Navigation Links
Studies identify spinal cord neurons that control skilled limb movement
Date:5/1/2014

new that such neurons are unlikely to be responsible for fine-tuning the sensory signal," said lead author Andrew J. P. Fink, PhD, a former graduate student in Dr. Jessell's lab. "Postsynaptic inhibition affects the entire neuron, and motor neurons receive many different inputs. So a mechanism that shut down the motor neuron to all of its inputs would lack refinement."

Researchers have long speculated that one subset of GABAergic interneurons might regulate movement by controlling the strength of sensory feedback signals from muscles. "These particular neurons are known to work presynaptically, by forming direct connections with the terminals of sensory neurons and suppressing the release of sensory neurotransmitter," said Dr. Fink. For technical reasons, the function of these interneurons, if any, in motor behavior has remained elusive.

Dr. Fink and his colleagues identified a way to access this subset of interneurons genetically in mice and then devised approaches to manipulate their function in a selective manner. In one experiment, they activated presynaptic inhibitory interneurons optogenetically, decreasing the strength of sensory-motor transmission. They also ablated these interneurons by making them selectively sensitive to a lethal toxin, abolishing their control over sensory feedback strength. Without sensory feedback regulation, forelimb movements were dominated by severe oscillatory tremors, drastically diminishing motor accuracy.

This finding, along with parallel modeling studies, indicates that presynaptic inhibitory neurons normally adjust the "gain" of sensory feedback at synapses with motor neurons and are therefore crucial for the smooth execution of movement. Understanding how these basic microcircuits regulate sensory input and motor output may, in the long run, provide insight into ways to combat the movement instability and tremor seen in many neurological disorders.

"These two studies shed new light on
'/>"/>

Contact: Karin Eskenazi
ket2116@cumc.columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Simple sequence repeats for population-level studies of pines
2. Studies affirm crabs killing Northeast saltmarshes
3. Genome-wide association studies mislead on cardiac arrhythmia risk gene
4. Studies of gut flora in infants and toddlers could lead to better health
5. New studies needed to predict how marine organisms may adapt to the futures acidic oceans
6. Are enough women included in medical device studies, as required by the FDA?
7. Island channel could power about half of Scotland, studies show
8. Plant cell growth studies funded by NSF grant at UMass Amherst
9. Most clinical studies on vitamins flawed by poor methodology
10. Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
11. H. pylori vaccine shows promise in mouse studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Studies identify spinal cord neurons that control skilled limb movement
(Date:5/10/2015)... May 11, 2015 Fingerprint Cards (FPC) ... and FPC1155 from the distributor World Peace Industrial Group (WPI), ... in Asia . Deliveries are planned to ... used by smartphone manufacturers in China . ... communicated revenue guidance of + 1 000 MSEK for 2015.   ...
(Date:4/27/2015)...  For more than four decades, AUVSI,s Unmanned ... premier worldwide event for the unmanned land, sea, and ... for any local, national, or trade news organization interested ... and current applications of unmanned technologies. The conference will ... billion industry, and how it will soon impact the ...
(Date:4/20/2015)... -- The announcement comes as demand for ... (GRM), Ireland,s foremost records management company, ... up an impressive track record of clients within the first ... records management sector in Dubai . As ... and employ a further eight staff members at its Irish ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 235 Million 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... Mo. A delay in traffic may cause a ... cause much more. University of Missouri researchers have uncovered ... of the nervous system and found that the proteins ... do not. Understanding how the nervous system develops will ...
... LAS CRUCES, NMPhytophthora blight, caused by Phytophthora capsici ... many crop species worldwide, including chile peppers in New ... caused less damage in pepper crops of the hot ... published in the October 2008 issue of HortScience ...
... Estuarine, Coastal and Shelf Science , University of Miami ... Glynn, and 2008 Pew Fellow for Marine Conservation and Assistant ... data on reef ecosystems recovery from climate change-related episodes of ... symbiotic algal partners and turn pale or white is ...
Cached Biology News:Researchers disprove 15-year-old theory about the nervous system 2Does hotter mean healthier? 2Long-term recovery of reefs from bleaching requires local action to increase resilience 2
(Date:6/3/2015)... June 03, 2015 Global Stem ... Inc. have announced plans to conduct Romania’s first ever ... Through an alliance with Miami-based Stem Cell Training, Inc., ... the Adipose and Bone Marrow Stem Cell Training Course ... reconstructive plastic surgery specialist practicing in Bucharest and Tel ...
(Date:6/2/2015)... , June 2, 2015 TapImmune, Inc. (OTCQB: ... institutional investors have reached an agreement whereby the institutional ... term warrants to provide the Company up to $4.93M ... effective S-1 registration statement. Under the restructured terms and ... call additional warrants which could result in a larger ...
(Date:6/2/2015)... Research and Markets ( http://www.researchandmarkets.com/research/6wjpd6/bioburden_testing ) has ... by Product , Test, Application & End User - ... The bioburden testing market is expected to reach ... growing at a CAGR of 9.8% from 2014 to ... limit testing market is segmented into consumables and instruments. ...
(Date:6/2/2015)... Meet ARGUS, The World,s First ... Read People. Analyze emotions and predict actions. Explore a ... very first Responsive-RPG: "The Eye: Genesis".      ... , , https://www.youtube.com/watch?v=B1ZEtAZ2Yf8 ... inner feelings - and those of others. Being able ...
Breaking Biology Technology:Global Stem Cells Group Announces First Stem Cell Training Course to Take Place in Romania 2Global Stem Cells Group Announces First Stem Cell Training Course to Take Place in Romania 3TapImmune Announces Agreement To Facilitate Near Term Capital Infusion; Expediting Path Toward Phase II Trial Initiation 2TapImmune Announces Agreement To Facilitate Near Term Capital Infusion; Expediting Path Toward Phase II Trial Initiation 3Bioburden Testing Market 2015 - Global Forecasts to 2019 2ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 2ARGUS - The World's First Inner Emotion Scanner Launches on KickStarter 3
... and Preclinical-Stage Compounds ... in Merck KGaA ... drug discovery and development company, announced today that,it will collaborate ... discover new applications for drug candidates. KineMed,s,proprietary pathway-based drug discovery ...
... CHELMSFORD, Mass., Aug. 28 Magellan Biosciences, ... that,Steven E. Diamond, PhD, has joined the ... to Magellan from Siemens Medical Solutions Diagnostics,(formerly ... research and,development, for the point-of-care product lines: ...
... Laboratories, a national,clinical and anatomic pathology reference laboratory ... announced today that it has,renewed a multisource group ... the nation,s largest purchasing alliances of leading,hospitals and ... between ARUP and Premier which has been in ...
Cached Biology Technology:KineMed to Collaborate With Merck KgaA to Validate New Applications for Drug Development Candidates 2Magellan Biosciences Names Steven E. Diamond, PhD, Chief Scientific Officer 2Magellan Biosciences Names Steven E. Diamond, PhD, Chief Scientific Officer 3ARUP Laboratories and Premier Extend Contract for Reference Laboratory Testing Services 2
Chicken polyclonal to ADI1 ( Abpromise for all tested applications). Antigen: Full length native protein (purified), corresponding to amino acids 1-179 of Human ADI1. Entrez GeneID: 55256 ...
Request Info...
anti-JNK2 Immunogen: Recombinant human JNK2 protein Accession Number: NM_002752 Quality Assurance: Routinely evaluated by immunoblot. Molecular Weight: 46 and/or 54 kDa Available ...
... 5B15-5B-11E. Immunogen: Synthetic peptide derived from ... protein. Specificity: Specific for the ... Western blots it identifies the target band ... (positive controls: deglycosylated secreted media from primary ...
Biology Products: