Navigation Links
Study details paired risk factors in preeclampsia
Date:9/10/2013

ior studies that have suggested a higher risk of preeclampsia from a high degree of similarity among HLA genes in the mother and father, and, independently, higher levels of pre-pregnancy semen exposure.

But this study, Triche and co-authors at the University of Iowa wrote, "provides to our knowledge the first examination of the effects of maternal-fetal HLA sharing in the context of history of exposure to seminal fluid."

(Co-author Audrey Saftlas led another study, online Aug. 22 in the journal, showing that increasing degrees of vaginal, but not oral, semen exposure significantly reduced preeclampsia risk among women in the SOPHIA population.)

Different means compatible?

The underlying biology, Triche said, appears to relate to how the mother's immune system comes to view these foreign genes, first as introduced by the father's sperm and then in the fetus.

"At the maternal-fetal interface it appears that for a successful pregnancy to occur it's likely the mother has to recognize it as foreign and develop a tolerance," Triche said.

In other words, unlike a transplanted organ that is most readily accepted if HLA genes are very similar, a fetus will be welcome if it appears genetically distinct. Greater exposure to the father's semen perhaps better primes the mother's immune system to recognize and tolerate that difference.

That said, the study yielded a nuanced secondary finding, which is that similarity between mother and fetus for the Class II gene HLA-DQB1 was associated with a smaller but still significant increase in preeclampsia odds among women who had higher degrees of exposure to semen.

"That is something that has to be looked at in further studies," Triche said. It could be, she said, that those results simply confirm a unique role in preeclampsia for sharing of that particular gene.

Potential for planning

If the higher odds from these particular combina
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. African-American study identifies 4 genetic variants associated with blood pressure
2. Therapy slows onset and progression of Lou Gehrigs disease, study finds
3. Cytos Biotechnology Presents Additional Results From Phase 2a Study of CYT003 for the Treatment of Allergic Asthma
4. LSUHSC researchers develop new system to better study behavior, cell function
5. 400-year study finds Northeast forests resilient, changing
6. UCSF receives $4.5M to study value of gene sequencing in newborns
7. First study to investigate the human genome in multiple sclerosis
8. Red cedar tree study shows that Clean Air Act is reducing pollution, improving forests
9. Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression
10. Type 2 diabetes study to examine role amylin plays in disease
11. Cell study offers more diabetic patients chance of transplant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ... Iris Recognition Market 2015-2019" report to their offering. ... market to grow at a CAGR of 23.5 percent ... the present scenario and the growth prospects of the ... calculate the market size, the report considers the revenue ...
(Date:3/24/2015)... BEACH GARDENS, Fla. , March 24, 2015 ... biometric identity management solutions, today announced that its ... premium clothing accessory retailer Goorin Bros . ... The Crossmatch biometrics-based solution secures access to the ... from the increased risk of data breaches. ...
(Date:3/23/2015)... LOS ANGELES , March 23, 2015  In ... in Federal fraud case conviction losses. This figure accounts ... fraud, which, according to The Nilson Report, exceeds $11 ... an investigative tool after a crime has occurred. Investor ... Agent and polygraph expert Joe Paolella partnered ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... Assistant Professor Frank J. Slack at Yale University has identified ... lung cancer, presenting new possibilities for diagnosis and treatment. The ... and Developmental Cell. , The oncogene Ras is out of ... over-expressed or activated by mutation. According to Slack, a member ...
... at the Marine Biological,Laboratory (MBL) has published ... that supports her hypothesis that, when combined, ... as BCE--can act synergistically to alter a ... have previously studied the effects,of these pollutants ...
... a longtime University of Chicago collaborator, Goldstein conducted an experiment ... these skinny, graceful fish can swim from salt water to ... prompt an equally drastic physiological change: Our cells would take ... and rapidly causing death. So how do skates do it? ...
Cached Biology News:Yale Scientists Find MicroRNA Regulates Ras Cancer Gene 2Clam embryo study shows pollutant mixture adversely affects nerve cell development 2Clam embryo study shows pollutant mixture adversely affects nerve cell development 3Sea skate experiment sheds light on human cell transport 2
(Date:4/21/2015)... 2015  This research service analyzes the various PEVC ... biotechnology industry. The deals are analyzed based on their ... on the geographic region and buyer types. The study ... into account various deal multiples such as enterprise value, ... company. Executive Summary Key ...
(Date:4/21/2015)... April 21, 2015 The North American chromatography systems ... from 2014 to 2019. Based on geography, this market has ... and Mexico . The U.S. accounted for ... . The major factors driving the growth of chromatography systems ... industries are the prime users of chromatography techniques. ...
(Date:4/21/2015)... and Markets ( http://www.researchandmarkets.com/research/z24n33/global ) has announced ... 2019" report to their offering. The ... 3.7 Billion in 2013 with the anticipation of its ... The report is an outcome of an ... opportunities listed in the section of the bioinformatics trends. ...
(Date:4/21/2015)... 2015 Research and Markets ( ... "Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) ... Stem cell research and experimentation have been ... stem cells have the unique ability to divide ... allows them to differentiate into a wide variety ...
Breaking Biology Technology:Funding Patterns in the Global Pharma and Biotech Industry 2North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 2North American Chromatography systems Market by Types, & by End-Users - Forecast to 2019 3Global Bioinformatics Market Outlook Report 2014-2019 - The US$ 3.7 Billion Market is Expected to Grow at a CAGR of 19% during 2015-2019 2Global Bioinformatics Market Outlook Report 2014-2019 - The US$ 3.7 Billion Market is Expected to Grow at a CAGR of 19% during 2015-2019 3Global Complete 2015-16 Induced Pluripotent Stem Cell (iPSC) Industry Report 2
... power they use. The more power they use, the hotter ... overheat. It doesn,t take a rocket scientist to understand what ... of electronics, thermal control is always one of the limiting ... to help cool down electronic components. However, Jeffrey ...
... BioStorage Technologies, the premier global provider of ... has opened its new state-of-the-art biorepository facility in ... company,s strategic growth plan, and represents a 4.6MM ... near the second largest FedEx hub in the ...
... 2011 Reportlinker.com announces that a new ... catalogue: Future Directions in ... Big Pharma has begun ... Pfizer and Novartis in 2009, and Cephalon ...
Cached Biology Technology:NASA is making hot, way cool 2NASA is making hot, way cool 3BioStorage Technologies Expands U.S. Operations with Opening of New Biorepository Facility 2BioStorage Technologies Expands U.S. Operations with Opening of New Biorepository Facility 3Reportlinker Adds Future Directions in Regenerative Medicine 2Reportlinker Adds Future Directions in Regenerative Medicine 3Reportlinker Adds Future Directions in Regenerative Medicine 4Reportlinker Adds Future Directions in Regenerative Medicine 5Reportlinker Adds Future Directions in Regenerative Medicine 6
PURA Immunogen: PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rabbit polyclonal to CAMK 1D beta ( Abpromise for all tested applications). entrezGeneID: 57118 SwissProtID: Q5SQQ7...
Acetyl-Histone H2B (Lys20) Antibody...
...
Biology Products: