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Studies offer guide as protein interaction mapping comes of age
Date:1/6/2009

l such studies to draw conclusions about which proteins interact. In examining such studies closely, however, the researchers found that the results overlap rather infrequently. Of some 12,000 interactions that have been identified in yeast cells, 75 percent were reported in one study only. When Cusick and colleagues reviewed 100 of these shakily supported interactions, they could independently substantiate only 25 percent of them.

The authors suggest that the lower-than-expected quality of this data has less to do with the skill of the scientists who handle the data than with the inherent difficulty of extracting information from long, text-heavy documents. "Often, these studies use different reporting guidelines, which makes it difficult to compile results in a uniform way," Cusick remarks. One solution is the molecular interaction experiment initiative, or MIMIx, which standardizes reporting of protein interactions in published manuscripts.

"Interaction mapping is a complex field," Cusick states. "By teasing apart the process of interaction discovery and verification, we've identified where problems are coming from and offered solutions to minimize inconsistencies in the future. This will be critical as efforts continue to map the entire interactome of various species, including humans."


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Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

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