Navigation Links
Structure of cell signaling molecule suggests general on-off switch
Date:4/21/2013

DURHAM, N.C. A three-dimensional image of one of the proteins that serves as an on-off switch as it binds to receptors on the surface of a cell suggests there may be a sort of main power switch that could be tripped. These surface receptors are responsible for helping cells discern light, set the heart racing, or detect pain.

The finding, published online April 21, 2013, in the journal Nature by a research collaboration involving this year's Nobel laureates in chemistry, could help in the development of more effective drugs to switch on or off the cell receptors that regulate nearly every bodily function. Already, up to half of all drugs engage these receptors, including antihistamines and beta blockers, but many of the intricacies of how these important proteins work remain unknown.

"It's important to understand how this extraordinary family of receptors work," said co-author Robert J. Lefkowitz, M.D., James B. Duke Professor of Medicine and Howard Hughes Medical Institute Investigator. "This is the kind of finding that answers a basic curiosity, but can also be of benefit if we can develop new drugs or improve the ones we have."

The research marks a collaborative reunion between Lefkowitz and Brian K. Kobilka, M.D., chair of molecular and cellular physiology at Stanford University School of Medicine. The two researchers friends who first collaborated when Kobilka was a trainee in Lefkowitz's laboratory at Duke - shared the 2012 Nobel Prize in Chemistry for their discoveries involving the G-protein coupled receptors (GPCRs), which are activated by signaling proteins to detect hormones, neurotransmitters, pain, light.

In the current work, the researchers used X-ray crystallography to develop an atom-scale image of one of the principal signaling molecules that regulate GPCRs. This protein is called beta-arrestin1, which, among other things, works to dim a cell's response to hormones such as adrenalin.

The r
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
2. Mainz scientists confirm original tetrahedral model of the molecular structure of water
3. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
4. Newly discovered plant structure may lead to improved biofuel processing
5. Nanostructures with living cells
6. Protein structure: Immune system foiled by a hairpin
7. Novel technique reveals dynamics of telomere DNA structure
8. Scientists discover structure of protein essential for quality control, nerve function
9. Banded mongooses structure monosyllabic sounds in a similar way to humans
10. New study defines the long-sought structure of a protein necessary for cell-cell interaction
11. Nanoengineers can print 3D microstructures in mere seconds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/12/2015)... , March 12, 2015 ... a standardized identity and access management (IAM) solution ... implementation schedule. With Beta System,s new IAM package, ... best practices gleaned from multiple IAM implementations across ... the software as well as any necessary services ...
(Date:3/11/2015)... 11, 2015   The Sync Project™ ... scientifically measure and harness music to improve health. ... and objective measurements of physiology, enabling the study ... in large populations. It is designed for medical ... perform rigorous studies and accelerate the discovery of ...
(Date:3/10/2015)... 10, 2015   Tute Genomics , pioneer in ... by next-generation sequencing company PrimBio Research Institute ... targeted gene panel interpretation. PrimBio, a certified ... most current technologies to support the work of experts ... offers two types of exome sequencing services: 1) Targeted ...
Breaking Biology News(10 mins):Beta Systems Fast Forward IAM Available Now: a Standardized IAM Package at a Fixed Price 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 2Introducing The Sync Project, a Global Collaboration Harnessing the Scientific Potential of Music for Health 3PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 2PrimBio Research Selects Tute as Whole Exome Analysis Provider, Creating Integrated, End-to-End Solution for Next-Generation Sequencing & Data Analysis 3
... GAINESVILLE, Fla. You might not know what it,s ... especially after an accident, it is likely you have ... a patient,s throat to prevent regurgitation and spilling of ... is being administered. Such regurgitation could result in ...
... Two experimental treatments, a retinal prosthesis and fetal tissue ... diseases. The findings, presented at Neuroscience 2009, the annual ... largest source of emerging news on brain science and ... Researchers also reported that an engineered protein restored vision ...
... 2009 New research focused on the quality ... as increasingly popular botanicals is being sponsored by ... Fellowship Program. USP fellowships are awarded to graduate ... care/scientific doctoral or post-doctoral programs to support research ...
Cached Biology News:UF scientists discover new explanation for controversial old patient-care technique 2UF scientists discover new explanation for controversial old patient-care technique 3Experimental treatments restore partial vision to blind people 2New research examining essential drugs, emerging botanicals supported by USP Awards 2New research examining essential drugs, emerging botanicals supported by USP Awards 3
(Date:4/1/2015)... 2015  VLP Therapeutics, LLC. ("VLP"), a ... and development of therapeutic and preventative vaccines and next ... vaccine technology, today announced that it has entered into a ... Nagasaki University in ... and development of dengue vaccine candidates. ...
(Date:4/1/2015)... -- Goldman Small Cap Research, a stock market research ... announced today that it has issued a new article ... traded clinical stage biotechnology company focused on developing and ... sponsored research article, along with disclosures and disclaimers, or ... www.GoldmanResearch.com .  In the article on ...
(Date:4/1/2015)... , April 1, 2015  EMD Serono, the U.S. ... , announced today the appointment of Frederick ... Neurology and Immunology. In this capacity, he will lead ... development projects and collaborations for Rebif ® (interferon ... pipeline. Dr. Munschauer joins EMD Serono ...
(Date:4/1/2015)... DUBLIN , Mar. 30, 2015 Research ... announced the addition of the "Blood Screening ... Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western ... Bank, Hospital) - Forecasts to 2019 " ... screening market is expected to reach $2.55 billion ...
Breaking Biology Technology:VLP Therapeutics Enters Collaboration with Institute of Tropical Medicine, Nagasaki University 2VLP Therapeutics Enters Collaboration with Institute of Tropical Medicine, Nagasaki University 3Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 2Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 3Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 4EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 2EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 3EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 4EMD Serono Appoints Frederick E. Munschauer M.D., FAAN to Vice President of Medical Affairs, Neurology and Immunology 5Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 2Global Blood Screening (Nucleic Acid Amplification Test, ELISA, Rapid Test, Chemiluminescence Immunoassay, Next Generation Sequencing, Western Blotting) Market 2015-2019 3
... May 18 Dr. Jonathan M. Rothberg , chairman, CEO ... winner of the Connecticut Medal of Technology for his development of innovative genomic ... Dr. Rothberg is the founder ... has dedicated his life to developing sequencing technology that will help improve the ...
... , ... wastes has never been easier, or less smelly, thanks to a new indoor composting ... composting bucket collects food scraps in an airtight bucket. Bokashi, made using SCD,s probiotic ... , ...
... SANTA BARBARA, Calif. , May 17 Abviva, ... development and commercialization of breast cancer related applications of Mammastatin, ... on the core technology that may be used for therapeutic ... the Mammastatin Serum Assay (MSA). The patents are the most ...
Cached Biology Technology:Genetics Entrepreneur Jonathan Rothberg Wins CT Medal of Technology 2All Seasons Indoor Composter™ and All Seasons Bokashi™ Provide Easy Way to Recycle Food Waste Right in Your Kitchen 2All Seasons Indoor Composter™ and All Seasons Bokashi™ Provide Easy Way to Recycle Food Waste Right in Your Kitchen 3Abviva Announces Further Patent Issuance for Technology Used in Breast Cancer Diagnostics and Therapeutics 2Abviva Announces Further Patent Issuance for Technology Used in Breast Cancer Diagnostics and Therapeutics 3
kismet (dK-20)...
... Centra CL3 series is designed to ... and clinical applications at a reasonable ... includes quick connect rotors and various ... intuitive interface allows you to control ...
PP2B-Abeta (C-20)...
DNA Polymerase I Large (Klenow) Fragment is a DNA polymerase that lacks the 5'Cut Site3' exodeoxyribonuclease activity of intact DNA Polymerase I but it contains the 3'Cut Site5' exodeoxyribonuclease...
Biology Products: