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Studies in Cell Transplantation investigate oxygen's impact as a factor in transplantation
Date:11/15/2012

tors of reactive oxygen species (ROS) homeostasis, among other processes. Understanding the role of oxygen metabolism in both the diseased brain and throughout development is critical to elucidating pathophysiological mechanisms in psychiatric disorders." According to the research team, the use of oxygen consumption as an index of oxidative metabolism has been applied for decades and revealed important mechanisms and enzyme activities.

When researchers investigated oxygen consumption and ROS level changes in neural cells derived from the reprogrammed fibroblasts of a schizophrenic patient, their analysis showed "altered extra-mitochondrial oxygen consumption associated with an increase in the levels of ROS."

Our results provide the first evidence of a developmental metabolic alteration in schizophrenia, which can be reverted by pharmacological intervention since the neuroenergetic failure in increased ROS production may have emerged during neural differentiation," said Rehen. They concluded that not only might metabolic changes during neurogenesis contribute to the development of schizophrenia, but might also represent an important target for treatment.

Contact: Dr. Stevens K. Rehen, National Laboratory for Embryonic Stem Cell Research, UFRJ, Hospital Universitario Clementino Fraga Filho HUCFF, Rua Rodolpho Paulo Rocco, 255 4 andar CEPEDIP Cidade Universitaria Rio de Janeiro RJ, Brasil.
Tel. +55-21-2562-2928
Email: srehen@lance-ufrj.org

Citation:. Paulsen, B. da S.; Maciel, R. de M.; Galina, A.; da Silveira, M. S.; Souza, C. dos S.; Drummond, H.; Pozzatto, E. N.; Junior, H. S.; Chicaybam, L.; Massuda, R.; Setti-Perdigo, P.; Bonamino, M.; Belmonte-de-Abreu, P. S.; Castro, N. G.; Brentani, H.; Rehen, S. K. Altered Oxygen Metabolism Associated to Neurogenesis of Induced Pluripotent Stem Cells Derived From a Schizophrenic Patient. Cell Transplant. 21(7):1547-1559; 2012.


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Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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