Navigation Links
Study demonstrates cells can acquire new functions through transcriptional regulatory network
Date:3/14/2012

Researchers at the RIKEN Omics Science Center (OSC) have successfully developed and demonstrated a new experimental technique for producing cells with specific functions through the artificial reconstruction of transcriptional regulatory networks. As an alternative to induced pluripotent stem cells, the technique promises to enable faster and more efficient production of functional cells for use in cancer therapy and a variety of other areas.

Starting with the first-ever production of induced pluripotent stem cells (iPS cells) in 2006, cell reprogramming - the genetic conversion of cells from one type to another - has revolutionized stem cell research and opened the door to countless new medical applications. Inducing such reprogramming, however, is difficult, inefficient and time-consuming, involving a largely hit-or-miss process of selecting candidate genes.

In the current study, the OSC research team explored an alternative to iPS cells based on the use of transcriptional regulatory networks (TRNs), networks of transcription factors and the genes they regulate. Previous research by the team characterized the dynamic regulatory activities of such transcription factors during cellular differentiation from immature cell (monoblast) to developed (monocyte-like) cell using human acute monocytic leukemia cell lines (THP-1). Their findings led them to hypothesize that functional characteristics of the cell-type are maintained by its specific TRN.

Their new paper builds on this hypothesis, establishing a series of new methods for identifying transcription factors (TFs) for the monocyte network, which play a key role in inducing cell-specific functions. Four core TF genes of the monocyte TRN, identified using this approach, were introduced into human fibroblast cells, expression of which activated monocytic functions including phagocytosis, inflammatory response and chemotaxis. Genome-wide gene expression analysis of this reprogrammed cell
'/>"/>

Contact: RIKEN Global Relations Office
gro-pr@riken.jp
81-484-621-225
RIKEN
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
3. Crystal structure of archael chromatin clarified in new study
4. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
5. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
6. BYU study: Using a gun in bear encounters doesnt make you safer
7. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
8. New study will help protect vulnerable birds from impacts of climate change
9. Law that regulates shark fishery is too liberal: UBC study
10. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
11. Leatherback turtle migration study identifies Pacific danger zones for endangered species
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... the International Journal of Cancer earlier this ... based on findings showing successful reduction in the risk ... of cells in the cervix. , The findings ... cells, or SCJ cells. These cells reside in the ... of cervical cancer. A research team co-led by Christopher ...
(Date:7/25/2014)... Birla, associate professor of biomedical engineering at the ... on tissue engineering and artificial organ development., "Introduction ... comprehensive guide to entering into the field of ... professor of biomedical engineering at UH, served as ... that while there are other published books on ...
(Date:7/25/2014)... has opened the way for the development of new lines ... annual barley production is second only to wheat with 7-8 ... most important diseases of barley. , Senior Research Scientist Dr ... growths on the cell walls of barley plants that block ... research, by the ARC Centre of Excellence in Plant Cell ...
Breaking Biology News(10 mins):Clearing cells to prevent cervical cancer 2University of Houston researcher publishes textbook on tissue engineering 2New hope for powdery mildew resistant barley 2
... The ancient reserves of methane gas seeping from the melting ... they already knew: As the permafrost thaws, there is a ... warming. The trick was figuring out how much, said ... State University. The four-member team whose findings were ...
... over seven billion and all of these people need feeding. ... on numbers but on its average mass. New research published ... has estimated the total mass of the human population, ... biomass due to the overweight and obesity. Up to ...
... led by Professor Tadashi ISA, Project Assistant Professor ... Sciences, The National Institutes of Natural Sciences and ... double viral vector transfection technique" which can deliver ... two new kinds of gene transfer vectors. With ...
Cached Biology News:Study: Seeking Arctic methane has serious implications for Florida coastline 2The weight of nations: An estimation of adult human biomass 2Manipulation of a specific neural circuit buried in complicated brain networks in primates 2
(Date:7/25/2014)... Pa. , July 25, 2014 /PRNewswire-iReach/ -- ... and consulting for global corporations operating in highly ... host its first annual Global User Group Conference, ... historic Philadelphia, Pennsylvania at ... - http://photos.prnewswire.com/prnh/20140724/130263 This ...
(Date:7/24/2014)... New York, NY - July 24, 2014 -- Keryx ... results from the long-term, randomized, active control Phase 3 ... ferric iron-based phosphate binder, for the treatment of hyperphosphatemia ... The PERFECTED study (PhosphatE binding and iRon delivery with ... the Journal of the American Society of Nephrology ...
(Date:7/24/2014)... Calif. , July 24, 2014  Now available ... to home. Rehealth Regenerative Therapies , located in ... and other physically active people a new health option: ... Regardless of age, countless patients suffer from joint ... activities, such as muscle tears, torn rotator cuff, tennis ...
(Date:7/24/2014)... Security forces worldwide rely on sophisticated equipment, trained ... other public areas against terrorist attacks. A revolutionary ... about to make their job much easier. , ... Patolsky of Tel Aviv University ,s School of ... developed by the Herzliya company Tracense, picks up ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2
... MONTREAL and KIEL, Germany, September ... at the Kiel- based Collagen,Research Institute (CRI) have ... (FORTIGEL(R)) in the context of cell experiments.,Last weekend ... congress of the,Osteoarthritis Research Society International (OARSI) in ...
... NATICK, Mass., Sept. 14 Boston Scientific ... it has entered into a co-marketing agreement with Bladder ... solutions for urinary incontinence. Bladder Health Network offers ... and results analysis, helping to ensure that physicians and ...
... Italy, September 14 Health Robotics today reported,that Dr M ... across all of its I.V. Compounding Centers in Malaysia,Singapore, Indonesia, ... due diligence on 2 companies in the field of I.V.,Robotics, ... to RIVA,s,publicly announced multi-year delays in bringing their robot to ...
Cached Biology Technology:Important Step Forward in Osteoarthritis Research: Bioactive Collagen Peptides Stimulate the Regeneration of Cartilage Tissue 2Important Step Forward in Osteoarthritis Research: Bioactive Collagen Peptides Stimulate the Regeneration of Cartilage Tissue 3Boston Scientific's Urology/Gynecology Business Forms Marketing Alliance with Bladder Health Network 2Boston Scientific's Urology/Gynecology Business Forms Marketing Alliance with Bladder Health Network 3Dr M Group Selects Health Robotics' Technology Over RIVA for all of its I.V. Compounding Centers in South East Asia 2Dr M Group Selects Health Robotics' Technology Over RIVA for all of its I.V. Compounding Centers in South East Asia 3Dr M Group Selects Health Robotics' Technology Over RIVA for all of its I.V. Compounding Centers in South East Asia 4
Preparation Note: Prepared by method of Wimmer, E., et al., Biochemistry, 7, 2623 (1968). Quality Clarifier: Acceptor Activity: approx. 1000 picomoles phenylalanine per A 260 unit (not determined b...
... which is based on a new flow-through technology, ... in situ hybridization of tissues on microscope slide ... study of gene expression, in situ hybridization (ISH) ... can be used to validate and confirm results ...
... Array Analyst Software has been optimized for ... algorithms allow the software to quickly and ... each well of an ELISA plate or ... Analyst Software has been customized to incorporate ...
... products feature a dual strength adhesive system which ... use. The adhesives on either side of the ... adheres to the glass has an easy release ... coverslip, forms a stronger bond. This means that ...
Biology Products: