Navigation Links
Studies in Cell Transplantation investigate oxygen's impact as a factor in transplantation
Date:11/15/2012

tors of reactive oxygen species (ROS) homeostasis, among other processes. Understanding the role of oxygen metabolism in both the diseased brain and throughout development is critical to elucidating pathophysiological mechanisms in psychiatric disorders." According to the research team, the use of oxygen consumption as an index of oxidative metabolism has been applied for decades and revealed important mechanisms and enzyme activities.

When researchers investigated oxygen consumption and ROS level changes in neural cells derived from the reprogrammed fibroblasts of a schizophrenic patient, their analysis showed "altered extra-mitochondrial oxygen consumption associated with an increase in the levels of ROS."

Our results provide the first evidence of a developmental metabolic alteration in schizophrenia, which can be reverted by pharmacological intervention since the neuroenergetic failure in increased ROS production may have emerged during neural differentiation," said Rehen. They concluded that not only might metabolic changes during neurogenesis contribute to the development of schizophrenia, but might also represent an important target for treatment.

Contact: Dr. Stevens K. Rehen, National Laboratory for Embryonic Stem Cell Research, UFRJ, Hospital Universitario Clementino Fraga Filho HUCFF, Rua Rodolpho Paulo Rocco, 255 4 andar CEPEDIP Cidade Universitaria Rio de Janeiro RJ, Brasil.
Tel. +55-21-2562-2928
Email: srehen@lance-ufrj.org

Citation:. Paulsen, B. da S.; Maciel, R. de M.; Galina, A.; da Silveira, M. S.; Souza, C. dos S.; Drummond, H.; Pozzatto, E. N.; Junior, H. S.; Chicaybam, L.; Massuda, R.; Setti-Perdigo, P.; Bonamino, M.; Belmonte-de-Abreu, P. S.; Castro, N. G.; Brentani, H.; Rehen, S. K. Altered Oxygen Metabolism Associated to Neurogenesis of Induced Pluripotent Stem Cells Derived From a Schizophrenic Patient. Cell Transplant. 21(7):1547-1559; 2012.


'/>"/>

Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Studies reveal structure of EV71, a virus causing childhood illnesses
2. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
3. Autism Speaks awards $1.1 million to fund high priority studies
4. Improving equine health: Research studies vaccinations to protect newborn foals
5. Miniature Sandia sensors may advance climate studies
6. 2 Cell Transplantation studies impact dental stem cell research for therapeutic purposes
7. GSA Bulletin presents studies in Antarctica, Italy, Mexico, Algeria, Mongolia, and more
8. Preclinical studies use specialized ultrasound to detect presence of cancer
9. FirstMark Scientific Board of Advisors Meet to Discuss New Clinical Studies for PREvent
10. New studies show spinal cord injury and ALS respond to cell transplantation
11. First GWAS studies of obsessive-compulsive disorder and Tourette syndrome published
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... LLC, a company engaged in biometric identification is an ... portion of the recently awarded TIES (Technical Information Engineering ... Army. 3D-ID LLC has a suite of ... and security agencies. Gino Pereira , ...
(Date:5/19/2015)... , May 19, 2015 ... has announced the addition of the  "Genetic ... offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent ... an in-depth analysis of the current and ... of gene-based tests, their working principles and ...
(Date:5/14/2015)... 14, 2015  Verificient Technologies, Inc., a ... online remote proctoring, announced a new alliance ... and creator of the Canvas Learning Management ... companies will benefit from the seamless integration ... As a fully integrated multifactor biometrics behavioral ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3Global Genetic Testing Market Outlook 2018 2Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2
... levels of folate in their red blood cells were more ... a chemical off switch for genes, researchers report in the ... co-author Jean-Pierre Issa, M.D., professor in MD Anderson,s Department of ... of aging, such as heart disease. Methyl groups attach to ...
... 2010)A class of drugs thought to kill cancer cells may ... normal immune cells, resulting in reduced cancer growth and spreada ... evaluated in the future. Researchers at the University of ... fifth most common cancer in the United States. Bladder cancer ...
... release of an online tool that will help scientists ... a cell,s transcription machinery where to start reading in ... Promoter Database (MPromDb) integrates the genome sequencing data generated ... mouse genomics. MPromDb pinpoints known promoters and predicts where ...
Cached Biology News:High red blood cell folate levels linked to silenced tumor-suppressors 2High red blood cell folate levels linked to silenced tumor-suppressors 3Some cancer drugs may block cellular 'cross talk' but not kill cancer cells 2New annotated database sifts through mountains of sequencing data to find gene promoters 2New annotated database sifts through mountains of sequencing data to find gene promoters 3
(Date:6/2/2015)... CA (PRWEB) June 02, 2015 German-based ... official United States distributor for the Moenninghoff product ... stated, “I am pleased to announce that the R.M. ... market. For our firm, founded in 1916, this is ... R.M. Hoffman is the kind of professional distributor we ...
(Date:6/1/2015)... 1, 2015 Research ... the addition of the "Oxidative Stress ... Test Type (Indirect, Enzyme-based, Reactive Oxygen Species ... Users - Global Forecast to 2020" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , The global ...
(Date:6/1/2015)... 2015 About Bio-alcohols Bio-alcohols ... or cellulose. Bio-alcohols are primarily used in the transportation ... replacement for gasoline in cars. Technavio,s analysts forecast the ... 9 percent over the period 2014-2019. ... be segmented into five: transportation, infrastructure, medical, and others. ...
(Date:6/1/2015)...  The Val Skinner Foundation is partnering with Discovery ... high school students focused on cancer genetics. Skinner made ... Event (LPGA Pros in the Fight to Eradicate breast ... West Caldwell, N.J. Skinner ... than $500,000 on Monday, bringing the foundation,s 16-year total ...
Breaking Biology Technology:R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 2R.M. Hoffman Company designated official United States distributor for the Moenninghoff product line. 3Oxidative Stress Assay Market 2015 - Global Forecast to 2020 2Global Bio-alcohols Market 2015-2019 2Val Skinner Foundation Announces Partnership With Discovery Education 2
... May 25, 2011 /PRNewswire/ -- Vermillion, ... today announced that the United States Patent and Trademark Office ... entitled "Saposin D and Fam3C are Biomarkers for Alzheimer,s Disease." ... as well as combinations that include these biomarkers. ...
... 2011 VIVUS, Inc. (NASDAQ: ... 3, placebo-controlled clinical trial of the investigational drug avanafil ... following a radical prostatectomy. The study (REVIVE-RP, TA-303) met ... erectile function as measured by the Sexual Encounter Profile ...
... 24, 2011 Spherix Incorporated (NASDAQ: ... in diabetes, metabolic syndrome and atherosclerosis, and providers ... supplement, biotechnology and pharmaceutical companies – today announced ... rule 5550(a)(2), which concerns minimum bid price listing ...
Cached Biology Technology:Vermillion Announces Notice of Allowance for Alzheimer Patent 2Vermillion Announces Notice of Allowance for Alzheimer Patent 3VIVUS Announces Positive Phase 3 Results of Avanafil in Radical Prostatectomy Patients 2VIVUS Announces Positive Phase 3 Results of Avanafil in Radical Prostatectomy Patients 3VIVUS Announces Positive Phase 3 Results of Avanafil in Radical Prostatectomy Patients 4VIVUS Announces Positive Phase 3 Results of Avanafil in Radical Prostatectomy Patients 5Spherix Regains Compliance With NASDAQ Listing Rule 2
... Factor XIII in both reduced and non-reduced ... XIII B-chain or human Factor XII. Factor XIII ... composed of two subunits. Factor XIII-A is the ... 160kDa. Factor XIII is present in plasma as ...
... Anti-Lipid Phosphate Phosphatase 2 ... buffered aqueous solution ... saline containing 0.08% sodium ... from the human LPP2 ...
Anti-CaM kinase II recognizes the enzymes a subunit (6) and reacts with tissue from all mammalian species tested, as well as with chicken and frog tissues....
... Anti-MAPKAPK-2, Phospho-Specific(Thr 222 ) ... NaCl, 10 mM sodium HEPES, ... pH 7.5. Recognizes the ~47 ... 2 (MAPKAPK-2) protein phosphorylated at ...
Biology Products: