Navigation Links
Study: Fountain of youth for your heart?
Date:11/2/2007

An age-related decline in heart function is a risk factor for heart disease in the elderly. While many factors contribute to a progressive age-related decline in heart function, alterations in the types of fuels the heart uses to produce energy also play important roles. Jason Dyck and his research team at the University of Alberta have been studying the types of fuels used by the heart in young and aged mice. The young healthy heart normally used a balance of fat and sugar to generate energy to allow the heart to beat and pump blood efficiently. However, as the heart ages the ability to use fat as an energy source deteriorates. This compromises heart function in the elderly. Interestingly, at a time when the heart is using less fat for energy, Dyck has shown that a protein that is responsible for transporting fat into the contractile cells of the heart actually increases. Based on this finding, Dyck proposed that the mismatch between fat uptake and fat use in the heart could lead to an accumulation of fat in the heart resulting in an age-related decrease in heart function.

Using a genetically engineered mouse that is deficient in a protein that is responsible for transporting fat into the cells of the heart, Dyck studied these mice as they aged. These genetically altered mice have no choice but to mainly use sugar as a fuel source because they lack the protein that allows them to use fat as a primary fuel source. In an exciting new finding, Dyck showed that old genetically modified mice did not accumulate fat in their hearts, as did ordinary mice. In addition, Dyck and his team showed that these old genetically altered mice out-performed ordinary old mice on a treadmill test, were completely protected from age-related decline in heart function, and in many ways their hearts looked and performed like hearts from a young mouse. His findings suggest that the protein responsible for transporting fat into the contractile cells of the heart may be a candidate for drug inhibition and that this drug could protect the heart from aging.

This research holds great promise for human beings. Dyck hopes it will lead to the development of medications that inhibit the uptake of fatty acids into the heart and prevent and/or reverse the effects of aging on the heart muscle.


'/>"/>
Contact: Kris Connor
kris.connor@ualberta.ca
University of Alberta
Source:Eurekalert

Related biology news :

1. Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses
2. Study: homemade gene expression technology unreliable
3. New study: Sexually transmitted disease treatment can be effectively administered by sex partners
4. Study: Well-known protein helps stem cells become secretory cells
5. Study: Harmless virus kills some cancers
6. Study: Predatory dinosaurs had bird-like pulmonary system
7. Study: Plants use dual defense system to fight pathogens
8. Mouse study: New muscle-building agent beats all previous ones
9. Study: Competition for sex is a jungle out there
10. Study: Paramedics save more lives when they dont follow the rules
11. NASA study: Alaskan fires affected Houston air quality in 2004
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/14/2017)... IBM ) is introducing several innovative partner startups at VivaTech ... startups and global businesses, taking place in Paris ... will showcase the solutions they have built with IBM Watson ... France is one of the most dynamic ... in the number of startups created between 2012 and 2015*, ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:5/6/2017)... SINGAPORE , May 5, 2017 ... has just announced a new breakthrough in biometric ... that exploits quantum mechanical properties to perform ... new smart semiconductor material created by Ram Group ... across finance, entertainment, transportation, supply chains and security. ...
Breaking Biology News(10 mins):
(Date:7/27/2017)... ... July 27, 2017 , ... Margot Connor, ... position on Baltimore Business Journal’s 2017 Tech 10 List of “outstanding professionals in ... peers for contributions to the technology industry within their local community. Honorees are ...
(Date:7/26/2017)... ... July 26, 2017 , ... Franz Inc ., an ... technology for Knowledge Graphs, today announced Gruff v7.0 , the industry’s leading ... users and graph experts the ability to visually build queries and explore connections ...
(Date:7/26/2017)... ... July 25, 2017 , ... The leading Regenerative Veterinary Medicine ... cell therapy has been used on more than 13,000 animals. VetStem was ... fatal injuries to tendons and ligaments. , In 2003 VetStem signed a worldwide ...
(Date:7/26/2017)... , ... July 26, 2017 , ... ... Research Program at the National Institutes of Health (NIH), will be one of ... annual conference provides a platform for a multi-stakeholder discussion on the latest advancements ...
Breaking Biology Technology: