Navigation Links
Study by NTU professors provides important insight into apoptosis or programmed cell death
Date:7/14/2009

A study by Nanyang Technological University (NTU)'s Assistant Professor Li Hoi Yeung, Assistant Professor Koh Cheng Gee and their team have made an important contribution to the understanding of the process that cells go through when they die. This process known as 'apoptosis' or programmed cell death, is a normal process in the human body which removes perhaps a million cells a second.

According to Professor Li, they discovered that during apoptosis, the cell's rescue mechanism is inhibited when certain proteins (i.e. 'anti-factors' that are necessary to keep a cell alive) are no longer able to enter the cell's nucleus, thus stopping the cell's ability to initiate its self-repair process.

In addition, they also discovered that the protein RanGTP, which is involved in the transportation of certain proteins into and out of the cell's nucleus, is reduced greatly during the early stages of apoptosis.

Under normal circumstances, there is a high distribution of RanGTP in the nucleus and a low concentration of RanGTP in the cytoplasm (the body enveloping the cell's nucleus). It is this gradient of RanGTP that exist across the nuclear-cytoplasmic boundaries that serves as a track and directs the transport of proteins and other molecules into and out of the nucleus. Hence, when the concentration of RanGTP is reduced in the nucleus, the RanGTP gradient collapses and the nuclear transport machinery subsequently shuts down.

Too little or too much apoptosis plays a role in a great many diseases. When programmed cell death does not work right, cells that should be eliminated may linger around and become immortal - for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer, Huntington and Parkinson diseases.

While it is established that cells undergo apoptosis when they are damaged by mechanical injury, exposed to death stimuli, or under stress, the mechanism that initiates apoptosis has not been comprehensively resolved. Thus the study by Professor Li, Professor Koh and their team at NTU have provided new insights on the process that cells go through while experiencing apoptosis.


'/>"/>

Contact: Hisham Hambari
mhisham@ntu.edu.sg
656-790-6447
Nanyang Technological University
Source:Eurekalert

Related biology news :

1. Probiotics help gastric-bypass patients lose weight more quickly, Stanford study shows
2. New study ranks hotspots of human impact on coastal areas
3. Work in mice will contribute to the study of hereditary diseases that lead to blindness
4. UAB study reveals bone coupling factor key to skeletal health
5. Army study improves ability to predict drinking water needs
6. Plant protein doorkeepers block invading microbes, study finds
7. Study finds role for parasites in evolution of sex
8. Canadian researchers set to study impact of nanomaterials on aquatic ecosystems
9. MS study offers theory for why repair of brains wiring fails
10. Oscar Pistorius: Previously confidential study results released on amputee sprinter
11. NSF provides $3.4 million to study climatically important Agulhas Current
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... , Jan. 6, 2017  Privately-held CalciMedica, Inc., ... in healthy volunteers of a novel calcium release-activated ... acute pancreatitis. Acute pancreatitis, sudden ... mild disorder, but can be very serious.  In severe ... sepsis, where extended hospital stays, time in the ...
(Date:1/3/2017)... Jan. 3, 2017 Onitor, provider of digital ... Onitor Track, an innovative biometric data-driven program designed to ... month at the 2017 Consumer Electronics Show (CES) in ... In the U.S., the World Health Organization (WHO), have ... of adults who are overweight or obese. WHO also ...
(Date:12/19/2016)... , España y TORONTO , 19 de diciembre ... Northern Biologics Inc. que permitirá el desarrollo acelerado de MSC-1, un ... en varios tipos de tumor en 2017, con múltiples sitios previstos ... ... clase con objetivo en el factor inhibidor de leucemia (LIF), una ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... -- Research and Markets has announced the addition of ... Application - Global Opportunity Analysis and Industry Forecast, 2014-2022" report ... ... projected to reach $15,737 million by 2022 from $6,521 in 2015, ... Omic technologies segment accounted for more than half of ...
(Date:1/19/2017)... and HOUSTON , Jan. ... Prenatal") today announced the formation of its Medical/Clinical ... clinicians and industry veterans who enhance the range ... it accelerates development of its novel prenatal diagnostic ... medical, clinical and strategic guidance for the company,s ...
(Date:1/19/2017)... Research and Markets ... has announced the addition of the ... 2025" report to their offering. Report ... provides a detailed analysis on current and future market trends to identify ... market values as the base numbers Key market trends ...
(Date:1/19/2017)... ... 19, 2017 , ... November Research Group, LLC, a global ... device manufacturers and regulators, is proud to announce the worldwide release of PRIMO ... to provide product vigilance departments with the flexibility and ease of use of ...
Breaking Biology Technology: