Navigation Links
Study: Fountain of youth for your heart?
Date:11/2/2007

An age-related decline in heart function is a risk factor for heart disease in the elderly. While many factors contribute to a progressive age-related decline in heart function, alterations in the types of fuels the heart uses to produce energy also play important roles. Jason Dyck and his research team at the University of Alberta have been studying the types of fuels used by the heart in young and aged mice. The young healthy heart normally used a balance of fat and sugar to generate energy to allow the heart to beat and pump blood efficiently. However, as the heart ages the ability to use fat as an energy source deteriorates. This compromises heart function in the elderly. Interestingly, at a time when the heart is using less fat for energy, Dyck has shown that a protein that is responsible for transporting fat into the contractile cells of the heart actually increases. Based on this finding, Dyck proposed that the mismatch between fat uptake and fat use in the heart could lead to an accumulation of fat in the heart resulting in an age-related decrease in heart function.

Using a genetically engineered mouse that is deficient in a protein that is responsible for transporting fat into the cells of the heart, Dyck studied these mice as they aged. These genetically altered mice have no choice but to mainly use sugar as a fuel source because they lack the protein that allows them to use fat as a primary fuel source. In an exciting new finding, Dyck showed that old genetically modified mice did not accumulate fat in their hearts, as did ordinary mice. In addition, Dyck and his team showed that these old genetically altered mice out-performed ordinary old mice on a treadmill test, were completely protected from age-related decline in heart function, and in many ways their hearts looked and performed like hearts from a young mouse. His findings suggest that the protein responsible for transporting fat into the contractile cells of the heart may be a candidate for drug inhibition and that this drug could protect the heart from aging.

This research holds great promise for human beings. Dyck hopes it will lead to the development of medications that inhibit the uptake of fatty acids into the heart and prevent and/or reverse the effects of aging on the heart muscle.


'/>"/>
Contact: Kris Connor
kris.connor@ualberta.ca
University of Alberta
Source:Eurekalert

Related biology news :

1. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
2. Study: homemade gene expression technology unreliable
3. New study: Sexually transmitted disease treatment can be effectively administered by sex partners
4. Study: Well-known protein helps stem cells become secretory cells
5. Study: Harmless virus kills some cancers
6. Study: Predatory dinosaurs had bird-like pulmonary system
7. Study: Plants use dual defense system to fight pathogens
8. Mouse study: New muscle-building agent beats all previous ones
9. Study: Competition for sex is a jungle out there
10. Study: Paramedics save more lives when they dont follow the rules
11. NASA study: Alaskan fires affected Houston air quality in 2004
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... BETHESDA, Md. , June 22, 2016  The American ... by Trade Show Executive Magazine as one of ... Summit on May 25-27 at the Bellagio in ... based on the highest percentage of growth in each of ... number of exhibiting companies and number of attendees. The 2015 ...
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016  The Prostate Cancer Foundation ... increasingly precise treatments and faster cures for prostate cancer. Members of the Class ... across 15 countries. Read More About the Class of ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is ... projects are designed, built and brought to market. , The Design Lab is ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the ... the Dow Jones Industrial Average edged 0.27% lower to finish ... 0.17%. Stock-Callers.com has initiated coverage on the following equities: Infinity ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... ). Learn more about these stocks by accessing their free ...
Breaking Biology Technology: