Navigation Links
Study: How a high-fat diet and estrogen loss leads women to store more abdominal fat than men
Date:9/5/2012

COLUMBUS, Ohio A high-fat diet triggers chemical reactions in female mice that could explain why women are more likely than men to gain fat in the abdomen after eating excess saturated fat, new research suggests. The study also sheds light on why women gain fat following menopause.

Scientists identified events in female mice that start with the activation of an enzyme and end with the formation of visceral fat fat that accumulates around internal organs and is linked to a higher risk for Type 2 diabetes, heart disease and cancer.

At least one function for this enzyme is the production of a powerful hormone, which then drives up the formation of visceral fat cells. The source of this hormone is vitamin A.

This enzyme appears to be activated at higher levels in females than in males when both sexes eat a high-fat diet. When researchers genetically altered mice by deleting the enzyme, female mice stayed lean, especially in the abdominal area, even when they continued to eat a lot of fat. Males without the enzyme also developed less fat, but the effect was far less significant than in females.

The results suggest the enzyme could be a target for sex-specific anti-obesity therapy.

(See related news release at http://researchnews.osu.edu/archive/fatcapsule.htm.)

"If you asked most people what they believe causes obesity, they would probably say high food consumption and a sedentary lifestyle. But we see that there are genetic factors telling the body what to do with fat," said Ouliana Ziouzenkova, assistant professor of human nutrition at Ohio State University and senior author of the study. "A high-fat diet acts on our genetics to make us more fat or less fat. The diet is not powerful enough to do this on its own."

Further experiments showed that fat cells in female mice lacking the enzyme could produce proteins that use
'/>"/>

Contact: Ouliana Ziouzenkova
Ziouzenkova.1@osu.edu
614-292-5034
Ohio State University
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. BYU study: Using a gun in bear encounters doesnt make you safer
2. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
3. Study: Exercise can lead to female orgasm, sexual pleasure
4. U of I study: Lose body weight before gaining baby weight
5. Study: Men who do load-bearing exercise in early 20s may be shielded from osteoporosis
6. USF study: Common fungicide wreaks havoc on freshwater ecosystems
7. Army study: DNA vaccine and duck eggs protect against hantavirus disease
8. Study: In-patient, out-patient stroke rehab might benefit from yoga
9. Study: Seeking Arctic methane has serious implications for Florida coastline
10. Study: Seeping Arctic methane has serious implications for Florida coastline
11. Study: No-fat, low-fat dressings dont get most nutrients out of salads
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... how the bowel lining develops and, in the process, ... , The researchers produced evidence that stem cells are ... a feature of the bowel lining, and believe these ... controversial finding as scientists are still divided on the ... Chin Wee Tan and Professor Tony Burgess from the ...
(Date:10/15/2014)... WASHINGTON, N.Y. , Oct. 15, 2014 /PRNewswire/ ... technology solutions for home and community-based care, today ... benefits of implementing Sandata,s Santrax® Electronic Visit Verification™ ... Care Services is a home health company founded ... Texas . The ...
(Date:10/15/2014)... pneumonia in female mice to an enzyme activated by ... more resistant to respiratory infections than males. Now, an ... to bacterial pneumonia in female mice is linked to ... show that this enzyme is ultimately activated by the ... team, lead by Professor Lester Kobzik at the Harvard ...
Breaking Biology News(10 mins):Cryptic clues drive new theory of bowel cancer development 2Sandata Announces Case Study with Quality Care Services, Inc. 2
... ecological sustainability of biofuels and the impact of their ... will take place on Friday, Dec. 5, in Panama ... Forests: Trends, Implications and Emerging Alternatives, is sponsored by ... Program in Native Species Reforestation, both joint programs of ...
... "Waterproof" versions of popular varieties of rice, which can ... farmers, fields with flying colors. Several of these varieties are ... certification agencies in Bangladesh and India, where farmers suffer major ... tons of rice per year. This is enough rice to ...
... Department of Plant Biology and Biotechnology at the ... been granted the Danisco Award 2008. She received ... secondary metabolites, which are biologically active substances in, ... has focused on biosynthetic pathways, regulation and transport ...
Cached Biology News:Conference to explore sustainability of biofuels 2From genes to farmers' fields 2From genes to farmers' fields 3The Danisco Award 2008 goes to D.Sc. Barbara Ann Halkier from Faculty of Life Sciences, Copenhagen 2
(Date:10/20/2014)... 2014 Mapp Biopharmaceutical,s valiant effort to ... to fight the Ebola outbreak will make the ... production of pharmaceuticals can be, according to Kalorama ... while some may be taken aback by the ... industry knowledge are well aware of the complex ...
(Date:10/20/2014)... 20, 2014 , A major ... and the delivery of care has revealed changing trends ... inequalities in the provision of healthcare services across the ... by United European Gastroenterology (UEG), have been announced today ... awareness of the burden of GI disorders across ...
(Date:10/20/2014)... Rochelle, Virginia (PRWEB) October 20, 2014 ... of NDA Partners LLC, announced today that Ellen ... and legal support for the pharmaceutical industry, has ... and manager of its legal services practice. ... reports and expert witness and testimony, to top ...
(Date:10/19/2014)... -- NextCODE Health, which enables clinicians and researchers to use ... announced the launch of its new genomic data analysis and ... Society of Human Genetics (ASHG) annual meeting in ... apply for free beta access, visit www.nextcode.com . A ... viewed here . The Exchange: ...
Breaking Biology Technology:Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 2Kalorama: ZMapp Highlights Need For Faster Biopharmaceutical Production 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3
... and to Complete Current Phase 3 Trial of Naturlose(R) ... June 23 Spherix Incorporated (Nasdaq: SPEX ... a provider of technical and regulatory consulting services to ... it has received its first full-scale production batch of ...
... Sciences Holdings, Inc. (OTC Bulletin Board: ADLS), today announced ... once-a-day, oral antibiotic Restanza(TM) (cethromycin), showed that a 14-day ... an inhaled lethal dose of anthrax. All of the ... (the human equivalent dose of 300 mg) of Restanza ...
... VIENNA, Austria, June 23 MIG ... Venture Capital & Private Equity Award,competition, hosted by the industry ... between the,German venture fund and the Austrian biotechnology company as ... Biologicals. , Last Tuesday MIG Fonds ...
Cached Biology Technology:Spherix Announces Full-Scale Production of Pharmaceutical Tagatose 2Spherix Announces Full-Scale Production of Pharmaceutical Tagatose 3Spherix Announces Full-Scale Production of Pharmaceutical Tagatose 4Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study 2Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study 3AFFiRiS AG: 1st Place in Venture Capital & Private Equity Awards for MIG Fonds and AFFiRiS 2AFFiRiS AG: 1st Place in Venture Capital & Private Equity Awards for MIG Fonds and AFFiRiS 3
Request Info...
Request Info...
... Art GLP facility with capabilities from ... fermentation. Coordinated process development from ... operation capable of simultaneous production runs ... Hosts include: Bacteria, Yeast, Fungi, ...
ExonBio Service provides one-stop recobinant protein shopping from cloning, expression and purification. Price including gene cloning....
Biology Products: