Navigation Links
Study: Antibiotics are unique assassins
Date:3/11/2013

n the gaseous environment, the two treatments were identical. There was no difference in cell death between the two populations.

Before performing these experiments, Lewis' team first looked at signals of a fluorescent dye, which previous researchers had used as an indicator for ROS levels. The team treated bacterial cells with a variety of antibiotics and measured the strength of this signal. Since antibiotics were presumed to increase ROS levels, one would have expected increased concentrations of antibiotics to correlate with stronger signals. However, Lewis' group saw no such correlation.

"But there's a difference between correlation and direct observation," Keren said. In order to support their observations with unequivocal data, the team members physically separated the cells that had stronger fluorescent signals from those with weak signals and treated them both with the same antibiotics. Both populations suffered equivalent cell death.

"The research from Dr. Lewis' group demonstrates that, contrary to current dogma, antibiotics apparently do not kill bacteria through induction of reactive oxygen species," said Steven Projan, vice president for research and development at iMed and head of Infectious Diseases and Vaccines at MedImmune, both subsidiaries of AstraZeneca. "The results shown are rather clear but still leave us with the mystery as to how antibacterial drugs help infected people clear bacterial infections. At this point, we should probably dispense with the 'one size fits all' approach to bacterial killing by antibiotics," said Projan, who was not involved in the research.

With these results, Lewis and Keren hope the field will be able to focus its efforts on understanding the true mechanisms of how antibiotics wipe out bacteria in order to effectively address chronic bacterial infections, one of the most pressing issues facing public health today.


'/>"/>

Contact: Lori Lennon
l.lennon@neu.edu
617-680-5129
Northeastern University College of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. BYU study: Using a gun in bear encounters doesnt make you safer
2. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
3. Study: Exercise can lead to female orgasm, sexual pleasure
4. U of I study: Lose body weight before gaining baby weight
5. Study: Men who do load-bearing exercise in early 20s may be shielded from osteoporosis
6. USF study: Common fungicide wreaks havoc on freshwater ecosystems
7. Army study: DNA vaccine and duck eggs protect against hantavirus disease
8. Study: In-patient, out-patient stroke rehab might benefit from yoga
9. Study: Seeking Arctic methane has serious implications for Florida coastline
10. Study: Seeping Arctic methane has serious implications for Florida coastline
11. Study: No-fat, low-fat dressings dont get most nutrients out of salads
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2015)... 13, 2015 According to ... Biometrics Market Forecast & Opportunities, 2020", the global biometrics ... around 14% till 2020. The biometrics market is ... implementation and review of biometric management systems. The ... products with greater efficiency, are resulting in increasing ...
(Date:4/10/2015)... , April 10, 2015 ... addition of the "Security Competitive Profiles - NEC" ... http://photos.prnewswire.com/prnh/20130307/600769) , NEC will continue to supply ... to the market, with a company focus on the ... anticipated. Winning opportunities in the ...
(Date:4/8/2015)... April 8, 2015  Infinisource, a leading provider ... and Morpho, a leading supplier of biometric identification ... the market,s most advanced biometrically-enabled time clock, the ... time clock is setting a bold, new standard ... for the small and mid-size employer. When connected ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3
... WEST LAFAYETTE, Ind. - Bacteria are able to build camouflaged ... by manipulating a natural cellular process. , ... a pair of proteins from the bacteria Legionella pneumophila , ... divert raw materials within the cell for use in building and ...
... from LIFE the Faculty of Life Sciences at the ... different growth pattern than non-breastfed children. Breastfeeding lowers the levels ... which means that growth is slightly slower. This is believed ... life. The PhD project is part of SKOT, ...
... camera trap video footage from the forests of Thailand ... country are paying off, according to the Wildlife Conservation ... several locations across Thailand,s Western Forest Complex over the ... the lives of tigers, Asian elephants, gaurs, sun bears, ...
Cached Biology News:Purdue scientists reveal how bacteria build homes inside healthy cells 2Purdue scientists reveal how bacteria build homes inside healthy cells 3Breastfeeding promotes healthy growth 2Candid video clips from Thailand show anti-poaching efforts saving wildlife 2
(Date:4/24/2015)... PAREXEL International Corporation (NASDAQ: PRXL ), ... Partnerships in Clinical Trials named PAREXEL,s Drew Garty ... of the Year.  The honor recognizes Mr. Garty,s leadership ... MyTrials ® Data-Driven Monitoring solution. ... Partnership Awards in Boston , Mr. ...
(Date:4/23/2015)... 2015 The Thomas Brain Health ... a groundbreaking pilot study to see if early ... as little as three to six months. , ... nutritional medicine—will aggressively target and simultaneously treat the ... aging brain. These include oxidative stress, neuroinflammation, mitochondrial ...
(Date:4/23/2015)...  Neurocrine Biosciences, Inc. (Nasdaq: NBIX ) announced ... 2015 results before the Nasdaq market opens on Thursday, ... call and webcast to discuss its financial results and ... at 8:00 a.m. Eastern Time (5:00 a.m. Pacific Time). ... by dialing 866-952-1906 (US) or 785-424-1825 (International) using the ...
(Date:4/23/2015)... 2015  Veracyte, Inc. (NASDAQ: VCYT ) today ... to sell approximately $40 million of its common stock ... will purchase an aggregate of 4,907,975 shares of common ... the closing stock price on April 22, 2015. The ... including Broadfin Capital, Camber Capital, Deerfield, Longwood Capital Partners ...
Breaking Biology Technology:PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Veracyte, Inc. Announces $40 Million Private Placement 2Veracyte, Inc. Announces $40 Million Private Placement 3Veracyte, Inc. Announces $40 Million Private Placement 4
... DIEGO, Feb. 6 SGX Pharmaceuticals, Inc.,(Nasdaq: SGXP ) announced ... The conference information is as follows:, -- 10th Annual ... at 1:15 PM Eastern Standard Time at the Waldorf=Astoria, ... Conference: Tuesday, February 19, 2008 at 11:30 ...
... 5 BioSpecifics,Technologies Corp. (OTC Bulletin Board: BSTC) announced ... owed to it by its former CEO, Edwin H.,Wegman, ... Edwin H. Wegman,repaid the loan amount plus accrued interest ... of BioSpecifics, common stock to certain private,investors. The Estate ...
... Facility Services(R), LLC and,its family of companies ... the largest independent clinical technology maintenance and,management ... acquisition,is part of an aggressive growth strategy ... and accelerate the expansion of its,geographic footprint., ...
Cached Biology Technology:Linc Facility Services Acquires Morse Medical 2
Full-length cDNA clone CS0DJ013YG01 of T cells (Jurkat cell line) of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86SZ3] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
...
...
All-in-one mix, removes primers and dNTPs from PCR product for following direct sequencing...
Biology Products: