Navigation Links
Study: Metformin for breast cancer less effective at higher glucose concentrations
Date:10/24/2013

A University of Colorado Cancer Center study published online this month in the journal Cell Cycle shows that breast cancer cell growth, motility and aggression is promoted by excess glucose, as experienced by patients with diabetes and metabolic syndrome. The study also showed that patients with high glucose may require higher doses of the drug metformin to achieve the same anti-cancer activity as patients with normal glucose levels.

Metformin, the most common first-line drug in the treatment of type-2 diabetes, has been shown in previous studies to reduce breast cancer risk, improve survival, and increase the effectiveness of chemotherapy. Numerous Phase III clinical trials are currently evaluating the benefits and best uses of metformin in breast cancer patients.

"We show that metformin works differently in high- compared to low-glucose conditions. Not only does it require a higher concentration of metformin to be active in high-glucose conditions, but we report that the drug regulates different genes within cancer cells at high as compared to normal glucose levels," says Ann Thor, MD, CU Cancer Center investigator, Todd Professor of Pathology at the University of Colorado School of Medicine, and the study's principal investigator.

The study evaluated the effects of metformin on 17 breast cancer cell lines representing each of the molecular subtypes of the disease, at varying glucose levels.

"Commonly, lab studies of metformin are performed with very high glucose concentrations about 17 millimols of glucose per liter. But the average glucose level in healthy humans is only about one third of that dose about 5 millimols per liter. And individuals with diabetes may have glucose at 10 millimols per liter. We wanted to study metformin activity under these conditions," Thor says.

So the question was this: how would metformin perform in breast cancer cells grown at more realistic, human levels of glucose?


'/>"/>
Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study: Death by moonlight? Not always
2. Study: Acidity can change cell membrane properties
3. Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression
4. Rutgers study: Worms may shed light on human ability to handle chronic stress
5. UT study: Chemical in antibacterial soaps may harm nursing babies
6. Study: Pedometer program helps motivate participants to sit less, move more
7. Study: MicroRNA cooperation mutes breast cancer oncogenes
8. Study: Environmental policies matter for growing megacities
9. Study: Widespread test-and-treat HIV policies could increase dangerous drug resistance
10. Study: Probiotics reduce stress-induced intestinal flare-ups
11. Study: Antibiotics are unique assassins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2015)... , Aug. 17, 2015 Research ... addition of the "Global Biometric Authentication & ... - Estimation & Forecast, 2015-2020" report to ... authentication and identification systems market is expected to ... 2015 to 2020 and generate over $25 billion ...
(Date:8/12/2015)... MINNETONKA, Minn. , Aug. 12, 2015   ... that supports the entire spectrum of clinical research, is ... ™ , the company,s comprehensive SaaS-based eClinical technology platform, ... growth during the first two quarters of 2015.   ... and second largest quarters measured by contract value sold ...
(Date:8/12/2015)... 12, 2015  New research unveiled at Black ... phones to steal users, fingerprints. Information released today ... fingerprint scanners on mobile devices, making the security ... biometrics on mobile devices, HYPR Corp. recently released ... authentication systems with strong cryptographic security. More information ...
Breaking Biology News(10 mins):Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2MedNet Solutions Experiences Explosive Corporate Growth 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3
... An international consortium of researchers led by Universitat ... patients and studies the clinical impact of the mutations. ... the origins and world distribution of some of the ... in Europe thousands of years ago and later migrated ...
... by Innsbruck University Botanic Garden, with support from ... a practical, one-year, continual professional development (CPD) course ... countries. Its focus on inquiry-based science education (IBSE) ... that IBSE methods are more effective than current ...
... biofuels produced from crop biomass as an environmentally ... questions whether the potential climate benefit of sugarcane ... management are considered. Scientists examined the ... greenhouse gas emissions. They found that land use ...
Cached Biology News:New advances in genetic studies of Fanconi anemia patients 2Hands-on learning turns children's minds on to science 2
(Date:8/27/2015)... ... 2015 , ... Proove Biosciences, a commercial and research ... genetics and hypertension at the International Academy of Cardiology Annual Scientific ... The event, which boasts an extensive overview of the latest research developments in ...
(Date:8/26/2015)... ... August 26, 2015 , ... Lee Biosolutions, a global biotech ... manufacture of highly valued cardiac markers used in early detection of heart disease ... chemistry has led to the development and commercialization of important cardiac biomarkers used ...
(Date:8/26/2015)... August 26, 2015 Israel Proves Its Place ... 1 st place  Wayerz comes in 5 th ... Israel by venture capital fund JVP, with Chinese consulting ... China , Israel , ... Impressive achievement for the Israeli representatives in the final ...
(Date:8/26/2015)... (PRWEB) , ... August 26, 2015 , ... PRC ... to develop new business relationships with local sponsors in southern California. The Clinical Trial ... their drug development processes and regulatory pathways., , Stem ...
Breaking Biology Technology:Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 2Proove Biosciences Presents Ground-Breaking Data on Genetics and Heart Disease at 20th World Congress on Heart Disease 3Lee Biosolutions Announces Increased Investment in the Development and Manufacturing of Biomarkers Used in Early Detection Of Heart Disease 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 2Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 3Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 4Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 5Israeli Startup Takes First Place at Shengjing Global Innovation Awards 2015 6PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3
... Calif., May 12 USGI Medical, Inc. (USGI),the ... company has,licensed its incisionless surgery technology to Intuitive ... Financial terms of the deal,were not disclosed., ... development,including their intellectual property," said Gary Guthart, president ...
... N.J., May 12 Synvista Therapeutics,Inc. (Amex: ... with the,appointment of David C. Tantillo as Senior ... today, Mr. Tantillo will be responsible,for planning and ... expects commercial launch of this,product in mid- 2009., ...
... PARSIPPANY, N.J., May 12 Forest,Laboratories, Inc. ... company, and,Daiichi Sankyo, Inc. today announced that ... (amlodipine and olmesartan medoxomil),Daiichi Sankyo,s fixed-dose combination ... besylate and the angiotensin receptor,blocker olmesartan medoxomil. ...
Cached Biology Technology:USGI Medical Licenses Incisionless Surgery Technology to Intuitive Surgical 2USGI Medical Licenses Incisionless Surgery Technology to Intuitive Surgical 3Synvista Therapeutics Increases Commercial Focus by Appointing David C. Tantillo Senior Director of Marketing and Sales 2Synvista Therapeutics Increases Commercial Focus by Appointing David C. Tantillo Senior Director of Marketing and Sales 3Synvista Therapeutics Increases Commercial Focus by Appointing David C. Tantillo Senior Director of Marketing and Sales 4Forest Laboratories, Inc. and Daiichi Sankyo, Inc. Announce the Termination of the AZOR Co-Promotion Agreement 2Forest Laboratories, Inc. and Daiichi Sankyo, Inc. Announce the Termination of the AZOR Co-Promotion Agreement 3Forest Laboratories, Inc. and Daiichi Sankyo, Inc. Announce the Termination of the AZOR Co-Promotion Agreement 4
... Tissue Arrays contain 60 rabbit tissue samples arrayed ... 4 unstained slides and 1 hematoxylin and eosin ... contains 15 different tissues from 4 rabbit organisms, ... slide. Each tissue sample (or core) is 1.5 ...
... offers custom peptide synthesis with a wide variety ... fit your research needs. Purity: ... 2mg-1g Sequence Length: Up ... Fluorescein, N-acetylation, C-amidation, phosphorylation, D-amino acids, MAPs, KLH/BSA ...
... Antigen sequence: H-Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH 2 ... our corresponding peptide and ... 5 I-labelled peptide, ... (H-1470) and ([ 1 ...
... enables you to identify over 150 ... distinguish protein isoforms, protein subsets, and ... visualize peptide-protein associations and relationships easily. ... identification and relative protein expression analysis ...
Biology Products: