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Studies in Cell Transplantation investigate oxygen's impact as a factor in transplantation
Date:11/15/2012

d Matsumoto. HMGB1 has been shown to play a role in response to tissue damage, so the researchers also examined HMGB1 expression and the amount of HMGB1 released from each group of islets. They demonstrated that the islets at 37oC up-regulated HMGB1 mRNA, although this was prevented by low temperature conditions. Conversely, the amount of released HMGB1 was "significantly decreased in the cells at 4oC."

The researchers concluded that correspondingly low temperature conditions can prevent hypoxic islet cell damage and that low levels of HMGB1 released from islets might reduce inflammatory responses after transplantation.

"Maintaining low temperature conditions during islet isolation should improve the efficacy of islet isolation in a clinical setting," said the researchers.

Contact: Dr. Shinichi Matsumoto, Baylor Research Institute, Islet Cell Laboratory, 1400 8th Ave., Fort Worth, Texas, 76104.
Email: shinichi41@mac.com

Citation: Itoh, T.; Sugimoto, K.; Takita, M.; Shimoda, M.; Chujo, D.; SoRelle, J. A.; Naziruddin, B.; Levy, M. F.; Matsumoto, S. Low Temperature Condition Prevents Hypoxia-Induced Islet Cell Damage and HMGB1 Release in a Mouse Model. Cell Transplant. 21(7):1361-1370; 2012.

Altered oxygen metabolism associated with iPS cells derived from schizophrenic patient

Researchers found that neural cells derived from induced pluripotent stem cells (iPSCs) generated from skin fibroblasts of a schizophrenic patient demonstrated a twofold increase in extra-mitochondrial oxygen consumption as well as elevated levels of reactive oxygen species (ROS). Their work could contribute to a better understanding of schizophrenia's development as a neurodevelopmental disease, they said.

"Brain mitochondria play a key role in neuroenergetics," said study co-author Dr. Stevens K. Rehen of Brazil's National Laboratory for Embryonic Stem Cell Research. "They are essential regula
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Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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