Navigation Links
Structure of insulin's docking point identified
Date:3/24/2010

Walter and Eliza Hall Institute scientists have determined the structure of a previously unseen part of the insulin receptor, making possible new treatments for diabetes.

The insulin receptor is a large protein on the surface of cells to which the hormone insulin binds. Insulin controls when and how glucose is used in the human body. Understanding how insulin interacts with the insulin receptor is crucial to the development of treatments for diabetes.

Australian scientists revealed the structure of the major part of the insulin receptor in 2006 but the structure of a key segment to which insulin binds remained elusive. Now, Drs Mike Lawrence, Brian Smith, John Menting, Geoffrey Kong and Colin Ward from the institute's Structural Biology division, together with colleagues from the Case Western Reserve University and the University of Chicago, have worked out the molecular structure of this previously unseen region.

Their findings have been published today in the Proceedings of the National Academy of Sciences USA early edition.

Dr Lawrence said scientists had been trying for decades to work out how insulin interacts with the insulin receptor. "You can't work it out unless you have a view of the site to which the insulin binds, and that's what we've done," he said.

"By understanding how insulin binds and transmits messages into the cell we will be in a better position to design compounds that mimic insulin and could be used to treat diabetes."

As well as determining the three-dimensional structure of the insulin receptor, the team is also trying to work out the structure of the related Type 1 insulin-like growth factor receptor, to which insulin-like growth factors bind.

"These structures are not currently known, despite their considerable importance and direct relevance to the design of new drugs for cancer, Alzheimer's disease and diabetes - three of the most critical diseases facing Australia," Dr Lawrence said.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. Structure of 450 million year old protein reveals evolutions steps
2. Scientists retrace evolution with first atomic structure of an ancient protein
3. A step toward tissue-engineered heart structures for children
4. Scientists learn structure of enzyme in unusual virus
5. Using nanotubes to detect and repair cracks in aircraft wings, other structures
6. Unveiling the structure of microcrystals
7. Why do males and females frequently differ in body size and structure?
8. Biopharmaceutical infrastructure key to lower drug development costs
9. First high-res 3D structures of mammalian HSP90 protein solved
10. New research on structure of bones raises questions for treatment of osteoporosis
11. Scientists unveil structure of molecular target of many drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Structure of insulin's docking point identified
(Date:6/14/2017)... (NYSE: IBM ) is introducing several innovative partner startups ... collaboration between startups and global businesses, taking place in ... nine startups will showcase the solutions they have built with ... France is one of the ... percent increase in the number of startups created between 2012 ...
(Date:5/16/2017)... , May 16, 2017   Bridge ... health organizations, and MD EMR Systems , ... development partner for GE, have established a partnership ... Portal product and the GE Centricity™ products, including ... EMR. These new integrations will ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
Breaking Biology News(10 mins):
(Date:6/28/2017)... ... ... Studies indicate that replacing damaged brain cells with those derived from human embryonic ... not been determined is the optimal stage during differentiation of the stem cells that ... coming out of Singapore, recently published in STEM CELLS Translational Medicine journal may provide ...
(Date:6/27/2017)... ... June 27, 2017 , ... Indiana-based Xylogenics announced today ... and fermentation process. The efficiencies created by the newest strain design will ... the ethanol industry wherein individual production plants are planning to invest upwards of ...
(Date:6/26/2017)... Philadelphia, PA (PRWEB) , ... June 26, 2017 , ... ... at its annual Shareholders Meeting on June 9, 2017: Jeremy Nowak, President, J Nowak ... The Science Center also announced the election of Glen N. Gaulton and Kenneth L. ...
(Date:6/23/2017)... ... June 23, 2017 , ... The Academy of ... the University Aviation Association (UAA), the unifying voice for collegiate aviation education, are ... encourage teamwork, competition, and success through a STEM-based education platform. , Much like ...
Breaking Biology Technology: