COLUMBUS, Ohio In a fight against respiratory infections, the body typically produces a little fluid to help the lungs generate a productive cough. But new research suggests that the influenza virus can tip the balance toward too much fluid in the lungs, interfering with the supply of oxygen to the rest of the body.
An immune response ultimately is needed to eliminate the virus, but this research suggests that it's not the presence of the virus alone that does all the harm to a sick person. Instead, the fluid buildup deep inside the lungs might help kill a person infected with the flu, according to the research, which was conducted in mice.
"My take is that when people die of these illnesses, they're dying because they can't breathe," said Ian Davis, assistant professor of veterinary biosciences at Ohio State University and senior author of the study. "If the lungs aren't working well, then it doesn't matter whether a week from now you can make an immune response and clear the virus if you can't survive that long because you just can't get oxygen."
Detailing exactly how flu interferes with fluid clearance in the lungs lays the groundwork for a second phase of related studies to test a new therapy a drug that is already known to regulate the amount of fluid that builds up in infected lungs.
In the event of a flu pandemic, such a drug, which scientists hope could be inhaled by mouth, might be an important supplement to antiviral medications and ventilators, Davis said.
The research is published in a recent issue of the American Journal of Respiratory and Critical Care Medicine.
Davis and colleagues infected mice with high doses of an influenza A virus to compare oxygen levels and fluid clearance in infected mice to those of healthy mice.
Mice that were infected with the highest doses of flu experienced a steady decline in oxygen in their blood and higher levels of fluid in the lungs. Two day
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Ohio State University