Navigation Links
Studies identify spinal cord neurons that control skilled limb movement
Date:5/1/2014

new that such neurons are unlikely to be responsible for fine-tuning the sensory signal," said lead author Andrew J. P. Fink, PhD, a former graduate student in Dr. Jessell's lab. "Postsynaptic inhibition affects the entire neuron, and motor neurons receive many different inputs. So a mechanism that shut down the motor neuron to all of its inputs would lack refinement."

Researchers have long speculated that one subset of GABAergic interneurons might regulate movement by controlling the strength of sensory feedback signals from muscles. "These particular neurons are known to work presynaptically, by forming direct connections with the terminals of sensory neurons and suppressing the release of sensory neurotransmitter," said Dr. Fink. For technical reasons, the function of these interneurons, if any, in motor behavior has remained elusive.

Dr. Fink and his colleagues identified a way to access this subset of interneurons genetically in mice and then devised approaches to manipulate their function in a selective manner. In one experiment, they activated presynaptic inhibitory interneurons optogenetically, decreasing the strength of sensory-motor transmission. They also ablated these interneurons by making them selectively sensitive to a lethal toxin, abolishing their control over sensory feedback strength. Without sensory feedback regulation, forelimb movements were dominated by severe oscillatory tremors, drastically diminishing motor accuracy.

This finding, along with parallel modeling studies, indicates that presynaptic inhibitory neurons normally adjust the "gain" of sensory feedback at synapses with motor neurons and are therefore crucial for the smooth execution of movement. Understanding how these basic microcircuits regulate sensory input and motor output may, in the long run, provide insight into ways to combat the movement instability and tremor seen in many neurological disorders.

"These two studies shed new light on
'/>"/>

Contact: Karin Eskenazi
ket2116@cumc.columbia.edu
212-342-0508
Columbia University Medical Center
Source:Eurekalert  

Page: 1 2 3 4 5

Related biology news :

1. Simple sequence repeats for population-level studies of pines
2. Studies affirm crabs killing Northeast saltmarshes
3. Genome-wide association studies mislead on cardiac arrhythmia risk gene
4. Studies of gut flora in infants and toddlers could lead to better health
5. New studies needed to predict how marine organisms may adapt to the futures acidic oceans
6. Are enough women included in medical device studies, as required by the FDA?
7. Island channel could power about half of Scotland, studies show
8. Plant cell growth studies funded by NSF grant at UMass Amherst
9. Most clinical studies on vitamins flawed by poor methodology
10. Rheumatoid arthritis research shows the potential of large-scale genetic studies for drug discovery
11. H. pylori vaccine shows promise in mouse studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Studies identify spinal cord neurons that control skilled limb movement
(Date:8/27/2014)... , Aug. 27, 2014 /PRNewswire-iReach/ -- The IEEE Engineering ... 36 th Annual International Conference (EMBC,14), this year ... in Chicago, Illinois , from Tuesday, ... global leaders, students, and industry professionals in science, medicine, ... - http://photos.prnewswire.com/prnh/20140827/140333 This year,s ...
(Date:8/27/2014)... long-standing belief that a deficiency in serotonin a ... role in depression. In the journal ACS Chemical ... to make serotonin in their brains (and thus should ... depression-like symptoms. , Donald Kuhn and colleagues at ... State University School of Medicine note that depression poses ...
(Date:8/27/2014)... thought to be associated with outcomes after the ... of the patient, mechanism of injury, nerve injured, ... operation technique, and repair materials. However, despite numerous ... nerve injuries, there is no agreement regarding the ... dose-effect relationship of the predictors has not been ...
Breaking Biology News(10 mins):Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 2Global Leaders In Science, Medicine, And Engineering Gather For The 36th Annual International Conference Of The IEEE Engineering In Medicine And Biology Society, August 26-30 In Chicago 3New study throws into question long-held belief about depression 2
... can sail throughout the body via the bloodstream without ... ferry their cargo of anti-cancer drugs and markers into ... In a forthcoming issue of the Germany-based chemistry journal ... UC Santa Barbara and MIT report that their nano-cargo-ship ...
... North Hollywood, CA September 11, 2008 - ... advocacy and support for myeloma patients, families, researchers and ... with multiple myeloma, cancer in the bone marrow that ... edition of the Journal of Clinical Oncology *, ...
... are bracing for Hurricane Ike as it travels over the ... Envisat satellite is tracking the storm, which is forecast to ... Knowing the strength and path of hurricanes is critical for ... of providing synoptic data on the forces that power the ...
Cached Biology News:Researchers develop nano-sized 'cargo ships' to target and destroy tumors 2Researchers develop nano-sized 'cargo ships' to target and destroy tumors 3Researchers develop nano-sized 'cargo ships' to target and destroy tumors 4The IMF says journal editorial documents dramatic increase in survival since the 1980s 2Hurricane Ike tracked by ESA's Envisat 2
(Date:8/28/2014)... (PRWEB) August 28, 2014 Whitehouse Laboratories ... long term partnership with PTI Inspection Systems ... with state of the art leak testing method development ... art instruments currently available. As part of this agreement, ... High Voltage Leak Detection Instrument developed and manufactured ...
(Date:8/27/2014)... 2014 Reportlinker.com announces that a ... its catalogue: Global Biodegradable Packaging ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html About Biodegradable Packaging ... readily decomposed by the action of microorganisms. ... in terms of raw materials, production technology, ...
(Date:8/27/2014)... Aug. 27, 2014 Research and ... "Global Lactic Acid  (Biodegradable Polymer, Food & Beverage, ... Forecasts to 2019" report to their offering. ... acid with an asymmetrical carbon atom. The main ... polymer, food and beverage, personal care product, and ...
(Date:8/27/2014)... Aug. 27, 2014 Reportbuyer.com has added ... Graphene Opportunity - A Rational View ... New Nanotech? A similar amount of hype ... ranging from microelectronics to water treatment, but is ... availability of the Graphene Opportunity Report, authored by ...
Breaking Biology Technology:Whitehouse Labs Renews Partnership with PTI Inspection Systems 2Whitehouse Labs Renews Partnership with PTI Inspection Systems 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7Global Lactic Acid (Biodegradable Polymer, Food & Beverage, Personal Care & Pharmaceutical) Market - Trends & Forecasts to 2019 2The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ) today announced ... stockholders, with part of the proceeds from the $300 million ... shares of PDL on December 1, 2009 will be paid ... a significant amount of convertible securities outstanding, the amount of ...
... ... ... 12, 2009 – Tackling global food security requires an understanding of local situations ... international scale, DuPont Vice President and Pioneer Hi-Bred Chairman Dean Oestreich told a ...
... RIDGE, N.J., Nov. 12 Regado Biosciences, a privately ... active control agents, announced that David Mazzo, PhD, CEO ... Markets 6th Annual Healthcare Conference at the St. Regis ... be given at 1:10pm (EST) on Tuesday, November 17 ...
Cached Biology Technology:PDL BioPharma Announces Special Dividend Payment 2Start Locally, Collaborate to Increase Food Security, Says DuPont Leader to U.N. Group 2Start Locally, Collaborate to Increase Food Security, Says DuPont Leader to U.N. Group 3Start Locally, Collaborate to Increase Food Security, Says DuPont Leader to U.N. Group 4Regado Biosciences to Present at the Lazard Capital Markets 6th Annual Healthcare Conference on November 17, 2009 2
...
... Solution, High pH, Concentrated x 10 ... heat-induced target retrievel prior to immunohistochemical staining ... paraffin-embedded tissue sections mounted on glass slides. ... pH, 9.9, is especially effective. It should ...
... solid. Increases the expression of glutathione peroxidase. ... 2 O. Unstable in aqueous solutions; reconstitute ... 3211-76-5, M.W. 196.1. References: Merck Index ... A.F. 1995. Biochem. J. 306, ...
... UN-SCAN-IT gel Software converts any scanner into ... numerous options and features, the basic operation ... JPEG, PCX, BMP, etc.) into pixel density ... steps. Turn your scanner ...
Biology Products: