Navigation Links
Study: Darwin was right to worry that marriage to his cousin affected his offspring
Date:5/3/2010

a, published a genetics study detailing how inbreeding led to the extinction of the Spanish Habsburg dynasty. The group then teamed to conduct a similar analysis of the effects of the Darwin-Wedgwood connections.

The researchers traced 25 families among four generations of the Darwin-Wedgwood dynasty, which included a number of consanguineous marriages. The families had 176 children, 21 of whom died before age 10.

They then entered the data into a computer program that documented gene flow across the generations and calculated the inbreeding coefficient for these families. The resulting number represents the probability that within one's genetic code, an individual receives two genes identical by descent as a result of the common ancestry of his or her parents.

Darwin's children had an inbreeding coefficient of 0.0630, meaning that there is a 6.3 percent chance that identical copies of a given gene will come from each parent. This figure is nearly identical to the already-known 6.25 percent chance that offspring of first-cousin marriages will experience the same genetic effect.

That means if both the mother and father have a deleterious allele an allele is an alternate expression of a gene there is a 6 percent chance that offspring will receive both of those deleterious alleles and the related damaging effects will occur. Statistically, this translates into a roughly 2 percent chance that the children of first cousins will develop a congenital defect, Berra noted roughly the same order of difference in risks between a 30-year-old woman and a 41-year-old woman giving birth.

Darwin was concerned that his own ill health had been inherited by his children, though that was unlikely because he probably suffered from a parasitic disease rather than a genetic defect, Berra noted.

Instead, Berra and his colleagues suggest that Darwin's offspring might have had a higher chance of succumbing to such illnesses as TB an
'/>"/>

Contact: Tim Berra
berra.1@osu.edu
419-755-4310
Ohio State University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Study: diabetic neuropathy costs billions per year in lost work time
2. Study: Fountain of youth for your heart?
3. First-ever study: lack of critical lubricant causes wear in joints
4. Mayo Clinic study: Ossurs collars superior in immobilization and reduction of pressure
5. Study: weight-loss tips differ in African-American, mainstream magazines
6. Smithsonian study: Sediment prediction tools off the mark
7. Mouse study: When it comes to living longer, its better to go hungry than go running
8. Geisinger study: Inflammatory disease causes blindness
9. Stanford study: Bioenergy potential of reviving abandoned agricultural land
10. U-M study: Herceptin targets breast cancer stem cells
11. Study: Future snowmelt in West twice as early as expected; threatens ecosystems and water reserves
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study: Darwin was right to worry that marriage to his cousin affected his offspring
(Date:10/14/2014)... years since T. rex took its last ... is breathing life back into dinosaurs using high-powered computer ... has important implications for how dinosaurs used their noses ... of smell and cool their brains. , "Dinosaurs ... Jason Bourke, lead author of the new study published ...
(Date:10/14/2014)... of the planet,s leading questions is how to produce ... variable climate. The Food and Agriculture Organization of the ... over the next 40 years to feed a growing ... the necessary rise in food production. Plants—grains, cereals, ... supporting livestock. Current research must tap into our ...
(Date:10/14/2014)... fish oil supplements, rich in omega-3 fatty acids, do not ... which the heart can beat as fast as 150 beats ... the Montreal Heart Institute were published in the Journal ... , For the trial, 337 patients with atrial fibrillation not ... of fish oil a day or to placebo for up ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Building a bridge from basic botany to applied agriculture 2Building a bridge from basic botany to applied agriculture 3
... Tiny seawater algae could hold the key to crops ... to changing climates. Researchers at the University of Edinburgh ... for when its main food source is in short supply. ... can survive when nutrients are scarce and to grow high-yield ...
... there is broad agreement that U.S. schools have a ... technology, engineering and math (STEM) among students from kindergarten ... only essential to many current and future careers; it ... participate in an increasingly complex world--from understanding the challenges ...
... photocopier and fidgeting at your desk are contributing ... think. Researchers have found that both the ... are associated with cardiorespiratory fitness. The intensity of ... a cumulative 30-minute increase in moderate physical activity ...
Cached Biology News:New report offers roadmap for success in K-12 STEM education 2Fidgeting your way to fitness 2
(Date:10/20/2014)... 20, 2014 , A major ... and the delivery of care has revealed changing trends ... inequalities in the provision of healthcare services across the ... by United European Gastroenterology (UEG), have been announced today ... awareness of the burden of GI disorders across ...
(Date:10/20/2014)... Earle Martin , Chief Executive ... Ellen Teplitzky, an experienced attorney specializing in business ... has joined the firm as Director of Legal ... NDA Partners provides legal services, including research, ... top law firms and their clients in cases ...
(Date:10/19/2014)... NextCODE Health, which enables clinicians and researchers to ... today announced the launch of its new genomic data analysis ... American Society of Human Genetics (ASHG) annual meeting in ... and apply for free beta access, visit www.nextcode.com . ... be viewed here . The Exchange: ...
(Date:10/19/2014)... The report "Chocolate, Cocoa Beans, Lecithin, Sugar and ... and Forecast (2011 - 2016)," analyzes the chocolate ... the major market drivers, restraints, and opportunities for the ... The global chocolate market is expected to grow from ... an estimated CAGR of 2.7% from 2011 to 2016. ...
Breaking Biology Technology:Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 2Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 3Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 4Major Survey Reveals Changing Trends and Inequalities in Healthcare Provision for Gastrointestinal Disorders Across Europe 5NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 2The NextCODE Exchange: The first global, real-time system for sharing full-resolution genomic data 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 2Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 3Chocolate Market Projected To Reach $98.3 Billion by 2016 - New Report by MarketsandMarkets 4
... , BOTHELL, Wash., ... a leading developer, manufacturer, and marketer of proprietary cGMP hypothermic ... today announced that it has been granted a Japanese patent ... from injury and death caused by cold temperatures used in ...
... ... Netech Corporation, innovative leader in the manufacture of precision ... Infusion Pump Analyzer, IPA 2000. Utilizing Netech’s patent pending technology; accurate ... be measured faster than ever before. IPA 2000 is compact and ...
... and politicians, and has been recounted everywhere from tourist guidebooks ... chemical weapons on Iraqis just after World War I. ... the historical record, says R. M. Douglas, a historian at ... issue of The Journal of Modern History , no ...
Cached Biology Technology:BioLife Solutions Granted Japanese Biopreservation Patent 2BioLife Solutions Granted Japanese Biopreservation Patent 3Netech Corporation Announces the Release of IPA 2000 -- Infusion Pump Analyzer for Fast and Accurate Testing of All Infusion Pumps 2Despite claims, UK did not gas Iraqis in the 1920s, new research finds 2Despite claims, UK did not gas Iraqis in the 1920s, new research finds 3Despite claims, UK did not gas Iraqis in the 1920s, new research finds 4
... The Sub-Cell Model 96 and PowerPac basic power ... of nucleic acids in agarose gels. This Model ... x 10 cm UV-transparent gel tray with fluorescent ... power supply, 100-120 and 220-240 V, provides output ...
... The mini ReadySub-Cell GT cell and PowerPac ... gel electrophoresis of nucleic acids in agarose gels. ... lid with cables and electrodes, and leveling bubble. ... V, provides output of 10-300 V, 4-400 mA, ...
... cell and PowerPac basic power supply are used ... in agarose gels. The wide mini format cell ... electrodes, and leveling bubble. The PowerPac basic power ... 10-300 V, 4-400 mA, and 75 W. Power ...
... The Sequi-Gen GT and PowerPac 3000 system, 220-240 ... a 38 x 30 cm vertical slab gel ... electrophoresis cell, which is capable of separating nucleic ... integral plate chamber (IPC) assembly (IPC and bonded ...
Biology Products: