Navigation Links
Study examines genetic defects linked to body abnormalities in patients with childhood cancer
Date:1/1/2008

Children with cancer have a higher prevalence of body abnormalities, such as asymmetric lower limbs and curvature of the spine, suggesting that the genetic defect responsible for the abnormality may play a role in the development of cancer, according to a study in the January 2 issue of JAMA.

Certain genetic syndromes can be associated with an increased risk for tumor and cancer development in children. Several studies have shown that developmental genes, which play a role in body plan formation during embryogenesis, are also involved in the development of cancer, according to background information in the article.

Johannes H. M. Merks, M.D., Ph.D., of Emma Childrens Hospital, Academic Medical Center, Amsterdam, the Netherlands, and colleagues conducted a study to assess the prevalence of morphological (body structure) abnormalities in a large group of childhood cancer patients. The study, conducted between January 2000 and March 2003, included 1,073 patients who underwent a physical examination for morphological abnormalities (such as differing length in limbs; broad hands or feet; prominent ears; curvature of the spine). The patient group consisted of 898 long-term survivors of childhood cancer and 175 newly diagnosed pediatric patients with cancer. The control group consisted of 1,007 schoolchildren examined in an identical way. The average ages of patients and controls were 21.2 and 10.4 years, respectively.

The researchers found that both major abnormalities and minor anomalies were significantly more prevalent in the pediatric cancer group (per 1,000 cases, patients had 268 major abnormalities and controls had 155 abnormalities). One or more major abnormalities were present in 26.8 percent of individual patients (15.5 percent in controls), two or more abnormalities in 5.1 percent of patients (1.6 percent in controls), and three or more abnormalities were found in 0.9 percent compared with none in controls.

One or mo
'/>"/>

Contact: Johannes H. M. Merks, M.D., Ph.D.
j.h.merks@amc.uva.nl
JAMA and Archives Journals
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... The meteorite impact that spelled doom for the dinosaurs ... flowering plants to a much greater extent than their ... researchers. The results are published in the journal ... a treasure trove of thousands of fossilized leaves of ... team was able to reconstruct the ecology of a ...
(Date:9/16/2014)... (KXL) would likely increase oil sands extraction, according to ... non-profit organization Near Zero. The results are detailed in ... both supporters and opponents of the pipeline. ... to significantly higher greenhouse gas emissions, with the exact ... "This report examines three main scenarios discussed by participants ...
(Date:9/16/2014)... 2014 Schizophrenia is associated with increased rates and ... research suggests that the relationship between schizophrenia and smoking ... use nicotine to self-medicate symptoms and cognitive impairment associated ... the current issue of Biological Psychiatry , sheds ... level of nicotine receptors in the brain was lower ...
Breaking Biology News(10 mins):Meteorite that doomed dinosaurs remade forests 2Meteorite that doomed dinosaurs remade forests 3Meteorite that doomed dinosaurs remade forests 4Keystone XL would likely raise oil sands production and greenhouse gas emissions 2Smoking and schizophrenia linked by alterations in brain nicotine signals 2
... University of Exeter biologist has discovered a ,lost, species of bat ... long-eared bat is the first of its species to be found ... by Dr Fiona Mathews, Senior Lecturer at the University of Exeter, ... The Scilly Isles Bat Group called in Dr Mathews and ...
... University of Adelaide computer scientists are developing image-based ... of improved cereal varieties for the harsher environmental conditions ... van den Hengel, Director of the Australian Centre for ... plant physiologists and an industry partner to develop technology ...
... bacteria that cause Lyme disease, one of the most ... hide out in the lymph nodes, triggering a significant ... to rout the infection, report researchers at the University ... involving mice may explain why some people experience repeated ...
Cached Biology News:'Lost' bats found breeding on Scilly 2Imaging cereals for increased crop yields 2Lyme disease bacteria take cover in lymph nodes 2
(Date:9/17/2014)... (PRWEB) September 17, 2014 NASA’s MESSENGER ... Valcor Engineering Corporation is proud to have one of ... The MESSENGER mission is a scientific investigation of the ... to be sent there, and has provided a vast ... Valcor’s V27200 family of latch valves utilize solenoids that ...
(Date:9/17/2014)... The Alliance for Clinical Research ... collaborative building a global system to enhance safety, ... Phase 3 of its Site Accreditation and Standards ... Kalali, Vice-President, Global Head, Neuroscience Center of Excellence ... Quality Integration (CQI) Consulting will lead the effort ...
(Date:9/16/2014)... , Sept. 16, 2014 This report analyzes the ... Product Segments: Software, Hardware, and Biocontent. The report provides separate ... Japan , Europe , ... , and Rest of World. Annual estimates and forecasts are ... historic analysis is provided for these markets. Market data and ...
(Date:9/16/2014)... 2014  Biocom, the association representing the ... 9 th Annual National Health Information Technology Week, ... in improving our health care system. ... the world,s most vibrant hubs for health IT and ... to genomic testing to remote patient monitoring," said ...
Breaking Biology Technology:Global Standards Initiative for Clinical Research Sites Advances 2Global Standards Initiative for Clinical Research Sites Advances 3Global Standards Initiative for Clinical Research Sites Advances 4Global Bioinformatics Industry 2Global Bioinformatics Industry 3Global Bioinformatics Industry 4Global Bioinformatics Industry 5Global Bioinformatics Industry 6Global Bioinformatics Industry 7Global Bioinformatics Industry 8Global Bioinformatics Industry 9Global Bioinformatics Industry 10Global Bioinformatics Industry 11Global Bioinformatics Industry 12Global Bioinformatics Industry 13Global Bioinformatics Industry 14Global Bioinformatics Industry 15Global Bioinformatics Industry 16Global Bioinformatics Industry 17Global Bioinformatics Industry 18Global Bioinformatics Industry 19Global Bioinformatics Industry 20Global Bioinformatics Industry 21Global Bioinformatics Industry 22Global Bioinformatics Industry 23Biocom Recognizes National Health IT Week 2
... Claire, Wis. -- Two very different types of technologies ... as the Eau Claire Area Economic Development Corp. ... Own Business" contest was started in 1986 and given awards ... and access to low-interest loans. Since 1986, the EDC has ...
... I was reminded by an article in the Chicago Tribune ... on Oct. 9, 1940, he would have been 65 years old if ... Dec. 8, 1980. He was 40 years old. The article gave a ... sure this statement is going to provoke some comment but Im letting ...
... Wisconsin's energy future may include more biobased fuels to ... rural economies. A recent policy initiative, consortium and related ... and try to incorporate major industrial sectors into the ... the consortium] is to find out where in that ...
Cached Biology Technology:StrandVision, Arctic Cool win Eau Claire business contest awards 2Midwest biotech stocks drop like a rock during the third quarter 2Midwest biotech stocks drop like a rock during the third quarter 3Biofuels surge forward 2Biofuels surge forward 3Biofuels surge forward 4
LTBP-2 (7B10)...
... Product Rabbit polyclonal to ... conjugated to KLH, corresponding to amino ... / Specificity Cross-reacts with Rat.Expected to ... Mouse (100% identity with immunogen), Rabbit (100% ...
Mouse Anti-Gemin2...
RayBio Human Angiogenesis Antibody Array 2.1 (8 array membranes) with Accessory, detects 23 angiogenic factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Biology Products: