Navigation Links
Studies offer guide as protein interaction mapping comes of age
Date:1/6/2009

interaction is indeed real, and not a false positive reading from a particular type of experiment. The kit is a set of four, high-capacity protein interaction tests that have been weighted in relation to a common set of benchmark data. When scientists identify two proteins as likely interactors, the pair can be tested in the tool kit to obtain a "confidence score" about whether they do, in fact, interact.

"This general approach will allow researchers to systematically and objectively assign confidence scores to all individual protein-protein interactions in cells," says lead author Pascal Braun, PhD. "Such a universally interpretable quality standard is critical for constructing accurate interactome maps."

The third study uses the quality control framework from the first study to compile a new, expanded map of the interactome of the worm Caenorhabditis elegans (C. elegans), a scientific favorite whose cells have roughly the same number of genes as human cells do. The previous version of the map was assembled from studies involving about 2,000 proteins. For the new map, lead author Nicolas Simonis, PhD, of the CCSB and his associates screened some 10,000 protein pairs, documenting 3,864 high quality interactions. The framework enabled the researchers to estimate that the worm's genome includes about 116,000 interactions, meaning that 96 percent of its interactome remains uncharted.

Trust, but verify

Interactome maps are constructed from a variety of sources -- new experiments and data from earlier studies. As Michael Cusick, PhD, and co-authors show in the fourth Nature Methods paper, the information in some of those much-used databases is not as reliable as one would hope.

The team focused on databases built from published studies that involve just a few protein interactions -- an approach sometimes thought to be more accurate than mass-screening techniques. Researchers typically cull information from severa
'/>"/>

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Claims of sex-related differences in genetic association studies often not properly validated
2. Genes, Environment and Health Initiative invests in genetic studies, environmental monitoring
3. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
4. Studies: Children obese due to a host of unhealthy pressures
5. Clinical studies show REMICADE reduces incidence of bowel surgeries in ulcerative colitis patients
6. LSU professor studies army-ant-following birds
7. 2 carotid artery stenting studies show results comparable to AHA guidelines
8. NIH grants enable energy studies
9. New studies on schizophrenia, depression, trauma and autism highlight annual meeting
10. Experts from Stevens, Merck, publish joint paper, Biosynthetic Studies of Platensimycin
11. New studies suggest brain overgrowth in 1-year-olds linked to development of autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2014)... researchers has developed a protein therapy that disrupts the ... original tumor sites, travel through the blood stream and ... This process, known as metastasis, can cause cancer to ... patients who succumb to cancer fall prey to metastatic ... professor of bioengineering who describes a new therapeutic approach ...
(Date:9/19/2014)... new resource unveiled today by researchers from several ... Dublin provides both experienced and aspiring researchers with ... and operate robots made from soft, flexible materials. ... laser cutters, and other advances in manufacturing technology, ... field. Using principles drawn from conventional rigid robot ...
(Date:9/19/2014)... University of Oklahoma biology professor will study multifunctional ... leg movements with a National Science Foundation grant ... project. , Ari Berkowitz, professor in the Department ... will focus on the differences between the multifunctional ... what neurotransmitters they use and what connections they ...
Breaking Biology News(10 mins):Stanford researchers create 'evolved' protein that may stop cancer from spreading 2Stanford researchers create 'evolved' protein that may stop cancer from spreading 3Stanford researchers create 'evolved' protein that may stop cancer from spreading 4Soft robotics 'toolkit' features everything a robot-maker needs 2
... Climate change can greatly impact biological species and ... plans to accommodate habitat shifts. Recorded data ... moved to regions where their climatic requirements are ... managers and regulators on climate change implications for ...
... nature,s beauty as a tourist draw can boost conservation ... automatic ticket out of poverty for the humans who ... those who benefit most from nature-based tourism are people ... harder time breaking into the tourism business, according to ...
... place to enjoy a breath of fresh air may be a ... of graduating seniors has created a system for public transit that ... tuberculosis (TB), flu and pneumonia. The CityBusters Joseph ... seniors have installed a $500 device on a METRO bus ...
Cached Biology News:Workshop to focus on conservation management and climate change 2Can nature's beauty lift citizens from poverty? 2Can nature's beauty lift citizens from poverty? 3College students work to sterilize air, kill pathogens on buses 2College students work to sterilize air, kill pathogens on buses 3College students work to sterilize air, kill pathogens on buses 4
(Date:9/22/2014)... FierceBiotech today announced its annual “Fierce 15” ... 2014. FierceBiotech editors John Carroll and Damian Garde ... Those selected are identified as some of the ... , "It's always a lot of fun to ... said Carroll. "This year in particular you'll find quite ...
(Date:9/22/2014)... METTLER TOLEDO is pleased to ... device CNS110 ScanTape™ . Replacing a traditional ... greater ease and accuracy for transport and logistics ... enhance productivity—an important benefit for load planning and ... profits. , Usable at any point in ...
(Date:9/21/2014)... University of Basel in Switzerland have succeeded in ... molecule for the first time. These extremely weak ... molecular properties and may also contribute to the ... results were published in the scientific journal ... the interaction between matter and light, is probably ...
(Date:9/20/2014)... USA (PRWEB) September 20, 2014 Entries ... 2015 Prism Awards for Photonics Innovation . The ... the multi-billion dollar optics and photonics industry, and is ... and photonics , and Photonics Media . , ... the versatility of photonics, said SPIE CEO Eugene Arthurs. ...
Breaking Biology Technology:FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2ScanTape™ Handheld Dimensioner Increases Processing Volume 2Uncovering the forbidden side of molecules 2Entry deadline is 10 October for international photonics Prism Awards 2Entry deadline is 10 October for international photonics Prism Awards 3Entry deadline is 10 October for international photonics Prism Awards 4
... exclusive interview with new TDS Telecom CEO Dave Wittwer, ... from a phone company to a broadband provider. In this second ... and explains why every TDS employee has a role to play ... , , WTN: How would you describe your approach to ...
... four-part series on intellectual property law. In part I ... risk in copyright cases. In this presentation, she does the ... Liability for officers and directors , , In ... to be personally liable, he or she must personally take ...
... Madison, Wis . - As a result of the ... a Chicago data security provider, the Madison-based network operations ... ,Ambiron, which serves businesses in the payment card industry, ... managed security provider with most of its 50 employees ...
Cached Biology Technology:New CEO at TDS on creating a culture of innovation (Part 2) 2New CEO at TDS on creating a culture of innovation (Part 2) 3New CEO at TDS on creating a culture of innovation (Part 2) 4Intellectual Property: Are you an infringer? 2Intellectual Property: Are you an infringer? 3Intellectual Property: Are you an infringer? 4Sale of SecurePipe won't result in Madison layoffs 2
MBS 384 well satellite block unit with height adjusting heated lid, 384 well block holds 1 x 0.04 ml 384 well plate...
Wellpro 96 an automated liquid handling system for 96-well plates that quickly and accurately prepares large quantities of serial dilutions. The Wellpro also performs plate to plate transfers using ...
Multidrop DW is a high-speed automated dispenser for Deep Well plates, 1.1 ml test tubes and 96-well plates. Designed for accuracy and precision, the Multidrop DW dispenses up to eight different reag...
...
Biology Products: