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Study Shows Sutro Biopharma's Biochemical Protein Synthesis Technology Enables Rapid Production and Scale-Up of Biopharmaceuticals
Date:5/19/2011

SAN FRANCISCO, May 19, 2011 /PRNewswire/ -- Sutro Biopharma, a biopharmaceutical company developing novel and biosuperior protein therapeutics with improved pharmaceutical properties, today announced that a study published in the July issue of Biotechnology and Bioengineering demonstrates that the company's biochemical protein synthesis technology platform enables fast and high-yield protein synthesis and scale-up with straightforward downstream purification processes.

In the study, the fully bioactive cytokine human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) was produced at linearly scalable levels from frozen extract of Sutro's E.coli-based open cell-free synthesis (OCFS) system. The disulfide-bonded biotherapeutic protein was produced at titers of 700 mg/L in 10 hours, demonstrating the potential of the company's technology for cGMP production.

"The study showed that Sutro's biochemical protein synthesis technology platform provides a robust, linearly-scalable system that allows the industrial production of disulfide-bonded proteins such as GM-CSF, and since the study was published, we have been able to double production efficiency per batch," said Christopher Murray, Ph.D., vice president of research at Sutro Biopharma and senior author of the publication. "The company's platform also enables the synthesis of proteins that contain site-specific non-natural amino acids as well as proteins that cannot be expressed using conventional technologies, allowing us to explore novel protein therapeutics that have been inaccessible, and even unimaginable, until now."

The authors extended and optimized the E. coli-based system that was developed by James R. Swartz, Sc.D., director and founder of Sutro Biopharma, to this OCFS system for high-level production of rhGM-CSF. The production capacity of the activated extract after freezing and storage at -4
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SOURCE Sutro Biopharma
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