Navigation Links
Study confirms how the body regulates high levels of CO2 in the blood
Date:6/11/2014

In a recently published study in the journal Experimental Physiology, Brazilian researchers have confirmed the importance of a specific group of neurons found in a region of the brain known as the retrotrapezoid nucleus (RTN) in detecting changes in carbon dioxide (CO2) levels and in modulating the activity of the neuronal groups that control respiratory activity.

Scientists from the Biomedical Sciences Institute of the University of So Paulo (USP) and the School of Dentistry at the So Paulo State University (Unesp) participated in the study.

"CO2 is important for regulating the acid-base balance of the blood. When the concentration of this gas becomes higher than normal, the blood tends to become more acidic, which promotes the activation of specialized sensors called chemoreceptors," said Eduardo Colombari, professor at the School of Dentistry at Unesp.

"Some of these chemoreceptors are located in the central nervous system; more precisely, on the ventrolateral surface of the medulla oblongata [the region of the brain responsible for neurovegetative control that forms the interface between the spinal cord and the mesencephalon] in the RTN," he explained.

According to Colombari, the neurons in this region express a specific marker that allows them to be identified. This marker consists of a transcription factor called Phox2b, which is involved in the cell differentiation of autonomic and respiratory neurons, that communicate with other neural groups responsible for controlling respiratory activity in order to keep CO2 levels within the physiological range.

Previous studies in the scientific literature, said Colombari, have suggested that various neuronal groups, such as the nucleus of the solitary tract, the raphe nuclei (which secrete serotonin), and the pontine and hypothalamic areas, were involved in the control of chemoreception (in this case, the detection and modulation of CO2 levels).

The group's work has demonstrated, however, that the respiratory changes caused by the increase in CO2 levels are compromised during the occurrence of selective destruction of the RTN neurons that express Phox2b.

The researcher further explained that the work illustrated how a small region of the brain contains neurons with a classic biochemical signature (Phox2b) which are involved in detecting and maintaining adequate levels of CO2, thus allowing the maintenance of homeostasis.

According to Colombari, advances in understanding the mechanisms involved in the perception of CO2 levels in the central nervous system could help prevent cases of sudden death in infants and adults in the future.


'/>"/>

Contact: Samuel Antenor
samuel@fapesp.br
55-113-838-4381
Fundao de Amparo Pesquisa do Estado de So Paulo
Source:Eurekalert

Related biology news :

1. Gum disease bacteria selectively disarm immune system, Penn study finds
2. CU Denver study finds serious challenges to New Urbanist communities
3. New study shows that oatmeal can help you feel full longer
4. New study finds text messaging program benefits pregnant women
5. Penn receives $10 million award to study asbestos adverse health effects, remediation
6. Study reveals rats show regret, a cognitive behavior once thought to be uniquely human
7. Breakthrough study solves plant sex mystery
8. Saving trees in tropics could cut emissions by one-fifth, study shows
9. Can mice mimic human breast cancer? MSU study says yes
10. Doing more means changing less when it comes to gene response, new study shows
11. Columbia Nursing study exposes infection risks in home health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... , ... June 21, 2017 , ... ... office in North Carolina, and engages Timothy Reinhardt to manage the new site. ... leadership at Pfizer Inc, with his most recent role as the Director of ...
(Date:6/22/2017)... ... 22, 2017 , ... For the months of May and ... Spotlight series on “Cell Therapy Regulation” for its regenerative medicine followship. ... unique regulatory challenges of stem cell medical research. , Stem cell clinical trials ...
(Date:6/22/2017)... ... June 22, 2017 , ... Charm Sciences, Inc. is pleased to ... was determined to be appropriate as a screening test at dairies and farms for ... EZ system, and the Charm EZ Lite system. These systems are a combination incubator ...
(Date:6/20/2017)... SQUARE, Pa. , June 20, 2017  Kibow ... is pleased to announce the issuance of a new ... gout or hyperuricemia by the U.S. Patent and Trademark ... Inc., a winner of the Buzz of Bio award ... , is akin to developing non-drug approaches to chronic ...
Breaking Biology Technology: