Navigation Links
Study by NTU professors provides important insight into apoptosis or programmed cell death
Date:7/14/2009

A study by Nanyang Technological University (NTU)'s Assistant Professor Li Hoi Yeung, Assistant Professor Koh Cheng Gee and their team have made an important contribution to the understanding of the process that cells go through when they die. This process known as 'apoptosis' or programmed cell death, is a normal process in the human body which removes perhaps a million cells a second.

According to Professor Li, they discovered that during apoptosis, the cell's rescue mechanism is inhibited when certain proteins (i.e. 'anti-factors' that are necessary to keep a cell alive) are no longer able to enter the cell's nucleus, thus stopping the cell's ability to initiate its self-repair process.

In addition, they also discovered that the protein RanGTP, which is involved in the transportation of certain proteins into and out of the cell's nucleus, is reduced greatly during the early stages of apoptosis.

Under normal circumstances, there is a high distribution of RanGTP in the nucleus and a low concentration of RanGTP in the cytoplasm (the body enveloping the cell's nucleus). It is this gradient of RanGTP that exist across the nuclear-cytoplasmic boundaries that serves as a track and directs the transport of proteins and other molecules into and out of the nucleus. Hence, when the concentration of RanGTP is reduced in the nucleus, the RanGTP gradient collapses and the nuclear transport machinery subsequently shuts down.

Too little or too much apoptosis plays a role in a great many diseases. When programmed cell death does not work right, cells that should be eliminated may linger around and become immortal - for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer, Huntington and Parkinson diseases.

While it is established that cells undergo apoptosis when they are damaged by mechanical injury, exposed to death stimuli, or under stress, the mechanism that initiates apoptosis has not been comprehensively resolved. Thus the study by Professor Li, Professor Koh and their team at NTU have provided new insights on the process that cells go through while experiencing apoptosis.


'/>"/>

Contact: Hisham Hambari
mhisham@ntu.edu.sg
656-790-6447
Nanyang Technological University
Source:Eurekalert

Related biology news :

1. Probiotics help gastric-bypass patients lose weight more quickly, Stanford study shows
2. New study ranks hotspots of human impact on coastal areas
3. Work in mice will contribute to the study of hereditary diseases that lead to blindness
4. UAB study reveals bone coupling factor key to skeletal health
5. Army study improves ability to predict drinking water needs
6. Plant protein doorkeepers block invading microbes, study finds
7. Study finds role for parasites in evolution of sex
8. Canadian researchers set to study impact of nanomaterials on aquatic ecosystems
9. MS study offers theory for why repair of brains wiring fails
10. Oscar Pistorius: Previously confidential study results released on amputee sprinter
11. NSF provides $3.4 million to study climatically important Agulhas Current
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... 24, 2017 Janice Kephart , ... Identity Strategy Partners, LLP (IdSP) , today issues ... President Trump,s March 6, 2017 Executive Order: ... vetting can be instilled with greater confidence, enabling ... all refugee applications are suspended by until at ...
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... 2017 No two people are believed ... New York University Tandon School of Engineering and ... that partial similarities between prints are common enough ... phones and other electronic devices can be more ... lies in the fact that fingerprint-based authentication systems ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... 23, 2017 , ... Cambridge Semantics , the leading provider of Big ... World Conference and Expo in Boston May 23-25 with a featured speaker and ... Smart Data Lake is also a finalist for the Best of Show award. , ...
(Date:5/22/2017)... ... May 22, 2017 , ... Cancer ... exhibiting in booth B2 at the Association for Pathology Informatics Annual Summit ... In addition to demonstrating its Cancer Diagnostic Cockpit and Consultation Portal, Inspirata will ...
(Date:5/19/2017)... ... May 19, 2017 , ... The University City Science ... technologies ripe for commercialization, and who are affiliated with the 21 partner academic ... proposals. QED, now in its tenth round, is the first multi-institutional proof-of-concept program ...
(Date:5/18/2017)... ... May 17, 2017 , ... NDA Partners Chairman Carl Peck, MD , ... Advantar Laboratories and President of Pharmaceutical Development Business Unit of Cardinal Health, has joined ... Cardinal Health, he was former Chief Operating Officer at Anaborex, Senior VP and General ...
Breaking Biology Technology: