Navigation Links
Structure of insulin's docking point identified
Date:3/24/2010

Walter and Eliza Hall Institute scientists have determined the structure of a previously unseen part of the insulin receptor, making possible new treatments for diabetes.

The insulin receptor is a large protein on the surface of cells to which the hormone insulin binds. Insulin controls when and how glucose is used in the human body. Understanding how insulin interacts with the insulin receptor is crucial to the development of treatments for diabetes.

Australian scientists revealed the structure of the major part of the insulin receptor in 2006 but the structure of a key segment to which insulin binds remained elusive. Now, Drs Mike Lawrence, Brian Smith, John Menting, Geoffrey Kong and Colin Ward from the institute's Structural Biology division, together with colleagues from the Case Western Reserve University and the University of Chicago, have worked out the molecular structure of this previously unseen region.

Their findings have been published today in the Proceedings of the National Academy of Sciences USA early edition.

Dr Lawrence said scientists had been trying for decades to work out how insulin interacts with the insulin receptor. "You can't work it out unless you have a view of the site to which the insulin binds, and that's what we've done," he said.

"By understanding how insulin binds and transmits messages into the cell we will be in a better position to design compounds that mimic insulin and could be used to treat diabetes."

As well as determining the three-dimensional structure of the insulin receptor, the team is also trying to work out the structure of the related Type 1 insulin-like growth factor receptor, to which insulin-like growth factors bind.

"These structures are not currently known, despite their considerable importance and direct relevance to the design of new drugs for cancer, Alzheimer's disease and diabetes - three of the most critical diseases facing Australia," Dr Lawrence said.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. Structure of 450 million year old protein reveals evolutions steps
2. Scientists retrace evolution with first atomic structure of an ancient protein
3. A step toward tissue-engineered heart structures for children
4. Scientists learn structure of enzyme in unusual virus
5. Using nanotubes to detect and repair cracks in aircraft wings, other structures
6. Unveiling the structure of microcrystals
7. Why do males and females frequently differ in body size and structure?
8. Biopharmaceutical infrastructure key to lower drug development costs
9. First high-res 3D structures of mammalian HSP90 protein solved
10. New research on structure of bones raises questions for treatment of osteoporosis
11. Scientists unveil structure of molecular target of many drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Structure of insulin's docking point identified
(Date:6/2/2016)... The Department of Transport Management (DOTM) ... million US Dollar project, for the , Supply ... Enrolment, and IT Infrastructure , to ... implementation of Identity Management Solutions. Numerous renowned international vendors participated ... was selected for the most compliant and innovative ...
(Date:6/1/2016)... 1, 2016 Favorable Government Initiatives ... and Criminal Identification to Boost Global Biometrics System Market ... TechSci Research report, " Global Biometrics Market By ... and Opportunities, 2011 - 2021", the global biometrics market ... on account of growing security concerns across various end ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... PHILADELPHIA , June 27, 2016  Liquid ... today announced the funding of a Sponsored Research ... study circulating tumor cells (CTCs) from cancer patients.  ... changes in CTC levels correlate with clinical outcomes ... therapies. These data will then be employed to ...
(Date:6/24/2016)... ... 24, 2016 , ... While the majority of commercial spectrophotometers and fluorometers use ... 6000i models are higher end machines that use the more unconventional z-dimension of 20mm. ... from the bottom of the cuvette holder. , FireflySci has developed several Agilent ...
(Date:6/23/2016)... CAMBRIDGE, Mass. , June 23, 2016 /PRNewswire/ ... the development of novel compounds designed to target ... compound, napabucasin, has been granted Orphan Drug Designation ... in the treatment of gastric cancer, including gastroesophageal ... cancer stemness inhibitor designed to inhibit cancer stemness ...
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
Breaking Biology Technology: