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Study: Fluid buildup in lungs is part of the damage done by the flu
Date:2/10/2009

"If the bacteria or virus wins, you get more and more fluid and you get sicker and sicker. But if you can wash it away, then you've won and things go back to normal."

The potential therapy that Davis is investigating was originally used in earlier research to block the generation of these nucleotides to prove the fluid clearance mechanism behind a different viral lung disease. Now that his newer work has shown that influenza A has the same effect on the lungs, Davis is planning to test the therapy's effects against flu infection.

The first studies will involve delivering the drug in aerosol form to mice. Davis also plans to culture human epithelial cells to see whether these cells in humans have the same role as do mouse cells in the fluid clearance mechanism.

Davis noted that the current health-care system can help manage most serious cases of the flu, even if some of the sicker patients require ventilation to help them clear fluid and get oxygen to the blood.

"But if we get into a pandemic situation and there are 200 people with low levels of oxygen in their blood and five ventilators, 195 people are out of luck. We hope to develop something that those people can take by aerosol that might reduce the need for that kind of ventilation," he said.


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Contact: Ian Davis
Davis.2448@osu.edu
614-292-2954
Ohio State University
Source:Eurekalert

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