Navigation Links
Study breaks blood-brain barriers to understanding Alzheimer's
Date:12/13/2013

ls and along brain blood vessels. Surprisingly, the brains of the crossbred mice had enhanced neuronal cell death and extensive neurofibrillary tangles in the hippocampus and cerebral cortex, regions that are typically affected during Alzheimer's.

"Our results suggest that damage to the vascular system may be a critical step in the development of full-blown Alzheimer's disease pathology," said Dr. Zlokovic.

Further experiments suggested that pericytes may transport beta-amyloid across the blood-brain barrier into the blood and showed that crossbreeding the mice slowed the rate at which beta-amyloid was cleared away from nerve cells in the brain.

Next, the researchers addressed how beta-amyloid may affect the vascular system. The crossbred mutants had more pericyte death and more damage to the blood-brain barrier than the PDGFR-beta mutant mice, suggesting beta-amyloid may enhance vascular damage. The investigators also confirmed previous findings showing that beta-amyloid accumulation leads to pericyte death.

Dr. Zlokovic and his colleagues concluded that their results support a two-hit vascular hypothesis of Alzheimer's. The hypothesis states that the toxic effects of increased beta-amyloid deposition on pericytes in aged blood vessels leads to a breakdown of the blood-brain barrier and a reduced ability to clear amyloid from the brain. In turn, the progressive accumulation of beta-amyloid in the brain and death of pericytes may become a damaging feedback loop that causes dementia. If true, then pericytes and other blood-brain barrier cells may be new therapeutic targets for treating Alzheimer's disease.


'/>"/>

Contact: Christopher G Thomas
nindspressteam@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Disease, not climate change, fueling frog declines in the Andes, study finds
2. With new study, aquatic comb jelly floats into new evolutionary position
3. Study of rodent family tree puts brakes on commonly held understanding of evolution
4. New study highlights key role soil structure plays in water uptake by crops
5. CNIO study chosen as discovery of the year in regenerative medicine
6. Study finds biomaterials repair human heart
7. Harvard study shows sprawl threatens water quality, climate protection, and land conservation gains
8. Study shows first link between altitude and concussion
9. Life Technologies Collaborates with Canadian Centre for DNA Barcoding on Species Biodiversity Study
10. Penn Medicine team reports on study of first 59 leukemia patients who received cell therapy
11. Study reveals gene expression changes with meditation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study breaks blood-brain barriers to understanding Alzheimer's
(Date:4/10/2015)... DUBLIN , April 10, 2015 ... the addition of the "Security Competitive Profiles - ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to ... solutions to the market, with a company focus on ... solution anticipated. Winning opportunities in the ...
(Date:4/2/2015)... April 2, 2015 In ... by far outperforms the strongest competitors, showing outstanding ... accuracy, the system is capable of a throughput ... proves up to be ten times faster than ... runner-up performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
(Date:4/1/2015)... , Apr. 1, 2015  NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... smart wallets is underway to early access pre-order customers. ... includes usage at retail outlets including Walmart, Target, AT&T, ... report Wocket was accepted at all outlets and very ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... the Electronic Nose, which has the potential to diagnose ... grant from Grand Challenges Canada and the Bill & ... testing of this ground-breaking technology. The ... able to detect TB immediately and non-invasively from the ...
... family of compounds that includes one of the most ... treatments. But the difficulty producing these complex molecules in ... family for further drug leads. Now, a group of ... step toward the goal of synthetically producing Taxol and ...
... name "Sleeping Beauty" has helped to unlock vital clues ... A study published today used the Sleeping Beauty transposon ... drive colorectal cancer, identifying many more than previously thought. ... human cancer, which provides strong evidence that they are ...
Cached Biology News:Creating an 'electronic nose' to sniff out tuberculosis from a patient's breath 2Scripps research team achieves critical step to opening elusive class of compounds to drug discovery 2Scripps research team achieves critical step to opening elusive class of compounds to drug discovery 3Scripps research team achieves critical step to opening elusive class of compounds to drug discovery 4Researchers discover genes involved in colorectal cancer 2
(Date:5/4/2015)... May 4, 2015   Intrexon Corporation (NYSE: ... quarter 2015 financial results after the market closes on ... call that day at 5:30 PM ET to discuss ... The conference call may be accessed by dialing ... join the "Intrexon Conference Call."  Participants may also access ...
(Date:5/4/2015)... Wheaton, Illinois (PRWEB) May 04, 2015 ... treatment options for patients with arm and hand ... rehabilitation exoskeleton at its Oakbrook Terrace network site. ... foundation, the Armeo®Spring is a highly-regarded treatment option ... In acquiring the Armeo®Spring, Marianjoy becomes one of ...
(Date:5/1/2015)... May 01, 2015 OncoTAb, Inc., ... Charlotte) spin-out company, announced that Pinku Mukherjee, Ph.D. has ... UNC Board of Governors’ highest faculty honor. Mukherjee received ... welfare , for her innovative research and development of ... Award represents a crowning moment in my scientific career,” ...
(Date:5/1/2015)... 2015 Pfenex Inc. (NYSE MKT: PFNX), ... of biosimilar therapeutics including high value and difficult ... quarter 2015 financial results will be released on ... market. At 8:30 am Eastern Time, Pfenex management will ... results and provide a business update. A press release ...
Breaking Biology Technology:Intrexon to Announce First Quarter 2015 Financial Results on Monday, May 11, 2015 2Marianjoy Acquires Armeo®Spring Arm and Hand Rehabilitation Exoskeleton at Oakbrook Terrace Facility 2OncoTAb CSO Awarded the University of North Carolina’s O. Max Gardner Award 2Pfenex To Report First Quarter 2015 Results and Provide Business Update on Thursday, May 14, 2015 2
... Novavax, Inc. (Nasdaq:,NVAX) today announced financial results for the first ... loss per share) for the first,quarter of 2008 compared to ... the first quarter of 2007. Total cash and short-term investments,as ... million as of,December 31, 2007. The cash burn for the ...
... China-Biotics,Inc. (OTC Bulletin Board: CHBT) ("China-Biotics," "the Company"), ... development,marketing and distribution of probiotics products, today announced ... at Qing Pu, Shanghai., "The new plant ... cornerstone of our,growth strategy. We have put over ...
... Netherlands, May 9 /PRNewswire/,-- University Hospitals Case ... the Companies have the intention to found ... and medical imaging,services to clients that are ... in world wide studies., University Hospitals ...
Cached Biology Technology:Novavax Reports First Quarter 2008 Financial Results 2Novavax Reports First Quarter 2008 Financial Results 3Novavax Reports First Quarter 2008 Financial Results 4Novavax Reports First Quarter 2008 Financial Results 5Novavax Reports First Quarter 2008 Financial Results 6Novavax Reports First Quarter 2008 Financial Results 7Novavax Reports First Quarter 2008 Financial Results 8China-Biotics, Inc. Completes Foundation for Its New Plant 2University Hospitals Case Medical Center, Cleveland, USA and Cardialysis BV, Rotterdam, the Netherlands Enter Strategic Alliance to Found Cardialysis Cleveland 2University Hospitals Case Medical Center, Cleveland, USA and Cardialysis BV, Rotterdam, the Netherlands Enter Strategic Alliance to Found Cardialysis Cleveland 3
... Incubator/Shaker HT is designed for ... Incubator/Shaker HT is ideal for ... and primer extension assays. iEMS ... a one-cabinet model, allowing the ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
...
... PTOs are internucleotide modifications, where ... is replaced by a sulphur atom. This ... PTOs are available as Full-PTOs ... Oligonucleotides with thio-caps Several ...
Biology Products: