Navigation Links
Study advances use of stem cells in personalized medicine
Date:11/26/2012

Johns Hopkins researchers report concrete steps in the use of human stem cells to test how diseased cells respond to drugs. Their success highlights a pathway toward faster, cheaper drug development for some genetic illnesses, as well as the ability to pre-test a therapy's safety and effectiveness on cultured clones of a patient's own cells.

The project, described in an article published November 25 on the website of the journal Nature Biotechnology, began several years ago, when Gabsang Lee, D.V.M., Ph.D., an assistant professor at the Johns Hopkins University School of Medicine's Institute for Cell Engineering, was a postdoctoral fellow at Sloan-Kettering Institute in New York. To see if induced pluripotent stem cells (iPSCs) could be used to make specialized disease cells for quick and easy drug testing, Lee and his colleagues extracted cells from the skin of a person with a rare genetic disease called Riley-Day syndrome, chosen because it affects only one type of nerve cell that is difficult if not impossible to extract directly from a traditional biopsy. These traits made Riley-Day an ideal candidate for alternative ways of generating cells for study.

In a so-called "proof of concept" experiment, the researchers biochemically reprogrammed the skin cells from the patient to form iPSCs, which can grow into any cell type in the body. The team then induced the iPSCs to grow into nerve cells. "Because we could study the nerve cells directly, we could for the first time see exactly what was going wrong in this disease," says Lee. Some symptoms of Riley-Day syndrome are insensitivity to pain, episodes of vomiting, poor coordination and seizures; only about half of affected patients reach age 30.

In the recent research at Johns Hopkins and Memorial Sloan-Kettering, Lee and his co-workers used these same lab-grown Riley-Day nerve cells to screen about 7,000 drugs for their effects on the diseased cells. With the aid of a robot pro
'/>"/>

Contact: Shawna Williams
shawna@jhmi.edu
410-955-8236
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
2. Algae Biomass Organization hails new UCSD study showing saltwater algae viable for biofuels
3. Study reveals the proteins expressed by human cytomegalovirus
4. New public gut bacteria study expected to reach around world
5. Researchers study links between conflict and fisheries in East Africa
6. NJIT civil engineer receives NSF grant to study storms impact on Jersey Shore
7. New whale shark study used metabolomics to help understand shark and ray health
8. NIST study suggests carbon nanotubes may protect DNA from oxidation
9. New study finds milk-drinking kids reap physical benefits later in life
10. New brain gene gives us edge over apes, study suggests
11. Study investigates headshaking in horses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... new method for measuring and imaging how quickly blood ... better understand how drug abuse affects the brain, which ... and lead to better treatment options for recovering drug ... researchers from Stony Brook University in New York, USA ... today in The Optical Society,s (OSA) open-access journal ...
(Date:8/28/2014)... . Cars, planes ... of sophisticated assembly lines. Mobile assembly carriers, on to which ... assembly lines. In the case of a car body, the ... a precise spatial and chronological sequence, resulting in a complete ... of such an assembly line at molecular level has been ...
(Date:8/28/2014)... Oregon, northern California, and Alaska totaled 515 million board ... an increase of more than 10 percent compared to ... Pacific Northwest Research Station reported today. During this same ... to 247 million board feet. , The total value ... percent to $390 million in the same quarter, while ...
Breaking Biology News(10 mins):This is your brain's blood vessels on drugs 2This is your brain's blood vessels on drugs 3Nanoscale assembly line 2Nanoscale assembly line 3West coast log exports up, lumber exports down in second quarter of 2014 2
... 2011A compact, self-contained, automated system for surveillance and screening ... infectious diseases is a step closer to reality, thanks ... University of California Los Angeles School of Public Health, ... LANL and the UCLA School of Public Health will ...
... New Haven, Conn. Triceratops and Torosaurus have ... a new discovery traces the giants, family tree further back ... reigned long before its more well-known descendants, making it the ... species, called Titanoceratops after the Greek myth of ...
... is available in French and German . ... of public attention. In particular silver nanoparticles are being investigated ... regulatory authorities. The assumption behind this interest is that they ... Bernd Nowack and Harald Krug, together with Murray Heights of ...
Cached Biology News:LANL to certify automated influenza surveillance system 2LANL to certify automated influenza surveillance system 3Newly discovered dinosaur likely father of Triceratops 2Nanosilver: A new name -- well-known effects 2Nanosilver: A new name -- well-known effects 3
(Date:8/28/2014)... converters are important devices in spintronics, an electronic ... of electrons but also on their spin and ... of electric into magnetic signals and vice versa. ... from the Institute of Physics at Johannes Gutenberg ... UK, Prague, and Japan, has for the first ...
(Date:8/28/2014)... WA (PRWEB) August 28, 2014 Sterlitech ... Filtration’s polymeric membranes to its stable of products ... available molecular weight cut-offs and include membrane filters with ... steady increase in customer demand for our membrane process ... greater variety of flat sheet membranes,” explains Sterlitech President ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 Earlier this ... University in partnership with the U.S. Air Force ... biofuel. The results indicated that this type of fuel ... feedstock and will be important to America’s Eco friendly ... now has a mandate to become independent of foreign ...
(Date:8/27/2014)... Austin, TX (PRWEB) August 27, 2014 ... $6 million in Series B funding and secured Otter ... and investment capital will accelerate commercialization of GGI’s Agriplier™ ... multiple crop types. , “Since our first meeting, ... commitment to the biological product space,” said Alan Sobba, ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3
... screening and selection process for the next conferences demonstrating class ... the class has been identified, and Ill be busy until ... number of new products introduced at Februarys DEMO to 70. ... to get a sense of significant issues and trends that ...
... , Diseases like Parkinson's, Alzheimer's, juvenile diabetes ... including my own. Stem cell research, which is being ... some of these diseases. But these cures will continue to ... in the way of the vital work of scientists. , ...
... Wallace H. Coulter Foundation , named for the late ... at UW-Madison a five-year, $580,000 annual grant for pursuing ... research to get it ready for applications in the ... a decision will be made on continuing aid by ...
Cached Biology Technology:DEMO 2006: A sea change is coming 2DEMO 2006: A sea change is coming 3Standing up for stem cell research 2Standing up for stem cell research 3UW Biomedical Engineering awarded $2.9 million research grant 2
...
... for serial preparation of ... including cytosol/particulate/cytoskeleton/nuclear fractions from ... fractions can directly be ... such as 2-D gel/Western ...
Wheat Germ Agglutinin (WGA) PS SPA Imaging Bead, 2 g. Category: Leadseeker Beads....
... steadylite plus assay system offers ... sensitivity, Designed for batch-processing systems, ... higher density microplates such as ... free, Convenient storage conditions ( ...
Biology Products: