Navigation Links
Study: Fluid buildup in lungs is part of the damage done by the flu
Date:2/10/2009

COLUMBUS, Ohio In a fight against respiratory infections, the body typically produces a little fluid to help the lungs generate a productive cough. But new research suggests that the influenza virus can tip the balance toward too much fluid in the lungs, interfering with the supply of oxygen to the rest of the body.

An immune response ultimately is needed to eliminate the virus, but this research suggests that it's not the presence of the virus alone that does all the harm to a sick person. Instead, the fluid buildup deep inside the lungs might help kill a person infected with the flu, according to the research, which was conducted in mice.

"My take is that when people die of these illnesses, they're dying because they can't breathe," said Ian Davis, assistant professor of veterinary biosciences at Ohio State University and senior author of the study. "If the lungs aren't working well, then it doesn't matter whether a week from now you can make an immune response and clear the virus if you can't survive that long because you just can't get oxygen."

Detailing exactly how flu interferes with fluid clearance in the lungs lays the groundwork for a second phase of related studies to test a new therapy a drug that is already known to regulate the amount of fluid that builds up in infected lungs.

In the event of a flu pandemic, such a drug, which scientists hope could be inhaled by mouth, might be an important supplement to antiviral medications and ventilators, Davis said.

The research is published in a recent issue of the American Journal of Respiratory and Critical Care Medicine.

Davis and colleagues infected mice with high doses of an influenza A virus to compare oxygen levels and fluid clearance in infected mice to those of healthy mice.

Mice that were infected with the highest doses of flu experienced a steady decline in oxygen in their blood and higher levels of fluid in the lungs. Two day
'/>"/>

Contact: Ian Davis
Davis.2448@osu.edu
614-292-2954
Ohio State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UNC study: Tinkering with the circadian clock can suppress cancer growth
2. Study: Excessive use of antiviral drugs could aid deadly flu
3. Study: Did early climate impact divert a new glacial age?
4. UNC study: Text messaging may help children fight off obesity
5. Study: Elderly Women can increase strength but still risk falls
6. Study: Wildlife need more complex travel plans
7. Study: Tropical wetlands hold more carbon than temperate marshes
8. Study: Bird diversity lessens human exposure to West Nile Virus
9. Study: urban black bears live fast, die young
10. Study: Typhoons bury tons of carbon in the oceans
11. Study: Migrant laborers valuable to horticulture industry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... news release is available in German . ... chemical signals between organisms is considered the oldest form ... interactions between conspecifics, for example, the sexual attraction between ... social responses and to coordinate reproductive behavior in males ... the University of the Algarve in Faro, Portugal, and ...
(Date:8/29/2014)... of the Tibetan plateau -- the largest topographic anomaly ... both its profound effect on climate and its reflection ... GSA Bulletin , Katharine Huntington and colleagues employ a ... modern and fossil snail shells to investigate the uplift ... , Views range widely on the timing of surface ...
(Date:8/28/2014)... new study reports that an expansion of marine protected ... key ecological functions. According to investigators from the ... protecting fish have focused on saving the largest numbers ... that provide key and difficult-to-replace ecological functions. ... performed by fish species that also are food for ...
Breaking Biology News(10 mins):Ready for mating at the right time 2Ready for mating at the right time 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... 2010) Today, the Association for Molecular Pathology (AMP) ... Genetics, Health and Society (SACHGS) meeting focused on whole ... and its incorporation into clinical practice, AMP raised ethical ... "In the next five years, the application of ...
... 2010) -- Atmospheric research often focuses on clouds, impact on weather ... with a base some 6,000 feet above earth. University of ... other end of the air column closer to homethe bottom of ... boundary layer. A report on his team,s work appears in a ...
... in the atmosphere rise, policy makers and scientists are ... with the greenhouse gas. One method ... otherwise known as carbon sequestration. CCS, a newly developing ... from the Earth,s atmosphere. Donald J. ...
Cached Biology News:AMP commends SACGHS whole genome sequencing focus, raises ethical questions and forms working group 2AMP commends SACGHS whole genome sequencing focus, raises ethical questions and forms working group 3
(Date:8/28/2014)... “This kit has an improved extraction efficiency and provides users ... said Mark Tess, PhD, Mycotoxin Product Manager for Charm Sciences. ... USDA-GIPSA inspection agencies that have a need to detect aflatoxin ... a matter of minutes with nothing but our equipment and ... grain before accepting it, but they no longer have to ...
(Date:8/28/2014)... , Aug. 28, 2014  Next month, executives from clinical ... key industry events beginning with Patient-Centered Clinical Trials 2014 ... Boston , September 4-5. Patient recruitment experts ... Aaron Fleishman will share insights on the benefits ... variety of tactics – from media to mobile apps – ...
(Date:8/28/2014)... 2014 Scientists, researchers, and technologists will ... Laser Damage 2014 symposium. Marking its 46th year, ... will run 14-17 September. The event is sponsored by ... . , The premier conference for basic and applied ... optical materials will engage researchers and engineers from numerous ...
(Date:8/28/2014)... New York, NY (PRWEB) August 28, 2014 ... has renewed its long term partnership with PTI ... to provide clients with state of the art leak ... state of the art instruments currently available. As part ... a new High Voltage Leak Detection Instrument ...
Breaking Biology Technology:BBK Worldwide Leads Sessions at Key September Events 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3
... 14 Neurocrine Biosciences,Inc. (Nasdaq: NBIX ) announced ... been appointed President and Chief Executive,Officer and a member ... will step down as President and Chief Executive Officer ... of the Board of,Directors., "While this was a ...
... Industry Ltd. (Nasdaq: SHMR ) ("Shamir"), a ... progressive ophthalmic lens,market, announced today that its board ... aggregate amount of US$ 4.0 million (approximately NIS,15.1 ... rate of,exchange), or approximately US$ 0.243 (approximately NIS ...
... ... Meet Growing Global Demand, WILMINGTON, Del., Jan. ... Fanandakis group vice president - DuPont Applied,BioSciences. In this newly ... a range of bio-based,products and technologies to meet growing global ...
Cached Biology Technology:Neurocrine Announces Appointment of Kevin Gorman, Ph.D., as President and Chief Executive Officer 2Shamir Optical Industry Ltd. Announces Declaration of a Cash Dividend 2Shamir Optical Industry Ltd. Announces Declaration of a Cash Dividend 3DuPont Names Nicholas Fanandakis as Group Vice President - DuPont Applied BioSciences 2
... Model 1575 immunowash microplate washer 100-240 V, ... have flat-, U-, or V-bottom wells. The ... and vertical needle positions to an accuracy ... aspiration, and overflow washing. It can store ...
... MULTI-FUN Incubator is a compact benchtop ... a microprocessor controller with a large ... and agitation speed. Air circulation inside ... incubator. Temperature can be easily calibrated ...
... is a compact benchtop and stackable ... controller with a large display screen ... speed. Air circulation inside to evenly ... can be easily calibrated from the ...
... siRNA --- a cocktail of 3 siRNAs ... interestis our most popular product. The siTrio ... knockdown of your target gene when used ... transfection and confirmation of optimal transfection with ...
Biology Products: