Navigation Links
Study confirms how the body regulates high levels of CO2 in the blood
Date:6/11/2014

In a recently published study in the journal Experimental Physiology, Brazilian researchers have confirmed the importance of a specific group of neurons found in a region of the brain known as the retrotrapezoid nucleus (RTN) in detecting changes in carbon dioxide (CO2) levels and in modulating the activity of the neuronal groups that control respiratory activity.

Scientists from the Biomedical Sciences Institute of the University of So Paulo (USP) and the School of Dentistry at the So Paulo State University (Unesp) participated in the study.

"CO2 is important for regulating the acid-base balance of the blood. When the concentration of this gas becomes higher than normal, the blood tends to become more acidic, which promotes the activation of specialized sensors called chemoreceptors," said Eduardo Colombari, professor at the School of Dentistry at Unesp.

"Some of these chemoreceptors are located in the central nervous system; more precisely, on the ventrolateral surface of the medulla oblongata [the region of the brain responsible for neurovegetative control that forms the interface between the spinal cord and the mesencephalon] in the RTN," he explained.

According to Colombari, the neurons in this region express a specific marker that allows them to be identified. This marker consists of a transcription factor called Phox2b, which is involved in the cell differentiation of autonomic and respiratory neurons, that communicate with other neural groups responsible for controlling respiratory activity in order to keep CO2 levels within the physiological range.

Previous studies in the scientific literature, said Colombari, have suggested that various neuronal groups, such as the nucleus of the solitary tract, the raphe nuclei (which secrete serotonin), and the pontine and hypothalamic areas, were involved in the control of chemoreception (in this case, the detection and modulation of CO2 levels).

The group's work has demonstrated, however, that the respiratory changes caused by the increase in CO2 levels are compromised during the occurrence of selective destruction of the RTN neurons that express Phox2b.

The researcher further explained that the work illustrated how a small region of the brain contains neurons with a classic biochemical signature (Phox2b) which are involved in detecting and maintaining adequate levels of CO2, thus allowing the maintenance of homeostasis.

According to Colombari, advances in understanding the mechanisms involved in the perception of CO2 levels in the central nervous system could help prevent cases of sudden death in infants and adults in the future.


'/>"/>

Contact: Samuel Antenor
samuel@fapesp.br
55-113-838-4381
Fundao de Amparo Pesquisa do Estado de So Paulo
Source:Eurekalert

Related biology news :

1. Gum disease bacteria selectively disarm immune system, Penn study finds
2. CU Denver study finds serious challenges to New Urbanist communities
3. New study shows that oatmeal can help you feel full longer
4. New study finds text messaging program benefits pregnant women
5. Penn receives $10 million award to study asbestos adverse health effects, remediation
6. Study reveals rats show regret, a cognitive behavior once thought to be uniquely human
7. Breakthrough study solves plant sex mystery
8. Saving trees in tropics could cut emissions by one-fifth, study shows
9. Can mice mimic human breast cancer? MSU study says yes
10. Doing more means changing less when it comes to gene response, new study shows
11. Columbia Nursing study exposes infection risks in home health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... 2017  The Allen Institute for Cell Science today ... one-of-a-kind portal and dynamic digital window into the human ... first application of deep learning to create predictive models ... and a growing suite of powerful tools. The Allen ... future publicly available resources created and shared by the ...
(Date:4/4/2017)... April 4, 2017   EyeLock LLC , a ... the United States Patent and Trademark Office (USPTO) has ... the linking of an iris image with a face ... represents the company,s 45 th issued patent. ... very timely given the multi-modal biometric capabilities that have ...
(Date:3/30/2017)... , March 30, 2017 The research ... system for three-dimensional (3D) fingerprint identification by adopting ground breaking 3D ... a new realm of speed and accuracy for use in identification, ... an affordable cost. ... ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... Ca (PRWEB) , ... August 16, 2017 , ... ... by changing into a different cell type. Many treatments for specific cancers, such ... prominent example of targeted treatment is androgen deprivation therapy for advanced prostate cancer. ...
(Date:8/16/2017)... , Aug. 16, 2017  This year,s edition of the Inc. ... in life sciences workforce solutions, has made the list for the third ... recognizes the nation,s fastest-growing private companies based on a set of quantitative ... which includes the fastest-growing companies in the Bay State ... Inc. 5000 ...
(Date:8/15/2017)... ... August 15, 2017 , ... Nanomedical ... and biotherapeutics development, announces the launch of the new NHS Agile biosensor ... kinetic binding data for a wide range of molecules, including small and large ...
(Date:8/15/2017)... ... August 15, 2017 , ... The Conference Forum and The ... through a series of upcoming panels and events. The partnership culminates with the ... Hotel in New York City. , “With our experience in producing the Immuno-Oncology 360° ...
Breaking Biology Technology: