Navigation Links
Studies identify spinal cord neurons that control skilled limb movement
Date:5/1/2014

new that such neurons are unlikely to be responsible for fine-tuning the sensory signal," said lead author Andrew J. P. Fink, PhD, a former graduate student in Dr. Jessell's lab. "Postsynaptic inhibition affects the entire neuron, and motor neurons receive many different inputs. So a mechanism that shut down the motor neuron to all of its inputs would lack refinement."

Researchers have long speculated that one subset of GABAergic interneurons might regulate movement by controlling the strength of sensory feedback signals from muscles. "These particular neurons are known to work presynaptically, by forming direct connections with the terminals of sensory neurons and suppressing the release of sensory neurotransmitter," said Dr. Fink. For technical reasons, the function of these interneurons, if any, in motor behavior has remained elusive.

Dr. Fink and his colleagues identified a way to access this subset of interneurons genetically in mice and then devised approaches to manipulate their function in a selective manner. In one experiment, they activated presynaptic inhibitory interneurons optogenetically, decreasing the strength of sensory-motor transmission. They also ablated these interneurons by making them selectively sensitive to a lethal toxin, abolishing their control over sensory feedback strength. Without sensory feedback regulation, forelimb movements were dominated by severe oscillatory tremors, drastically diminishing motor accuracy.

This finding, along with parallel modeling studies, indicates that presynaptic inhibitory neurons normally adjust the "gain" of sensory feedback at synapses with motor neurons and are therefore crucial for the smooth execution of movement. Understanding how these basic microcircuits regulate sensory input and motor output may, in the long run, provide insight into ways to combat the movement instability and tremor seen in many neurological disorders.

"These two studies shed new light on
'/>"/>

Contact: Karin Eskenazi
ket2116@cumc.columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Simple sequence repeats for population-level studies of pines
2. Studies affirm crabs killing Northeast saltmarshes
3. Genome-wide association studies mislead on cardiac arrhythmia risk gene
4. Studies of gut flora in infants and toddlers could lead to better health
5. New studies needed to predict how marine organisms may adapt to the futures acidic oceans
6. Are enough women included in medical device studies, as required by the FDA?
7. Island channel could power about half of Scotland, studies show
8. Plant cell growth studies funded by NSF grant at UMass Amherst
9. Most clinical studies on vitamins flawed by poor methodology
10. Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
11. H. pylori vaccine shows promise in mouse studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Studies identify spinal cord neurons that control skilled limb movement
(Date:11/12/2014)... GARDENS, Fla. , Nov. 12, 2014 ... announced today that its U.are.U ® fingerprint readers ... bakery chain in Central Mexico . ... June 2014 to eliminate payroll issues caused by employees ... to installing the U.are.U fingerprint readers, Montparnasse relied on ...
(Date:11/7/2014)... 6, 2014 Leading Biometric companies aim ... security revolutionizing online transactions.  Companies in focus today are: NXT-ID, ... BABA ), Google Inc. (NASDAQ: GOOG ... (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: MA) ... NXTDW), a biometric authentication company focused on the growing mobile ...
(Date:11/5/2014)... of biology in the UTSA College of Sciences, ... selected to receive a two-year $300,00 National Science ... (EAGER). The funding supports President Obama,s BRAIN Initiative, ... new technology that will demystify complex brain processes. ... neuroscience are broken into the interactions of multiple ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... looked at consumers who buy locally grown and ... programs found the venues largely attract a "privileged" ... a need for broadening local food opportunities beyond ... and strategic efforts that make fresh foods accessible ...
... Primates, brains see the world through triangular grids, according ... journal Nature . Scientists at Yerkes National ... neurons that fire in repeating triangular patterns as the ... monkeys. The finding has implications for understanding how ...
... The ability of embryonic stem cells to differentiate into ... and maintained by a complex series of chemical interactions, ... process could prove useful for stem cell-based therapies down ... Carnegie,s Yixian Zheng zeroes in on the process by ...
Cached Biology News:Greater effort needed to move local, fresh foods beyond 'privileged' consumers 2Primates' brains make visual maps using triangular grids 2Primates' brains make visual maps using triangular grids 3Solving stem cell mysteries 2
(Date:11/26/2014)... Morristown, NJ (PRWEB) November 25, 2014 ... it has officially joined the Morris County (New ... MCCC, which is a leading business organization in ... unique opportunity to further engage some key clients ... have operations in the geographic area. Membership enables ...
(Date:11/26/2014)... Global biostimulants market is expected to ... estimated CAGR of 12.5%. In order to cater ... least ecological impacts, farmers are looking to adopt ... yield more effectively & efficiently. Biostimulants are consequently ... return on investments. , Leading companies in the ...
(Date:11/26/2014)... TOKYO , 25 novembre 2014 Theravalues ... Super sur le marché européen au salon Hi ... Amsterdam ). Curcumine la ... une technologie amorphe (non-cristalline) à des ingrédients approuvés ... est un pigment jaune présent dans la racine ...
(Date:11/24/2014)... -- Five American winners will receive the ... for Medical Sciences", in its 8 th term; ... , on 15 December 2014.      (Photo: ... Center which won the Hamdan Award for Volunteers in ... that aim to improve health and promote peace and ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 22019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 32019 Biostimulants Market to Grow at a CAGR of 12.5% Says a New Research Report Available at RnRMarketResearch.com 4La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3Five US Winners Among Recipients of Hamdan Medical Awards 2
... Corporation,(Nasdaq: DNDN ) today announced that it ... 8.0 million shares of its common,stock and warrants ... its common,stock. Net proceeds received by Dendreon were ... sole placement agent for the offering., The ...
... Diffusion,Pharmaceuticals LLC, a clinical-stage drug-development company,commercializing drugs ... enhances,oxygen diffusion, today announced that it has ... Trans Carotenoid Salts and Their Uses." This,patent ... new chemical entities,known as trans biopolar carotenoid ...
... 2008 ShapeGrabber and Nikon,Instruments Inc. today ... as a,sales distribution channel in the United ... scanner inspection systems. This arrangement will,increase ShapeGrabber,s ... enabling Nikon to provide customers with,additional non-contact ...
Cached Biology Technology:Dendreon Announces Closing of Registered Direct Offering 2Diffusion Pharmaceuticals Announces Issuance of U.S. Patent No. 7351844, Titled 'Bipolar Trans Carotenoid Salts and Their Uses,' for Its Family of First-In-Class Molecules 2ShapeGrabber and Nikon Instruments Inc. Announce Distribution Agreement 2
... a Perkin Elmer UltraVIEW system and want to ... and iQ software? No problem. Our experienced ... your existing microscope, lasers, Sutter filter wheel, Piezo ... work with our precision controller unit and workstation... ...
... Variable Speed Rocker, with 12" x 14" table; ... x 14" table; 220V. The VSR-50 Variable ... for any lab. The VSR-50 provides a rhythmic ... a gentle to vigourous movement. This makes it ...
...
...
Biology Products: