Navigation Links
Study explaining parasite gene expression could help fight toxoplasmosis and malaria
Date:1/2/2014

INDIANAPOLIS -- A newly identified protein and other proteins it interacts with could become effective targets for new drugs to control the parasite that cause toxoplasmosis, researchers led by investigators at Indiana University School of Medicine have reported.

The discovery could also open new research pathways for treatments for malaria.

The researchers determined that the protein, an enzyme called GCN5b, is necessary for the Toxoplasma parasite to replicate, so interfering with its activities could control the parasite. GCN5b is part of the molecular machinery that turns genes on and off in the parasite, working with other proteins that, the researchers discovered, are more plant-like than their counterparts in humans.

"GCN5b is a very different protein than its human counterpart, and proteins it interacts with are not found in humans," said William J. Sullivan Jr., Ph.D., associate professor of pharmacology and toxicology.

"That's what makes this exciting -- rather than just having one enzyme that we could go after, there could be a whole collection of associated enzyme components that could be potentially targeted for drug therapies to control this parasite," he said.

In discovering that some of the proteins interacting with GCN5b are plant-like transcription factors -- proteins that bind to DNA -- the researchers filled in what had been a missing link explaining how the parasites control the process of turning genes on and off, known as gene expression. The plant-like transcription factors recruit the GCN5b enzyme complex to activate a wide variety of genes for expression.

When the research team disabled the GCN5b complex, parasite replication swiftly came to a halt.

Dr. Sullivan and his colleagues reported their findings in the Jan. 2, 2014, online edition of the journal PLOS Pathogens.

An estimated 60 million people in the United States are infected with the toxo
'/>"/>

Contact: Eric Schoch
eschoch@iu.edu
317-274-8205
Indiana University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Montana State University research on algal biofuels keys larger study
2. Study finds patients give broad endorsement to stem cell research
3. Ill have what theyre having: Study finds social norms influence food choices
4. UTSW study identifies potential therapeutic target for incurable, rare type of soft-tissue cancer
5. International team completes systematic, genomic study of cervical cancer
6. Study finds axon regeneration after Schwann cell graft to injured spinal cord
7. Slippery bark protects trees from pine beetle attack, according to CU-Boulder study
8. Study offers clues to how plants evolved to cope with cold
9. Study shows Where Alzheimers starts and how it spreads
10. Study: Some plants may not adapt quickly to future climate change
11. Wayne State cholesterol study shows algal extracts may counter effects of high fat diets
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study explaining parasite gene expression could help fight toxoplasmosis and malaria
(Date:7/30/2014)... A deep-sea octopus protected and tended her eggs until ... published July 30, 2014 in the open-access journal ... Aquarium Research Institute and colleagues. , Octopuses typically have ... females protect and take care of their fertilized eggs ... eggs for 1 to 3 months, but little is ...
(Date:7/30/2014)... the University of Helsinki and the Universitat Autnoma de ... morphological changes which have taken millions of years to ... development of mice teeth, induced in the laboratory, scientists ... those observed in the fossil registry of rodent species ... , To modify the development of their teeth, the ...
(Date:7/30/2014)... associate professor Andrew S. Mount, performed cutting-edge research on ... novel anti-fouling paint for ships and boats and also ... team,s findings, published in Nature Communications ... attaches to a wide variety of surfaces using highly ... underwater heavy-duty adhesive. , "In previous research, we were ...
Breaking Biology News(10 mins):Deep-sea octopus has longest-known egg-brooding period 2Scientists reproduce evolutionary changes by manipulating embryonic development of mice 2Study: Marine pest provides advances in maritime anti-fouling and biomedicine 2
... professors are leading research teams that will work ... and the Caribbean to increase food production, improve ... change. The projects are part of the Sustainable ... Program (SANREM CRSP), a $15 million, five-year program ...
... study from Children,s Hospital Boston and the Boston-based Autism Consortium ... known as chromosomal microarray analysis, has about three times the ... (ASDs) than standard tests. Publishing in the April issue of ... that CMA become part of the first-line genetic work-up for ...
... WINSTON-SALEM, N.C. Vitamin D is quickly becoming the "go-to" ... to atherosclerosis. However, new evidence from a Wake Forest University ... those with low levels may have different effects based on ... do harm. The study is the first to ...
Cached Biology News:Researchers introducing sustainable agriculture practices to improve food security 2Researchers introducing sustainable agriculture practices to improve food security 3A better genetic test for autism 2A better genetic test for autism 3Vitamin D levels have different effects on atherosclerosis in blacks and whites 2Vitamin D levels have different effects on atherosclerosis in blacks and whites 3
(Date:7/30/2014)... 30, 2014   Wyle has been ... Lifecycle Mission Support Services (FILMSS) contract awarded by ... the terms of the contract, Wyle will provide ... Field, Calif. In particular, Wyle will provide program ... projects on the International Space Station and collaborative ...
(Date:7/30/2014)... BCC Research ( http://www.bccresearch.com ) reveals in its ... Applications , the global market for industrial enzymes is ... registering a five-year compound annual growth rate (CAGR) of ... the detergent enzyme segment with a CAGR of 11.3% ... almost every sector of industrial activity, ranging from technical ...
(Date:7/30/2014)... -- Orexigen Therapeutics, Inc. (Nasdaq: OREX ) today ... Outstanding Issues (LOI) from the European Medicines Agency,s Committee ... NB32 Marketing Authorization Application (MAA). NB32 (naltrexone sustained release ... being evaluated for weight loss. The key ... adequately addressed by the Company based in part on ...
(Date:7/30/2014)... 30, 2014   Epic Sciences, Inc. ("Epic"), ... diagnostics to personalize and advance the treatment and management ... T. Lucier as chairman of Epic,s board of ... Life Technologies (formerly Invitrogen). Mr. Lucier joins Epic,s board ... circulating rare cell analysis platform with special focus on ...
Breaking Biology Technology:Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 3Orexigen Receives CHMP Day 180 List of Outstanding Issues 2Orexigen Receives CHMP Day 180 List of Outstanding Issues 3Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3
... NORTH BILLERICA, Mass., Sept. 9 Seahorse Bioscience, Inc., the ... cellular bioenergetics, today announced it will present data with the ... Flux Analyzer in revealing the effects of KSR1 and nutrients ... The data will appear in two posters at the AACR ...
... , NEW YORK, Sept. 9 ... Vice President and General Manager of Informatics at Thermo Fisher ... HUNT Research Center and Biobank, about data integration: the benefits ... life sciences companies. , , ...
... , WATERTOWN, Mass., Sept. 9 EnVivo Pharmaceuticals ... vice president and chief financial officer. DiPalma is responsible ... and operations. , , "EnVivo has grown ... to help better manage our broad pipeline and increasing business ...
Cached Biology Technology:Seahorse Bioscience to Present Novel Cellular Bioenergetics Data in Collaboration with University of Nebraska at AACR Metabolism and Cancer Conference 2Don't Wait to Innovate: Future Pharmaceuticals Magazine Releases Its Issue on Innovation in IT, Cell-Based Therapy and Supply Chains 2EnVivo Pharmaceuticals Names Stephen DiPalma Chief Financial Officer 2
... is most widely used in combination ... differentially stain nucleic acids following polyacrylamide ... solution, Pyronin Y stains RNA red, ... Chem comp: Dye content ...
... The loxP-cm-loxP cassette is ... prokaryotic cells. The prokaryotic promoter ... resistance is a slightly modified version ... higher transcription efficiency than the generally ...
... Agencourt AMPure is a ... that requires no sample transfer, ... efficiently purifies small and large ... or 384-well microplates. Agencourt AMPure ...
... is a magnetic bead-based PCR ... sample transfer, centrifugation or filtration ... and large PCR extension products ... Agencourt AMPure can easily be ...
Biology Products: