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Study: Preventive use of one form of natural vitamin E may reduce stroke damage
Date:7/5/2011

ped the brain's communication network, represented by white matter fiber pathways. The sophisticated video images of the stroke-affected brain showed major gaps in this fiber network in the brains of animals that received no supplementation. The fiber connections were protected in the brains of dogs that received TCT.

Images of the blood vessels in the animals' brains showed different responses in the brain blood circulation based on whether or not they had received preventive treatment. The researchers used a scoring system to determine how much of the collateral circulatory system was activated in response to the blocked blood flow associated with the stroke. The score in treated dogs was almost twice as high as that in untreated animals.

"This function in the brain is similar in humans and large mammals, which underscores the significance of these findings," said Cameron Rink, first author of the study and an assistant professor of vascular surgery at Ohio State.

Additional examination of the affected brain tissue showed that the TCT supplementation appeared to support arteriogenesis, a process by which collateral arteries remodel themselves into larger vessels so they can bypass the site of blockage. Genes associated with this process were more active in the affected brain tissue from treated animals than were those from untreated dogs.

Preventive use of TCT, a natural vitamin, is safe and should be embraced as a preventive therapy along with aspirin, a commonly prescribed medicine to prevent a stroke, said Sen, who is also a deputy director of Ohio State's Davis Heart and Lung Research Institute.

"Though most of us have no idea if we are at risk for stroke, a sizable population has had a ministroke and is therefore at high risk for a large stroke. If I had a ministroke, why would I not take something that would minimize my damage during a stroke?" Sen said. "And this is not a drug; it is a nutritional countermeasure
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Contact: Chandan Sen
chandan.sen@osumc.edu
614-247-7786
Ohio State University
Source:Eurekalert

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