Navigation Links
Study: How a high-fat diet and estrogen loss leads women to store more abdominal fat than men

ine-fold increase in visceral fat compared to visceral fat developed by males on a high-fat diet. This was the final determinant that the high-fat diet triggers this cascade of events ending in visceral fat formation.

Because the human fat tissue samples the researchers analyzed also showed elevated levels of Aldh1a1 in cells extracted from tissue in obese women, "it could be that what we show about this hormone's importance to visceral obesity in mice is also true for humans," Ziouzenkova said.

"As soon as a female starts the high-fat diet consumption, a mechanism for hormonal regulation is turned on and she starts to produce retinoic acid and her metabolism becomes super thrifty. Females will store more fat than they burn," she said. "By removing the Aldh1a1 enzyme in visceral fat, we could make females release fat and burn it. We make them super-metabolically active instead."

The study identifies this enzyme as a potential sex-specific therapy for obesity, but only in very targeted ways. Deleting the enzyme genetically would be damaging because Aldh1a1 is present in all cells, meaning it has additional functions. Ziouzenkova is investigating ways to target delivery of enzyme-free cells directly to fat as a potential obesity remedy.

Contact: Ouliana Ziouzenkova
Ohio State University

Page: 1 2 3 4

Related biology news :

1. BYU study: Using a gun in bear encounters doesnt make you safer
2. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
3. Study: Exercise can lead to female orgasm, sexual pleasure
4. U of I study: Lose body weight before gaining baby weight
5. Study: Men who do load-bearing exercise in early 20s may be shielded from osteoporosis
6. USF study: Common fungicide wreaks havoc on freshwater ecosystems
7. Army study: DNA vaccine and duck eggs protect against hantavirus disease
8. Study: In-patient, out-patient stroke rehab might benefit from yoga
9. Study: Seeking Arctic methane has serious implications for Florida coastline
10. Study: Seeping Arctic methane has serious implications for Florida coastline
11. Study: No-fat, low-fat dressings dont get most nutrients out of salads
Post Your Comments:
(Date:9/28/2015)... Sept. 28, 2015 CLEAR, the ... its expedited traveler service is coming to ... travel, bringing a frictionless experience, serious speed ... "CLEAR offers our travelers an expedited ... said Jim Smith , Executive Director, ...
(Date:9/26/2015)... , Sept. 26th, 2015  Results of ... will be unveiled today at the Stanford Medicine ... Engagement Using iPad Dashboards, Connected Health Devices and ... of Pharmacy 3.0, will explain how senior patients ... data to their pharmacist via the TactioRPM remote ...
(Date:9/10/2015)... 10, 2015 Report Details The ... delivered upon previous expectations of revenues, consumer adoption and ... year in which wearables begin to achieve that mass ... the main reasons is the entrance of Apple to ... SmartWatches market, but the overall size of the wearable ...
Breaking Biology News(10 mins):
... LA JOLLA, Calif., September 25 2013 A new ... called medulloblastoma has been developed by researchers at Sanford-Burnham ... cellsthe cells that are critical for maintaining tumor growthand ... are essential for tumor progression. The process destroys the ...
... how their meat is sourced, with animal welfare ... many purchases. Unfortunately, many widely-used livestock production methods ... from the University of Cambridge has identified what ... silvopastoral systems which include shrubs and trees with ...
... , Sept. 25, 2013   GenoVive , an innovator ... against the emerging "globesity" epidemic through its development of ... on each individual,s unique metabolism.  "Weight Loss Designed by ... to customize an all natural meal and exercise program ...
Cached Biology News:
(Date:10/9/2015)... and ROCKVILLE, Md. , ... a privately-held biotechnology company developing next generation vaccines ... it has entered into an exclusive worldwide licensing ... for the treatment or prevention of any and ... the agreement, Immunomic Therapeutics will receive an upfront ...
(Date:10/9/2015)... ... October 09, 2015 , ... From blood to food ... those cells from their surroundings for research, diagnostics, and cell therapy—also known as ... this, Ann Arbor-based startup Akadeum Life Sciences is developing a radically ...
(Date:10/8/2015)... Oct. 8, 2015   Intrexon Corporation (NYSE: ... announced the appointment of Joseph L. Vaillancourt ... Nir Nimrodi who continues in his role ... Intrexon,s endeavors to generate sustainable, biologically based solutions to ... where he held a variety of key roles including, ...
(Date:10/8/2015)...  ATCC, the premier global biological materials resource and ... by The Michael J. Fox Foundation for Parkinson,s Research ... and biotechnology organizations committed to speed a cure for ... , and more than 5 million worldwide, have ... , and more than 5 million worldwide, have ...
Breaking Biology Technology:
... VICL ) today announced the enhancement of ... de Guttadauro as Vice President, Corporate,Development. Prior ... Director of,Strategy at Biogen Idec since February 2007, ... that company,s Zevalin,the first radioimmunotherapy product approved for ...
... Mulia Pangkuan Negeri -, TORONTO, Aug. 20 ... on developing simple blood-based biomarker tests for the,early ... that its co-founder and Chief Scientific Officer, Dr. ... Negeri (DMPN), a State Honour,given by the Governor ...
... Poised for Market Launch, KIRKLAND, Wash., Aug. 20 ... for the treatment of arterial,disease, today announced that it ... has started building its sales team in preparation for ... Recently Pathway moved from its old 10,000-square-foot facility ...
Cached Biology Technology: