Navigation Links
Study by Pittsburgh researchers identifies possible vaccine target for chlamydia
Date:9/12/2007

Scientists at Childrens Hospital of Pittsburgh of UPMC have identified a potential target for the development of a vaccine against Chlamydia trachomatis, the most prevalent sexually transmitted bacterial infection in the world.

The researchers, led by Toni Darville, MD, chief of the Division of Pediatric Infectious Diseases at Childrens, identified a plasmid-deficient strain of Chlamydia that, when investigated in an animal model of genital tract infection, failed to cause disease. Plasmids are small molecules of DNA.

Results of their study are published in the Sept. 15 issue of the Journal of Immunology.

This finding represents a major step forward in our work to eventually develop a vaccine against chlamydial disease, said Dr. Darville, senior author of the study and also a professor of pediatrics and microbiology/immunology at the University of Pittsburgh School of Medicine. If we can identify plasmid-deficient derivatives of the C. trachomatis strains that infect humans, they would have the potential to serve as a vaccine against this disease.

Dr. Darville is considered one of the worlds foremost researchers of Chlamydia trachomatis, a bacterium which is the most frequently reported cause of sexually transmitted disease in the United States. Because symptoms are usually mild or absent, it can damage a womans reproductive organs and cause irreversible damage, including infertility, before a woman ever recognizes a problem.

In this study, a plasmid-deficient strain derived from Chlamydia muridarum was introduced to mice. The mice became infected but did not develop the trademark signs of chlamydial disease, particularly damage to the oviduct, the tube that carries eggs from the ovaries, according to Catherine M. OConnell, PhD, a researcher in Dr. Darvilles laboratory and first author of the study.

Not only did the mice not develop oviduct scarring after infection with the plasmid-deficient strain, we als
'/>"/>

Contact: Marc Lukasiak
marc.lukasiak@chp.edu
412-692-7919
Children's Hospital of Pittsburgh
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bioartificial kidney under study at MCG
2. Novel Asthma Study Shows Multiple Genetic Input Required; Single-gene Solution Shot Down
3. W.M. Keck Foundation funds study of friendly microbes
4. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
5. Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs
6. UCLA Study Shows One-Third of Drug Ads in Medical Journals Do Not Contain References Supporting Medical Claims
7. Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible
8. Study Links Ebola Outbreaks To Animal Carcasses
9. Genome-wide mouse study yields link to human leukemia
10. Breakthrough Microarray-based Technology for the Study of Cancer
11. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... rage. Thousands of scientists worldwide are conducting research on ... nanoparticles from sun creams can get through the skin ... products are as hazardous for the lungs as asbestos ... get into the blood via the intestinal flora, for ... – and the number of scientific projects is skyrocketing: ...
(Date:10/29/2014)... to as ,facultative, form part—together with other cells—of tissues ... cells from the others. However, they have a very ... stem cells again. This phenomenon is something that happens ... stimulate tissue growth, thus allowing the regeneration of the ... the underlying mechanism that allows these cells to ...
(Date:10/29/2014)... – Ghrelin is a hormone released by the stomach ... commonly viewed as a psychoactive substance that primarily affects ... food. , This knowledge, combined with findings from ... has the potential to stimulate alcohol craving. , Dr. ... and found that, as they had anticipated, alcohol craving ...
Breaking Biology News(10 mins):Nanosafety research: The quest for the gold standard 2Nanosafety research: The quest for the gold standard 3A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2Ghrelin stimulates an appetite for drinking alcohol 2
... VEGAS , Jan. 7, 2014 from ShowStoppers @ ... of securing consumer data on mobile and other digital devices, ... data once it leaves the device and enters the cloud. ... announced the formalization of its Biometric Open Standards Protocols (BOPS). ...
... This news release is available in Portuguese . ... is available in Portuguese . , ... goes beyond the presence or absence of wings. In a study published ... Keller and Patrcia Beldade from the Instituto Gulbenkian de Cincia (IGC, ...
... underrepresented among speakers at scientific meetings, both in absolute ... a new study suggests one way to address this ... published in mBio , the online open-access journal ... inclusion of at least one woman on a convening ...
Cached Biology News:Hoyos Labs Issues Biometric Open Protocol Standard for Safer Authentication 2Hoyos Labs Issues Biometric Open Protocol Standard for Safer Authentication 3Ants shape their thoraces to match the tasks they perform 2Ants shape their thoraces to match the tasks they perform 3Including women on convening committees increases women speakers at scientific meetings 2
(Date:10/31/2014)... (PRWEB) October 31, 2014 Following the ... a free learning webinar to introduce its new product ... directors and biostatisticians. , Launched in September, Formedix On ... suite of clinical trial automation tools. For the first ... web browser. And by introducing Formations – a revolutionary ...
(Date:10/31/2014)... 31, 2014 ENVIRON , ... announced today that Dr. Harvey Clewell III has ... will work closely with senior professionals in ENVIRON’s ... to serve at The Hamner Institutes for Health ... Carolina, where he is Director, Center for Human ...
(Date:10/30/2014)... October 30, 2014 The report “Fragrance ... by Application (Cosmetics & Toiletries, and Soaps & Detergents) ... 2019”, has defined and segmented the Fragrance Ingredients Market ... in terms of value. The market has been segmented ... America, Europe, Asia-Pacific, Latin America, and Rest of the ...
(Date:10/30/2014)... 30, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Naltrexone HCL information, including its definition, classification, application, ... overview. This research covers the international market analysis, ... industry analysis covering macroeconomic environment & economic situation ...
Breaking Biology Technology:Formedix to Introduce "Revolutionary" Clinical Trial Automation Software with Learning Webinar 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 2Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 3Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 4Fragrance Ingredients Market worth $17,104.21 Million by 2019 - New Report by MarketsandMarkets 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3
... 30 ChemRisk, a leading scientific,consulting firm, was ... examine,the recent publication by Institute for Agriculture and ... High Fructose Corn Syrup," and the,Environmental Health journal ... product sugar," by Dufault et al, 2009, and ...
... risk factors better than standard cholesterol test and traditional ... Traditional risk factors such as age, standard cholesterol ... predicting heart disease risk in younger, healthy adults with ... to a recent study published in Clinical Cardiology ...
... Mass., Jan. 30 Jeff Olson, Manager of Nucleic ... Enrichment of Genomic Loci for Targeted Sequencing Applications ... RainStorm micro-droplet technology on the new RDT 1000 instrument, ... (AGBT) conference on Friday, February 6th, in Marco Island, ...
Cached Biology Technology:Recent Reports Regarding Mercury and High Fructose Corn Syrup Flawed and Misleading 2Recent Reports Regarding Mercury and High Fructose Corn Syrup Flawed and Misleading 3Recent Reports Regarding Mercury and High Fructose Corn Syrup Flawed and Misleading 4Traditional Risk Factors Often Miss Heart Disease Warning Signs 2Traditional Risk Factors Often Miss Heart Disease Warning Signs 3Traditional Risk Factors Often Miss Heart Disease Warning Signs 4'Enrichment of Genomic Loci for Targeted Sequencing Application' Is Focus of 2009 AGBT Conference Workshop 2'Enrichment of Genomic Loci for Targeted Sequencing Application' Is Focus of 2009 AGBT Conference Workshop 3
Recombinant DNA polymerase from Thermus aquaticus expressed in E. coli; 5 units/uL; 25 tubes of 1, 000 units enzyme/tube w/ Buffer I...
Taq DNA Polymerase (cloned), 250 units. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzymes, Polymerases....
Request Info...
Request Info...
Biology Products: