Navigation Links
Studies point to novel target for treating arrhythmias
Date:1/21/2009

Abnormal heart rhythms arrhythmias are killers. They strike without warning, causing sudden cardiac death, which accounts for about 10 percent of all deaths in the United States.

Vanderbilt investigators have discovered a new molecular mechanism associated with arrhythmias. Their findings, reported in The Journal of Clinical Investigation, could lead to novel arrhythmia treatments.

"The current antiarrhythmic drugs do not prolong life," said Bjrn Knollmann, M.D., Ph.D., associate professor of Medicine and Pharmacology and the senior author of the current report. "There's a large need for new approaches to antiarrhythmic therapy."

In their quest to understand how irregular heart rhythms arise as a way to find new molecular targets for treatment Knollmann and his colleagues have focused on the role of calcium inside heart muscle cells.

Calcium is central to the contractile cycle. After it is released from its storage sites in heart muscle cells, it interacts with proteins called troponins, part of the cell's myofilament contractile apparatus. The interaction of calcium with troponins regulates myofilament activation and contraction.

Mutations in troponin genes had been linked to inherited forms of hypertrophic cardiomyopathy (HCM), which carries a high risk of sudden cardiac death. HCM is perhaps most famous as a cause of sudden cardiac death in young athletes, but it can affect individuals of any age.

In previous studies, Knollmann's team demonstrated that troponin mutations associated with HCM increase the sensitivity of the troponins to calcium they bind calcium more readily, which activates the myofilaments more easily and results in stronger contractions.

Increased myofilament calcium sensitivity has also been found in acquired heart diseases, such as heart failure, that have a high incidence of sudden cardiac death, Knollmann said. He and his colleagues proposed that increased myofilament calcium sensitivity contribut
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Studies examine genetic determinants of ADHD
2. Studies offer guide as protein interaction mapping comes of age
3. Web-based case studies help students develop career skills
4. To improve forecasting earthquakes, NJIT mathematician studies grains
5. Studies on imaging and tracking transplanted cells
6. UI researchers help to improve carbon measurements in global climate studies
7. MSU researcher studies ties between cholesterol drugs, muscle problems
8. Studies of small water fleas help ecologists understand population dynamics
9. ASU researchers receive NIH awards for studies of malaria and emergent disease
10. Drug-embedded microparticles bolster heart function in animal studies
11. NIAID funds studies of how SARS and bird flu evade antiviral responses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... spreading rapidly and to an unexpected extent. The outbreak ... and the virus shows a new disease dynamic in ... this reason, the German National Academy of Sciences Leopoldina, ... and the Union of the German Academies of Sciences ... epidemic today. , In the statement the academies call ...
(Date:10/15/2014)... VILNIUS, Lithuania , Oct. 15, 2014 /PRNewswire/ ... identification technologies, today announced the availability of the ... . VeriLook Surveillance 3.0 provides real-time biometric face ... multiple high-resolution digital surveillance cameras. The new version ... detects and differentiates people from objects while they ...
(Date:10/14/2014)... house fly genome for the first time, revealing robust ... that thrives in pathogen-rich dung piles and garbage heaps. ... Genome Biology , will increase understanding of house ... adapt to resist insecticides, which could lead to novel ... and transmit more than 100 human and animal diseases, ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 2VeriLook Surveillance 3.0 SDK Identifies Faces and Moving Objects, Differentiates Pedestrians from Other Moving Objects in Video Surveillance Systems 3House fly genome reveals expanded immune system 2
... commonly cultivated cacao plant in the world is revealed ... Researchers have utilised high quality DNA sequences to demonstrate the ... can lead to higher yielding cocoa plants that still produce better ... cacao tree ( Theobroma cacao L. ), but ...
... Plymouth University, and the Universidad Federal da Bahia in ... diversity and density of coral colonies off the coast ... El Nio event of 1997-98, creating an opportunity for ... major environmental incident of this nature can have on ...
... ecology has centered on the role of microbes in ... print in the journal Applied and Environmental Microbiology ... Australia, and collaborators show how changes in the populations ... at ecosystem levels. "Ecological theories developed for ...
Cached Biology News:Genome hints at markers for higher-producing, better-tasting chocolate 2Catastrophic climatic events leave corals facing a decade-long fight for recovery 2
(Date:10/22/2014)... 2014 Shimadzu Scientific Instruments introduces its ... for the pain management and clinical markets. The software ... review by allowing users to highlight and review results ... QuantAnalytics allows analysts to filter results by group or ... by eliminating the need to sift through analytes of ...
(Date:10/22/2014)... Cranford, NJ (PRWEB) October 22, 2014 ... technologies and services – has been working with a ... Health and New Haven Farms Community Farming Collaborative to ... iPad-based ePRO solution. The study, which started in ... Wellness program that provides participants weekly exposure to and ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Grace Century, ... and healthcare projects, announces the addition of Dr. ... to its advisory team. Dr. Siddiqui will provide further ... , A graduate of University College Medical School ... degreed in medicine in 2001. With further certification as ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 According ... Market by Service Type (Consulting, Integration, Deployment & ... by Deployment Model (Public, Private, Others (Hybrid & ... MarketsandMarkets, defines and segments the Cloud Professional Services ... and forecasting of revenues. It also identifies the ...
Breaking Biology Technology:Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5
... Today, the rights to Verus,Pharmaceuticals, pediatric asthma ... for aerosol delivery were acquired by,AstraZeneca. Following ... 2006, this is the second major pharmaceutical ... in the development pipeline. Included in ...
... Sciences Company,s Leadership Team, INDIANAPOLIS, Sept. 24 ... short-term and long-term biomaterials storage,sample management and cold ... sciences leader, joins the company as vice president ... created position, Ball is responsible for the company,s,worldwide ...
... into Sample Analysis Systems-, PHILADELPHIA, Sept. ... nanoscale whole genome imaging and analytic,platforms for ... announced the issuance of a patent for ... analyzer. The patent covers a novel technique ...
Cached Biology Technology:Pediatric Asthma Programs Featuring PARI Pharma's eFlow Acquired by AstraZeneca 2BioStorage Technologies Appoints Lori Ball as Vice President 2BioStorage Technologies Appoints Lori Ball as Vice President 3BioNanomatrix Announces Issuance of Key Nanofluidics Patent Enabling Single Molecule Whole Genome Analysis 2BioNanomatrix Announces Issuance of Key Nanofluidics Patent Enabling Single Molecule Whole Genome Analysis 3
... BD Pathway 435 is an affordable, ... plates and slides, providing a broad ... system rapidly acquires high-resolution images with ... flexible computer-controlled excitation and emission filter ...
... include: Microarray hybridization chamber assembly (1 ... clamp, thumbscrew) Microarray chamber user guide ... intended to be cleaned and reused. The ... Catalog Oligo Microarray kits and all custom ...
... Blood Vessel Staining Kit is a very ... vascular endothelial cells, containing both anti-von Willebrand ... applicable to a variety of species. This ... for the staining of frozen and paraffin-embedded ...
... Coon's Modification of Ham's F-12 was ... produced by viral fusion. The modification consists ... and including ascorbic acid. The salt concentrations ... contains 0.863 mg zinc sulfate per liter, ...
Biology Products: