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Structure of enzyme against chemical warfare agents determined
Date:1/28/2009

yield complementary information about a protein structure. This information about hydrogen atoms is therefore essential for a basic understanding of the reaction mechanism of DFPase.

Neutron structures of proteins are quite rare and technically demanding, requiring large crystals and long measurement times. Though the first neutron structure of a protein was reported 40 years ago, in 1969, to date only about 20 unique structures have been solved, out of 50000 entries in the Protein Data Bank. " The effort has been absolutely worth it, " says Junior-Prof. Julian Chen, who published this work together with Dr. Marc-Michael Blum and Prof. Heinz Rueterjans. " Based on the results of this study, we can now create targeted changes to DFPase to augment the activity, as well as diversify the substrate range of the enzyme."


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Contact: Julian Chen
chen@chemie.uni-frankfurt.de
49-697-982-9641
Goethe University Frankfurt
Source:Eurekalert

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