atory approval in Nigeria, partnered with US-based firm XeChem, demonstrated clinical efficacy and safety, and were awarded valuable "orphan" drug status by the US Food and Drug Administration.
Niprisan failed to achieve mainstream success, however, due to a number of problems, such as insufficient manufacturing capacity, quality control issues, pricing and distribution, and lack of financing. Today, NIPRD is considering options for another commercial partner to take the drug forward.
The paper cites five key lessons learned for policy-makers and entrepreneurs:
- Make benefit-sharing agreements with traditional medical healers whose knowledge is used.
- Seek partners to fill gaps in knowledge and technical expertise.
- Subsidize clinically-proven new drugs derived from traditional medicines, where the disease is endemic to a region and good alternative treatments are lacking.
- Institute standardization and quality control measures in drug manufacturing, especially for traditional medicines, the potency and effectiveness of which can be influenced by the raw materials involved (i.e. plant material quality, age, time of harvest, location, soil quality, preparation, handling, etc.).
- Train skilled entrepreneurial leaders to manage partnerships, recruit talented professionals, approach government for funding, and handle the missteps and breakthroughs that go along with early stage drug development.
Venture funding for science-based African health innovation
Authors Hassan Masum, Justin Chakma, Ken Simiyu, Wesley Ronoh, Abdallah S Daar and Peter A. Singer describe case studies of five health venture funds based in the developing world, and suggest lessons.
The five funds included publicly-owned organizations, corporations, social enterprises, and subsidiaries of foreign venture firms. Three funds aimed primarily for financial returnsPage: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 Related biology news :1
. Genetic studies of human evolution win researcher 2011 Gani Medal2
. PAREXEL Completes 200 Patient Studies In Its Early Phase Units Over Three Years3
. Virginia Tech studies impact of Gulf oil spill on plovers4
. Japanese researchers report on liver transplantation studies using animal and iPS cells5
. Squid studies provide valuable insights into hearing mechanisms6
. Studies provide new insights into the genetics of obesity and fat distribution7
. Got fish? Nutrition studies explore health benefits8
. Grant advances quark-gluon plasma studies
. Thesis studies atmospheric PM contaminant in the Basque Autonomous Community10
. NIH grants will advance studies of the form and function of proteins11
. Marshall University researchers awarded more than $1 million for breast cancer studies