Navigation Links
Structure of insulin's docking point identified
Date:3/24/2010

Walter and Eliza Hall Institute scientists have determined the structure of a previously unseen part of the insulin receptor, making possible new treatments for diabetes.

The insulin receptor is a large protein on the surface of cells to which the hormone insulin binds. Insulin controls when and how glucose is used in the human body. Understanding how insulin interacts with the insulin receptor is crucial to the development of treatments for diabetes.

Australian scientists revealed the structure of the major part of the insulin receptor in 2006 but the structure of a key segment to which insulin binds remained elusive. Now, Drs Mike Lawrence, Brian Smith, John Menting, Geoffrey Kong and Colin Ward from the institute's Structural Biology division, together with colleagues from the Case Western Reserve University and the University of Chicago, have worked out the molecular structure of this previously unseen region.

Their findings have been published today in the Proceedings of the National Academy of Sciences USA early edition.

Dr Lawrence said scientists had been trying for decades to work out how insulin interacts with the insulin receptor. "You can't work it out unless you have a view of the site to which the insulin binds, and that's what we've done," he said.

"By understanding how insulin binds and transmits messages into the cell we will be in a better position to design compounds that mimic insulin and could be used to treat diabetes."

As well as determining the three-dimensional structure of the insulin receptor, the team is also trying to work out the structure of the related Type 1 insulin-like growth factor receptor, to which insulin-like growth factors bind.

"These structures are not currently known, despite their considerable importance and direct relevance to the design of new drugs for cancer, Alzheimer's disease and diabetes - three of the most critical diseases facing Australia," Dr Lawrence said.


'/>"/>

Contact: Penny Fannin
fannin@wehi.edu.au
61-393-452-345
Walter and Eliza Hall Institute
Source:Eurekalert  

Related biology news :

1. Structure of 450 million year old protein reveals evolutions steps
2. Scientists retrace evolution with first atomic structure of an ancient protein
3. A step toward tissue-engineered heart structures for children
4. Scientists learn structure of enzyme in unusual virus
5. Using nanotubes to detect and repair cracks in aircraft wings, other structures
6. Unveiling the structure of microcrystals
7. Why do males and females frequently differ in body size and structure?
8. Biopharmaceutical infrastructure key to lower drug development costs
9. First high-res 3D structures of mammalian HSP90 protein solved
10. New research on structure of bones raises questions for treatment of osteoporosis
11. Scientists unveil structure of molecular target of many drugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Structure of insulin's docking point identified
(Date:2/2/2017)... , Feb. 2, 2017  EyeLock LLC, a market ... new white paper " What You Should Know About ... of ensuring user authenticity is a growing concern. In ... of users. However, traditional authentication schemes such as username/password ... Biometric authentication offers an elegant solution to the ...
(Date:2/1/2017)... IDTechEx Research, a leading provider of independent ... availability of a new report, Sensors for Robotics: Technologies, Markets ... ... ... IDTechEx Report "Sensors for Robotics: Technologies, Markets and Forecasts 2017-2027: Machine ...
(Date:1/30/2017)... , Jan. 30, 2017   Invitae Corporation ... fastest growing genetic information companies, today announced that it ... results and provide 2017 guidance on Monday, February 13, ... call that day at 4:45 p.m. Eastern / 1:45 ... management team will briefly review financial results, guidance, and ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... , February 17, 2017 ... Market by Product (Consumables, Service), Type (Safety, Efficacy, ... Development, Drug Discovery and Development, Disease-Risk) - Global ... is projected to reach USD 53.34 Billion by ... at a CAGR of 13.8% during the forecast ...
(Date:2/16/2017)... ... ... EIT Digital has launched work to develop a new Smart IOT ... to get under way for the framework, which is designed to reduce the use ... to be transferred eventually to other industries that also require efficient IoT and management ...
(Date:2/16/2017)... 16, 2017  ArmaGen, Inc., a privately held ... treat severe neurological disorders, today reported preliminary evidence ... the company,s investigational therapy for the treatment of ... type I, or MPS I). The initial results ... presented today at the 13 th annual ...
(Date:2/16/2017)... , Feb. 16, 2017 UCHealth ( ... to utilize LungDirect for pulmonary nodule patient management. In ... nodule, or a spot on the lung, UCHealth looks ... on manual data entry. Stephanie Brown, ... tracking my nodule patients with an Excel spreadsheet, which ...
Breaking Biology Technology: