Navigation Links
Study demonstrates cells can acquire new functions through transcriptional regulatory network
Date:3/14/2012

Researchers at the RIKEN Omics Science Center (OSC) have successfully developed and demonstrated a new experimental technique for producing cells with specific functions through the artificial reconstruction of transcriptional regulatory networks. As an alternative to induced pluripotent stem cells, the technique promises to enable faster and more efficient production of functional cells for use in cancer therapy and a variety of other areas.

Starting with the first-ever production of induced pluripotent stem cells (iPS cells) in 2006, cell reprogramming - the genetic conversion of cells from one type to another - has revolutionized stem cell research and opened the door to countless new medical applications. Inducing such reprogramming, however, is difficult, inefficient and time-consuming, involving a largely hit-or-miss process of selecting candidate genes.

In the current study, the OSC research team explored an alternative to iPS cells based on the use of transcriptional regulatory networks (TRNs), networks of transcription factors and the genes they regulate. Previous research by the team characterized the dynamic regulatory activities of such transcription factors during cellular differentiation from immature cell (monoblast) to developed (monocyte-like) cell using human acute monocytic leukemia cell lines (THP-1). Their findings led them to hypothesize that functional characteristics of the cell-type are maintained by its specific TRN.

Their new paper builds on this hypothesis, establishing a series of new methods for identifying transcription factors (TFs) for the monocyte network, which play a key role in inducing cell-specific functions. Four core TF genes of the monocyte TRN, identified using this approach, were introduced into human fibroblast cells, expression of which activated monocytic functions including phagocytosis, inflammatory response and chemotaxis. Genome-wide gene expression analysis of this reprogrammed cell
'/>"/>

Contact: RIKEN Global Relations Office
gro-pr@riken.jp
81-484-621-225
RIKEN
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
3. Crystal structure of archael chromatin clarified in new study
4. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
5. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
6. BYU study: Using a gun in bear encounters doesnt make you safer
7. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
8. New study will help protect vulnerable birds from impacts of climate change
9. Law that regulates shark fishery is too liberal: UBC study
10. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
11. Leatherback turtle migration study identifies Pacific danger zones for endangered species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/19/2015)... Conn. , March 19, 2015  NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market, announces ... in a news clip that aired this week on ... ) . In a segment "The Next Great ... wallet ,a new way to pay, and ,a really big ...
(Date:3/17/2015)... 17, 2015 MedNet Solutions , ... clinical study management systems, is pleased to announce ... ARENA,s Outsourcing in Clinical Trials Southeast conference – ... an excellent forum for MedNet to showcase ... software-as-a-service (SaaS) eClinical technology platform. We ...
(Date:3/17/2015)... 2015  MecklerMedia Corporation (OTCQX: MECK) announced its ... robots ever held in New York ... 11-13, 2015 at the Javits Convention Center. ... include: Acorn Product Development; Axis NJ; c-Link Systems; ... Littler; NewBotic Corporation; Neya Systems LLC; Reliabotics; RoboKind; ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3Connect With MedNet Solutions At Outsourcing In Clinical Trials Southeast 2MecklerMedia's RoboUniverse New York Announces Sponsors and Exhibitors, May 11-13, 2015 2
... notorious for their thick skin and well-armored bodies. So it comes ... touch is one of the most acute in the animal kingdom. ... of small, pigmented domes that dot their skin all over their ... jaws. A new study, published in the Nov. 8 issue ...
... 7, 2012 Listed below are the selected highlights for ... journal, GENETICS . The November issue is available ... , Vol. 192, November 2012, Copyright 2012. Please ... in these articles. ISSUE HIGHLIGHTS , An ...
... Every week in his clinic at the University of Michigan, ... dying or shrinking due to disease or injury. ... other effects that nerve-destroying conditions cause and wishes he ... regenerate their nerves. Then he heads to his research lab ...
Cached Biology News:Despite their thick skins, alligators and crocodiles are surprisingly touchy 2Despite their thick skins, alligators and crocodiles are surprisingly touchy 3Genetics Society of America's GENETICS journal highlights for November 2012 2Genetics Society of America's GENETICS journal highlights for November 2012 3Genetics Society of America's GENETICS journal highlights for November 2012 4Stem cells + nanofibers = Promising nerve research 2Stem cells + nanofibers = Promising nerve research 3
(Date:3/25/2015)... March 25, 2015 Optimal Research, LLC has ... Excellence (ViE) Award "Best Clinical Site or Trial Network". ... Optimal has been selected as a nominee in this ... a "Highly Recommended" distinction in 2014. The ViE awards ... efforts, accomplishments, and positive contributions of companies and individuals ...
(Date:3/25/2015)... , March 25, 2015  S&P Capital ... Factual Stock Report coverage on Abattis Bioceuticals ... ATTBF; CSE: ATT): is a specialty biotechnology company ... cultivating, licensing and marketing proprietary ingredients, bio-similar compounds, ... in North America . The ...
(Date:3/25/2015)... Md. , March 25, 2015 Accelovance, ... named a finalist for "Best Contract Research Organization" at ... the World Vaccine Congress. This is ... a finalist for the award, winning for "Best Contract ... a "Highly Recommended" distinction in 2013. "We,re ...
(Date:3/25/2015)... UK (PRWEB) March 25, 2015 An ... natural ingredients in all forms of food nutrients, regulatory ... to a substantial rise in demand for natural astaxanthin ... have started to ramp up their capacities to satisfy ... both natural and synthetic source astaxanthin (used in nutraceuticals, ...
Breaking Biology Technology:Optimal Research Nominated 2015 Vaccine Industry Excellence (ViE) Award 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on Abattis Bioceuticals Corp. in S&P Capital IQ Factual Stock Reports 5Accelovance Nominated for 2015 Vaccine Industry Excellence (ViE) Awards 2Global Astaxanthin Market to Reach Value of USD 1.1 billion by 2020, Expects Industry Experts in New Report Available at MarketPublishers.com 2
... Inc. , a software developer for off-road mapping applications, closed ... deal with Kegonsa Capital Partners that values the ... in funds that will enable it to furhter develop its ... vehicles - maps that are designed to interface with global ...
... looking for health information technology to have a moderating ... while longer, according to the head of an influential ... CEO of the Healthcare Information and Management Systems ... improving interoperability between facilities remain high IT priorities, but ...
... a trade owner have to purchase all relevant domain names ... does not register all the variations, are they free for ... defunct businesses? , ,These are questions posed by a ... on its own facts, the following principles can be used ...
Cached Biology Technology:Wausau start up secures $560K for GPS maps 2Wausau start up secures $560K for GPS maps 3CEO of healthcare group still hopeful IT will save employers money 2CEO of healthcare group still hopeful IT will save employers money 3Is your business domain at risk? 2Is your business domain at risk? 3Is your business domain at risk? 4
Anti-CoralHue Dronpa Green Monoclonal Antibody Research Focus: cell surface antigens Storage: -20C Shipping Temperature: +4C...
Phospho-FKHR (Thr24)/FKHRL1 (Thr32) Antibody...
Prostaglandin-E2 receptor EP2/EP3 Market Segment: GPCRs...
... - Red, 20X Immunogen ... at 20X concentration for use in ... Quality Assurance ... fluorescence polarization assays. ...
Biology Products: