Navigation Links
Structure of protective protein in the eye lens revealed
Date:7/31/2009

The human eye lens consists of a highly concentrated mix of several proteins. Protective proteins prevent these proteins from aggregating and clumping. If this protective function fails, the lens blurs and the patient develops cataracts. Two research groups at the Department of Chemistry of the Technische Universitaet Muenchen (TUM) have succeeded in explaining the molecular architecture of this kind of protective protein. Their findings, which are published online in the current early edition of PNAS (Proceedings of the National Academy of Sciences), shed new light on the work of these proteins and may be able to help in the development of new treatments.

Cells have a variety of protein complexes that manage vital tasks. The functions of these "molecular machines" depend largely on their three-dimensional structure. In the first instance, proteins are long chains of amino acids, like a long piece of woolen thread. So-called chaperones help them to fold in the desired three-dimensional form after their production. If this folding process fails, the protein thread becomes an inextricable, useless tangle.

Small heat shock proteins (sHsps) are a particularly important group of chaperones. They prevent the clumping of proteins under stress conditions. αB-crystallin and the related sHsp αA-crystallin are the main representatives of the sHsps found in humans. Whereas αA-crystallin mainly occurs in the eye lens, αB-crystallin is also very common in the brain and in the heart and muscle tissue. In the eye lens, they counteract diseases like cataracts. Malfunctions of the αB-crystallin in tissue cells can give rise to cancer and neurological defects, including Alzheimer's disease.

Many research groups have focused their work on the α-crystallins due to their medical relevance. Despite intensive efforts, up to now, none of them have managed to determine the molecular architecture of these proteins
'/>"/>

Contact: Patrick Regan
regan@zv.tum.de
49-892-892-2743
Technische Universitaet Muenchen
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Structure of 450 million year old protein reveals evolutions steps
2. Scientists retrace evolution with first atomic structure of an ancient protein
3. A step toward tissue-engineered heart structures for children
4. Scientists learn structure of enzyme in unusual virus
5. Using nanotubes to detect and repair cracks in aircraft wings, other structures
6. Unveiling the structure of microcrystals
7. Why do males and females frequently differ in body size and structure?
8. Biopharmaceutical infrastructure key to lower drug development costs
9. First high-res 3D structures of mammalian HSP90 protein solved
10. New research on structure of bones raises questions for treatment of osteoporosis
11. Scientists unveil structure of molecular target of many drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Structure of protective protein in the eye lens revealed
(Date:7/9/2014)... be able to cope with the rising salinity of Arctic ... today is best known for its tundra and polar bear ... 38 million years ago during what is known as the ... temperate forest with brackish water, home to a variety of ... giant tortoises. Much of what is known about the region ...
(Date:7/9/2014)... pain and fever but often can be defeated with antibiotics ... hard to beat. Now, scientists have built a new weapon ... Published in the journal ACS Applied Materials & Interfaces ... kill more of them than medicine alone. , David Leong, ... lie in wait, undetectable in the human body or in ...
(Date:7/9/2014)... sparrow-sized fossil from China challenges the commonly held belief ... the ability to fly. The birdlike fossil is actually ... the remains of a tiny tree-climbing animal that could ... Museum in Blanding, Utah, and Alan Feduccia of the ... Journal of Ornithology . , The fossil of ...
Breaking Biology News(10 mins):Shark teeth analysis provides detailed new look at Arctic climate change 2Shark teeth analysis provides detailed new look at Arctic climate change 3Researchers declassify dinosaurs as being the great-great-grandparents of birds 2
... , WALL, N.J., Dec. 3 ... in wireless public safety and finger-based biometric identification solutions, ... Special Shareholder Meeting held today approved the sale of ... Inc. Of the shares voted, 98.6% were cast in ...
... Preliminary Press Conference Topics Last Call! Press ... Attention PIOs: Sending Press Releases to Fall meeting ... News Media registration information News Media Registration ... coming For important information regarding visas ...
... Have you ever felt overly upset by a social ... Scientists have long known that opium-like painkillers, called opioids, ... emotional stress. Now, a new study reviewed by Faculty of ... in the gene for the opioid receptor can determine the ...
Cached Biology News:BIO-key(R) Shareholders Overwhelmingly Approve Sale of Law Enforcement Division 2BIO-key(R) Shareholders Overwhelmingly Approve Sale of Law Enforcement Division 3AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 2AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 3AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 4AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 5AGU fall meeting: Preliminary press conference topics, press pre-registration deadline 6
(Date:1/15/2014)... This webinar will focus on EMA ... assessment in biosimilars. , Regulatory frameworks are evolving many ... however the complex nature of biopharmaceuticals makes the demonstration ... extremely challenging. Based on the specific aspects of biosimilar ...
(Date:1/15/2014)... More than 5 million Americans are ... 3 seniors will die with Alzheimer’s or another dementia, ... have shocked many Americans into looking for ways to ... tragic age-related cognitive disorders. Jonathan Weisman, president of Biohack ...
(Date:1/15/2014)... January 15, 2014 The Microcompetition with Foreign ... disease. One of these latent viruses is the Epstein Barr ... (RA). Rheumatoid arthritis (RA) is a chronic inflammatory disease that ... study found that RA patients have high concentrations of EBV ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... BNVI ) will present findings on the mechanism ... BN108 at the American Association of,Cancer Research (AACR) being ... CA, April 12 - 16, 2008., Bionovo,s poster ... death) induced by BN107 and BN108. As explained by ...
... Announces Change to Unaudited Financial Results Released March 18, ... ... Bulletin Board: NGNM) announced today that it had filed with the,Securities and Exchange ... A copy of this annual report can be found at, http://www.SEC.gov ., ...
... researchers at ... with internal solutions, REDWOOD CITY, Calif., April 15 ... life science researchers, and,Pfizer Pharmaceuticals, Inc. (NYSE: PFE ... a strategic,partnership today. This new multi-year partnership promotes enterprise-wide,deployment ...
Cached Biology Technology:Bionovo to Present Recent Findings of BN107 and BN108, Its Anticancer Agents, at the American Association of Cancer Research 2NeoGenomics Files Annual Report on Form 10-KSB with the SEC 2Ingenuity Systems and Pfizer Announce Strategic Partnership for Pathway Analysis 2Ingenuity Systems and Pfizer Announce Strategic Partnership for Pathway Analysis 3
Request Info...
... from E. coli is a ... also contains both 5'--3'and 3'--5' ... activity enables the enzyme to ... the DNA as starting points ...
Request Info...
... E. coli containing a clone of the human ... Topoisomerase II alters the topological state of nucleic ... a transient break which generates a separate DNA ... double-stranded DNA passage mechanism, the enzyme can relax ...
Biology Products: