Navigation Links
Study discovers genetic pathway impacting the spread of cancer cells
Date:5/3/2012

LONDON, ON - In a new study from Lawson Health Research Institute, Dr. Joseph Torchia has identified a new genetic pathway influencing the spread of cancer cells. The discovery of this mechanism could lead to new avenues for treatment.

Regular cell division is regulated by methylation, a series of chemical changes. Methylation modifies DNA to ensure cells divide at a healthy, balanced rate. In cancer, the methylation process is unbalanced, causing cells to resist regulation and divide uncontrollably.

Research suggests changes in genetics play a role in this process, yet little is known about the mechanism. In a new study led by Dr. Torchia and his colleagues, a hormone called Transforming Growth Factor Beta (TGF-β) is starting to show the answers. Using genetic sequencing, they analyzed the effects of TGF-β on DNA methylation to reveal a never-before-seen pathway.

When TGF-β comes into contact with a cell it activates the tumor-suppressing gene, which stops the cells from dividing. According to Dr. Torchia's group, ZNF217, a cancer-causing gene, can interfere with this process by binding to the DNA. This prevents the tumour-suppressing genes from activating, and the cells continue to divide.

These results characterize the dynamic processes underlying cell division, suggesting genetic influencers must be balanced to keep cell division under control. Most importantly, they provide hope for new cancer therapies.

"This link between methylation and TGF-β has never been shown before," Dr. Torchia says. "If we understand how methylation is regulated, and identify the machinery that's involved, we may be able to target some of the machinery therapeutically and turn these genes back on to fight the cancer."

The full study is published in Molecular Cell, available here: http://www.cell.com/molecular-cell/home.


'/>"/>

Contact: Sonya Gilpin
sonya.gilpin@lawsonresearch.com
519-685-8500 x75852
Lawson Health Research Institute
Source:Eurekalert  

Page: 1

Related biology news :

1. TGen leads new National Institutes of Health study of brain tumors
2. First-of-its-kind study reveals surprising ecological effects of earthquake and tsunami
3. Syracuse University study finds autumn advantage for invasive plants in eastern United States
4. Modern hybrid corn makes better use of nitrogen, study shows
5. Pacific islands may become refuge for corals in a warming climate, study finds
6. Heart study suggests city center pollution doubles risk of calcium build-up in arteries
7. Kinesiology team gets $975,000 Defense grant to study effects of heavy loads on soldiers
8. New study finds a protein combination is best to consume post-workout for building muscle
9. Study finds Western diet detrimental to fetal hippocampal tissue transplants
10. Women & Infants participating in study of treatment of common viral infection in pregnancy
11. Study finds soda consumption increases overall stroke risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study discovers genetic pathway impacting the spread of cancer cells
(Date:11/6/2014)... an asset for a predator. Except when that predator runs ... beetle, relative to its size, is the fastest creature on ... lengths per second (at about five miles per hour). The ... the sprinting gold from the tiger beetle, a person would ... tiger beetle has a problem. At peak speeds, everything becomes ...
(Date:11/5/2014)... of biology in the UTSA College of Sciences, ... selected to receive a two-year $300,00 National Science ... (EAGER). The funding supports President Obama,s BRAIN Initiative, ... new technology that will demystify complex brain processes. ... neuroscience are broken into the interactions of multiple ...
(Date:11/5/2014)... in their ability to identify scents and odors. ... perceptual evaluation of odors, with women outperforming men on ... differences in olfactory detection may play a role in ... perception of smell, which is naturally linked to associated ... suggested to be cognitive or emotional, rather than perceptual. ...
Breaking Biology News(10 mins):The tiger beetle: Too fast to see 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3The female nose always knows: Do women have more olfactory neurons? 2
... German researchers have identified four biomarkers that correctly ... the accurate prediction of patient outcomes. Their results are ... of Molecular Diagnostics . Current prognosticators of bladder ... of foci, have limited usefulness for clinicians since they ...
... a new study in the Journal of Animal Science ... immune system of adult horses. According to the researchers, the ... evaluated in other species but not extensively in horses. ... Kentucky, said the amount of selenium in soil and forages ...
... common clinical inhibitor and the HIV-1 protease enzyme has ... from the US, Britain and France using neutrons at ... science with the first true picture of how an ... and critically how its performance could be improved. The ...
Cached Biology News:MicroRNAs have diagnostic and prognostic potential in urinary bladder cancer 2Researchers study selenium's effects on horses 2Neutron studies of HIV inhibitors reveal new areas for improvement 2Neutron studies of HIV inhibitors reveal new areas for improvement 3Neutron studies of HIV inhibitors reveal new areas for improvement 4
(Date:11/21/2014)... CA (PRWEB) November 21, 2014 Why ... that makes Albert Einstein so instantly recognizable? Why have ... physicist, mathematician, astronomer and author Hilton Ratcliffe seeks out ... have nothing at all to do with science. In ... Harbor Publishing , November 21, 2014), Ratcliffe puts it ...
(Date:11/21/2014)... , Nov. 20, 2014 /CNW/ - Aequus ... to announce that it has closed a brokered ... warrants for approximately C$3.7 million.  Cormark Securities Inc. ... in the Brokered Offering for a syndicate of ... PI Financial Corp. (collectively the "Agents"). Concurrently with ...
(Date:11/18/2014)... FL (PRWEB) November 17, 2014 ... point-of-care diagnostic tests – today announces its third ... and Prevention’s (CDC) Get Smart About Antibiotics Week ... Week is a national campaign designed to highlight ... health departments, and non-profit and for-profit partners to ...
(Date:11/18/2014)... 18, 2014 Alanda Software, a ... Reporting solutions, announced today that a top tier ... Consummate Provider™ solution in both the U.S. and ... SaaS based, Data Quality remediation portal, designed to ... party Providers improve their ability to capture, transmit ...
Breaking Biology Technology:“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3Alanda Software Completes Successful Implementation of Global Data Quality & Vendor Management Solution for Top Tier Global Biopharmaceutical Company 2
... was a baby. They know what it looks like today. ... youth. Thanks to technological advances, however, scientists hope to complete ... cosmos developed into the kind of place that could support ... gather these never-before-obtained insights with a potentially "game-changing" instrument that ...
... 30, 2011 PracticeMatch, based in St. Louis, Mo., ... new service to connect physicians with potential employers. These ... of training to speak face-to-face with representatives from some ... Thompson, program relations specialist for PracticeMatch, says the goal ...
... Parkinson Foundation (NPF) has awarded more than $1 million ... investigators awards program, NPF is supporting work to advance three ... study, 2) a clinical trial to treat memory impairment, and ... sleep apnea in PD. "Each of these projects ...
Cached Biology Technology:Scientists hope to get glimpse of adolescent universe from revolutionary instrument-on-a-chip 2Scientists hope to get glimpse of adolescent universe from revolutionary instrument-on-a-chip 3Scientists hope to get glimpse of adolescent universe from revolutionary instrument-on-a-chip 4PracticeMatch Now Offers Free Physician Career Fairs 2National Parkinson Foundation Awards More Than $1 Million for Research 2National Parkinson Foundation Awards More Than $1 Million for Research 3
Human IL-29/IFN-lambda 1 Biotinylated Affinity Purified PAb...
Anti-Potassium Channel EAG-1 Immunogen: Synthetic peptide from the C-terminus of rat Kv10.1 (Accession Q63472). The immunogen sequence is identical in mouse and 14/16 residues identical in human...
WIF-1 (N-20)...
VEGF Receptor-2, phospho-specific (Tyr996)...
Biology Products: