to control the parasite that cause toxoplasmosis, researchers led by investigators at Indiana University School of Medicine have reported.

The discovery could also open new research pathways for treatments for malaria.

The researchers determined that the protein, an enzyme called GCN5b, is necessary for the Toxoplasma parasite to replicate, so interfering with its activities could control the parasite. GCN5b is part of the molecular machinery that turns genes on and off in the parasite, working with other proteins that, the researchers discovered, are more plant-like than their counterparts in humans.

"GCN5b is a very different protein than its human counterpart, and proteins it interacts with are not found in humans," said William J. Sullivan Jr., Ph.D., associate professor of pharmacology and toxicology.

"That's what makes this exciting -- rather than just having one enzyme that we could go after, there could be a whole collection of associated enzyme components that could be potentially targeted for drug therapies to control this parasite," he said.

In discovering that some of the proteins interacting with GCN5b are plant-like transcription factors -- proteins that bind to DNA -- the researchers filled in what had been a missing link explaining how the parasites control the process of turning genes on and off, known as gene expression. The plant-like transcription factors recruit the GCN5b enzyme complex to activate a wide variety of genes for expression.

When the research team disabled the GCN5b complex, parasite replication swiftly came to a halt.

Dr. Sullivan and his colleagues reported their findings in the Jan. 2, 2014, online edition of the journal PLOS Pathogens.

An estimated 60 million people in the United States are infected with the toxo
'/>"/>

Contact: Eric Schoch
eschoch@iu.edu
317-274-8205
Indiana University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Montana State University research on algal biofuels keys larger study
2. Study finds patients give broad endorsement to stem cell research
3. Ill have what theyre having: Study finds social norms influence food choices
4. UTSW study identifies potential therapeutic target for incurable, rare type of soft-tissue cancer
5. International team completes systematic, genomic study of cervical cancer
6. Study finds axon regeneration after Schwann cell graft to injured spinal cord
7. Slippery bark protects trees from pine beetle attack, according to CU-Boulder study
8. Study offers clues to how plants evolved to cope with cold
9. Study shows Where Alzheimers starts and how it spreads
10. Study: Some plants may not adapt quickly to future climate change
11. Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study explaining parasite gene expression could help fight toxoplasmosis and malaria
(Date:12/11/2014)... Dec. 09, 2014 Research and Markets ... http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition of the ... offering. One major trend emerging in ... Multimodal biometric systems utilize more than one characteristic of ...
(Date:12/10/2014)... You,ve been here before: you desperately need to sign into your ... the answer to your secret question. What,s your dog,s birthday? Who ... Labs , a digital infrastructure security company, launches the ... comes with usernames, passwords and PINs – 1U TM ...
(Date:12/10/2014)... 2014 CIE San Diego has launched an innovative trust ... enhances care coordination among social service and care providers by ... $1 million grant from the Alliance Healthcare Foundation to expand ... recognized as a "Live Well San Diego" partner on December ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 2Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 3Community Information Exchange San Diego Launches Pilot, Secures $1 Million Expansion Grant, and Becomes a "Live Well San Diego" Partner 4
... Botanic Gardens, Kew, The University of Western Australia, and the, ... increasing the frequency of fires may lead to ecosystem degradation ... this month in Trends in Plant Science they ... human lives and property are more at risk. However, ...
... [Brown University] Last July, President Obama adopted the recommendations ... policy to better manage the nation,s oceans, coastlines and the ... developing a plan to put the ideas into practice. Two ... social facets of marine management this month at the annual ...
... her search to understand one of the most basic human ... becoming one of the best studied model systems in neuroscience: ... professor of biomedical engineering and mechanical engineering in the McCormick ... the rat whisker system as a model to understand how ...
Cached Biology News:Experts question aspects of prescribed burning 2Brown scientists to discuss best practices for the oceans 2Brown scientists to discuss best practices for the oceans 3What a rat can tell us about touch 2What a rat can tell us about touch 3
(Date:1/22/2015)... (PRWEB) January 22, 2015 Diagenode, ... such as the Bioruptor® and complete solutions for ... for chromatin immunoprecipitation, alleviating the need for manual ... controls needed for ChIP of histones or transcription ...
(Date:1/22/2015)... SAN DIEGO , Jan. 22, 2015   ... company, and Sequenom, Inc. (NASDAQ: SQNM ... a development agreement for next generation noninvasive prenatal ... Cypher,s genome interpretation technology, called Mantis™, to advance ...
(Date:1/22/2015)... Mass. , Jan. 22, 2015   GenoSpace , a ... of tools to enable the broad use of genomic, imaging ... announced the appointment of Michelle Munson , CEO of ... director. Logo - http://photos.prnewswire.com/prnh/20150122/170713 ...
(Date:12/25/2014)... report “Service Quality Management and Telco Customer Experience Management ... Advancements, Worldwide Forecasts & Analysis (2014-2019)” defines and segments ... revenues. , Browse 152 market data tables, 19 ... “Service Quality Management (SQM) and Telco Customer Experience Management ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4GenoSpace Expands Board with Appointment of Michelle Munson 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4
... Biotherapeutics (OTC.BB: NWBO) (NW Bio) today announced that it will ... the Windsor Room of the Sir Francis Drake Hotel as ... emerging biotech companies held over 3 days this week in ... attendees are expected to be listening to presentations by up ...
... Md., Jan. 10, 2012 /PRNewswire-iReach/ -- ... pharmaceutical company focused exclusively in the HIV-1 therapeutic ... and the National Cancer Institute (NCI) to further ... maturation inhibitor drugs. Maturation inhibitors are a novel ...
... Riverside engineering professor and a team of researchers have ... could play a major role in keeping laptops and ... professor of electrical engineering at the UC Riverside Bourns ... Texas at Austin, The University of Texas at Dallas ...
Cached Biology Technology:NW Bio to Present Today at the OneMedForum SF 2012 Conference 2NW Bio to Present Today at the OneMedForum SF 2012 Conference 3DFH Pharma to Collaborate With National Cancer Institute to Develop Second-Generation HIV Maturation Inhibitor Drugs 2DFH Pharma to Collaborate With National Cancer Institute to Develop Second-Generation HIV Maturation Inhibitor Drugs 3Keeping electronics cool 2Keeping electronics cool 3
... against TATA Binding Proteins (TBP). Ascites Antibody ... and recognizes amino acids 41-57 and may ... of TBP occurs. This antibody does ... either as a nuclear extract or as ...
... sealer ideal for low to medium throughput applications. ... wide range of plates of differing heights when ... the sealer is pre-set for optimal sealing conditions ... in conjunction with ABgenes sealing foil or film ...
... CHEMICON Re-Blot Plus Western Blot Strong Antibody ... antibodies from Western blots that have been ... other isotopes. It is not recommended for ... as it is not possible to effectively ...
This unique buffer provides a gentle method for removal of primary and secondary antibodies to allow several reprobings on the same membrane. Gentle buffer will not alter the antigen for subsequent i...
Biology Products: