Navigation Links
Study advances use of stem cells in personalized medicine
Date:11/26/2012

grammed to analyze the effects, the researchers quickly identified eight compounds for further testing, of which one SKF-86466 ultimately showed promise for stopping or reversing the disease process at the cellular level.

Lee says a clinical trial with SKF-86466 might not be feasible because of the small number of Riley-Day patients worldwide, but suggests that a closely related version of the compound, one that has already been approved by the U.S. Food and Drug Administration for another use, could be employed for the patients after a few tests.

The implications of the experiment reach beyond Riley-Day syndrome, however. "There are many rare, 'orphan' genetic diseases that will never be addressed through the costly current model of drug development," Lee explains. "We've shown that there may be another way forward to treat these illnesses."

Another application of the new stem cell process could be treatments tailored not only to an illness, but also to an individual patient, Lee says. That is, iPSCs could be made for a patient, then used to create a laboratory culture of, for example, pancreatic cells, in the case of a patient with type 1 diabetes. The efficacy and safety of various drugs could then be tested on the cultured cells, and doctors could use the results to help determine the best treatment. "This approach could move much of the trial-and-error process of beginning a new treatment from the patient to the petri dish, and help people to get better faster," says Lee.


'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
2. Algae Biomass Organization hails new UCSD study showing saltwater algae viable for biofuels
3. Study reveals the proteins expressed by human cytomegalovirus
4. New public gut bacteria study expected to reach around world
5. Researchers study links between conflict and fisheries in East Africa
6. NJIT civil engineer receives NSF grant to study storms impact on Jersey Shore
7. New whale shark study used metabolomics to help understand shark and ray health
8. NIST study suggests carbon nanotubes may protect DNA from oxidation
9. New study finds milk-drinking kids reap physical benefits later in life
10. New brain gene gives us edge over apes, study suggests
11. Study investigates headshaking in horses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/10/2015)... 2015 Research and Markets ( ... "Security Competitive Profiles - NEC" report to their ... NEC will continue to supply a range of IT ... a company focus on the development of a Big ... opportunities in the Asia-Pacific region ...
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. ... a biometric authentication company focused on the growing ... filed provisional patent 62/143028 for MINIATURE, ... ENERGY TRANSFER  NXT-ID introduces a new ... This patent surrounds the use of miniature antenna ...
(Date:4/2/2015)... According to preliminary estimates Fingerprint ... higher than 125 MSEK. This exceeds the guidance provided ... revenues for Q1 2015 would be in line with ... 2014. The operating result for the first quarter is ... report will as previously communicated be published on May ...
Breaking Biology News(10 mins):NEC Security Competitive Profile 2015 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4Fingerprint Cards Revises Revenues for Q1 2015 2
... and successful lab tests of "killer paper," a material ... that helps preserve foods by fighting the bacteria that ... Langmuir , contains a coating of silver nanoparticles, which ... colleagues note that silver already finds wide use as ...
... tau protein deposits in the brain are characteristic features ... area of the brain that plays a central role ... appears that the toxic effect of tau protein is ... off. Researchers from the Max Planck Research Unit for ...
... Israel,s Wolf Foundation, whose stated mission is "to promote ... named Whitehead Institute Founding Member Rudolf Jaenisch a recipient ... Jaenisch will share this year,s prize with Kyoto University,s ... "their groundbreaking contribution to stem cell research." ...
Cached Biology News:Tau-induced memory loss in Alzheimer's mice is reversible 2Tau-induced memory loss in Alzheimer's mice is reversible 3Whitehead member Rudolf Jaenisch honored for groundbreaking stem cell research 2
(Date:4/17/2015)... 17, 2015 BellBrook Labs announced ... support for the powerful Orthogonal Pooled Screening (OPS) ... Center at the Lankenau Institute for Medical Research ... to measurably improve successful drug discovery outcomes using ... rare, drug-like libraries available nowhere else, coupled to ...
(Date:4/16/2015)... 16, 2015 Capillus, LLC announces ... physician network in Europe and Asia. The Miami-based ... Fernando Bermúdez, former Business Development Director of Svenson ... veteran, Mr. Bermúdez’s professional achievements include increasing the ... while also penetrating the Portuguese marketplace with centers ...
(Date:4/16/2015)... 16, 2015 OncoTAb, Inc., ... (UNC Charlotte) spin-out company, announced today the appointment ... M.D., as Chief Operating Officer (COO). Cooper brings ... in developing clinical diagnostic and biotechnology platforms in ... , Cooper’s extensive career transcends the field of ...
(Date:4/16/2015)... /CNW/ - Bioenterprise Corporation is pleased to announce that it ... Charlottetown , PEI.  Bioenterprise has established a 3-year ... for the commercialization of agricultural technologies and innovations. ... ADAPT.  They have been at the heart of agri-innovation ... Dave Smardon , President & CEO of Bioenterprise ...
Breaking Biology Technology:BellBrook Labs and Lankenau Institute Partner to Accelerate Drug Discovery using Orthogonal Pooled Screening 2Capillus, LLC Extends Laser Hair Therapy Products to Europe and Asia 2OncoTAb Names Dr. David L. Cooper as COO 2Bioenterprise Corporation Expands into the Maritimes 2
... - The University of Wisconsin Medical Foundation ... the Medical Foundation's clinical data and to improve the ... has choosen QDX Platform V Integration Services from ... company based in Englewood, Colorado. , ,The Medical Foundations ...
... Inc. , a provider of single-molecule DNA analysis technology, announced ... deadly type of brain tumor, known as oligodendroglioma. OpGen, based ... Center and professor of genetics and chemistry at the ... Schwartz . , ,Optical mapping, invented by Schwartz, will enable ...
... A few weeks ago, I referred to offshore outsourcing ... rapidly becoming an issue de lannee (an election year ... and increasing questions about the economic future of the ... spectrum from the contenders for the Democratic presidential nomination ...
Cached Biology Technology:UW Medical Foundation Integrates Medical Records 2OpGen joins UW, Henry Ford Heath in Improving Brain Tumor Treatment 2The Great Offshore Outsourcing Debate 2
WIF-1 (N-20)...
Mouse monoclonal [1.T.4] to WAVE 1 ( Abpromise for all tested applications). Antigen: His6 fusion protein corresponding to full-length rat WAVE1. Entrez Gene ID: 8936...
IgG2b, k APC clone A95-1, Isotype Rat IgG2b, kappa, 0.1 mg ....
...
Biology Products: