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Studies of marine animals aim to help prevent rejection of transplanted organs
Date:4/14/2011

(Santa Barbara, Calif.) Studies of the small sea squirt may ultimately help solve the problem of rejection of organ and bone marrow transplants in humans, according to scientists at UC Santa Barbara.

An average of 20 registered patients die every day waiting for transplants, due to the shortage of matching donor organs. More than 110,000 people are currently waiting for organ transplants in the U.S. alone. Currently, only one in 20,000 donors are a match for a patient waiting for a transplant.

These grim statistics drive scientists like Anthony W. De Tomaso, assistant professor of biology at UCSB, to delve into the cellular biology of immune responses. His studies of the sea squirt shed light on the complicated issue of organ rejection. The latest results are published online today in the journal Immunity.

De Tomaso hopes to understand how it might be possible to "tune" the body's immune response in order to dial down the rejection of a donated organ. Studying cellular responses in simple organisms may also eventually help with autoimmune diseases those in which the body mistakenly attacks itself.

"Right now, when you get a transplant, you're usually on immunosuppressives your whole life," said De Tomaso. "And that's like sort of kicking your immune system in the teeth. What if we could raise the threshold of when you would respond, instead of just shutting the whole system off?"

De Tomaso and his research team study Botryllus schlosseri, a type of sea squirt. This small organism known as a tunicate because of its covering, or "tunic" is a modern day descendant of the vertebrate ancestor, the group to which we belong. Tunicates begin life as swimming tadpoles with primitive backbones, nerves, and musculature that are similar to all vertebrates, but soon transform into stationary creatures. Tunicates latch onto intertidal surfaces and look like flat flowers with each "petal" being a separate, but genetic
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Contact: Gail Gallessich
gail.g@ia.ucsb.edu
805-893-7220
University of California - Santa Barbara
Source:Eurekalert  

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