Navigation Links
Study: Probiotics reduce stress-induced intestinal flare-ups
Date:3/14/2013

ANN ARBOR, Mich. For those with irritable bowel syndrome who wonder if stress aggravates their intestinal disorder, a new University of Michigan Health System study shows it's not all in their head.

Researchers revealed that while stress does not cause IBS, it does alter brain-gut interactions and induces the intestinal inflammation that often leads to severe or chronic belly pain, loss of appetite and diarrhea.

Stress has a way of suppressing an important component called an inflammasome which is needed to maintain normal gut microbiota, but probiotics reversed the effect in animal models, according to findings published online ahead of print in Gastroenterology.

"The effect of stress could be protected with probiotics which reversed the inhibition of the inflammasome," says senior study author and gastroenterologist John Y. Kao, M.D., associate professor of internal medicine at the University of Michigan. "This study reveals an important mechanism for explaining why treating IBS patients with probiotics makes sense."

Probiotics are live bacteria that help grow the gut-dwelling "good" bacteria that keep pathogens in check, aid digestion and nutrient absorption and contribute to immune function.

U-M researchers including Chung Owyang, M.D., chief of the U-M Division of Gastroenterology, Gary Huffnagle, Ph.D., professor of pulmonary and critical care, and infectious disease expert Vincent Young, M.D., Ph.D., were able to identify the way stress significantly altered the composition of gut bacteria and the role of probiotics.

Maintaining healthy microbiota requires action by nucleotide-binding oligomerization domain protein-like receptors, pyrin-domain containing (NLRP)-6 inflammasomes. But when stressed, mice produced corticotropin-releasing hormone (CRH) that prevented inflammasomes from doing their job.

Inhibiting inflammosomes alters the composition of the gut, leading to intestinal inflammation. In the study, pretreatment with probiotic therapy reduced inflammation in mice with stress-induced small bowel inflammation.

"Additional clinical study is required to determine the optimal probiotic therapy," says Kao. "Patients can start living healthier lifestyles to improve their gut microbiota such as adding more fruits and vegetables to their diet, and looking for ways to keep stress in check."


'/>"/>

Contact: Shantell M. Kirkendoll
smkirk@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Related biology news :

1. Study: Antibiotics are unique assassins
2. International study: Excess dietary salt may drive the development of autoimmune diseases
3. Influenza study: Meet virus new enemy
4. Study: Resveratrol shows promise to protect hearing, cognition
5. Nature Methods study: Using light to control cell clustering
6. Study: Viral reactivation a likely link between stress and heart disease
7. Study: Odd biochemistry yields lethal bacterial protein
8. International study: Where theres smoke or smog, theres climate change
9. UT study: Students who are more physically fit perform better academically
10. New study: Many flame retardants in house dust -- unsafe levels
11. Study: DNA barcoding can ID natural health products
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
(Date:4/17/2017)... 2017 NXT-ID, Inc. (NASDAQ: NXTD ) ... of its 2016 Annual Report on Form 10-K on Thursday April ... ... in the Investor Relations section of the Company,s website at ... at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... PUNE, India , April 13, 2017 According ... Identity Proofing, Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication ... by MarketsandMarkets™, the IAM Market is expected to grow from USD 14.30 ... Annual Growth Rate (CAGR) of 17.3%. ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , ... of Cancer Research, London (ICR) and ... with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple ... as MUK nine . The University of ... is partly funded by Myeloma UK, and ICR will perform ...
(Date:10/10/2017)... ... , ... San Diego-based team building and cooking events company, Lajollacooks4u, has unveiled ... bold new look is part of a transformation to increase awareness, appeal to new ... , It will also expand its service offering from its signature gourmet cooking classes ...
(Date:10/10/2017)... Parks Associates announced today that Tom Kerber , Director ... , October 11 in Scottsdale, Arizona . Kerber will ... safety and security products impact the competitive landscape. ... Parks Associates: Smart Home Devices: Main Purchase Driver ... "The residential security market has experienced continued growth, and the introduction of ...
(Date:10/9/2017)... 9, 2017  BioTech Holdings announced today identification ... its ProCell stem cell therapy prevents limb loss ... Company, demonstrated that treatment with ProCell resulted in ... as compared to standard bone marrow stem cell ... in reduction of therapeutic effect.  ...
Breaking Biology Technology: