Navigation Links
Structure of cell signaling molecule suggests general on-off switch
Date:4/21/2013

DURHAM, N.C. A three-dimensional image of one of the proteins that serves as an on-off switch as it binds to receptors on the surface of a cell suggests there may be a sort of main power switch that could be tripped. These surface receptors are responsible for helping cells discern light, set the heart racing, or detect pain.

The finding, published online April 21, 2013, in the journal Nature by a research collaboration involving this year's Nobel laureates in chemistry, could help in the development of more effective drugs to switch on or off the cell receptors that regulate nearly every bodily function. Already, up to half of all drugs engage these receptors, including antihistamines and beta blockers, but many of the intricacies of how these important proteins work remain unknown.

"It's important to understand how this extraordinary family of receptors work," said co-author Robert J. Lefkowitz, M.D., James B. Duke Professor of Medicine and Howard Hughes Medical Institute Investigator. "This is the kind of finding that answers a basic curiosity, but can also be of benefit if we can develop new drugs or improve the ones we have."

The research marks a collaborative reunion between Lefkowitz and Brian K. Kobilka, M.D., chair of molecular and cellular physiology at Stanford University School of Medicine. The two researchers friends who first collaborated when Kobilka was a trainee in Lefkowitz's laboratory at Duke - shared the 2012 Nobel Prize in Chemistry for their discoveries involving the G-protein coupled receptors (GPCRs), which are activated by signaling proteins to detect hormones, neurotransmitters, pain, light.

In the current work, the researchers used X-ray crystallography to develop an atom-scale image of one of the principal signaling molecules that regulate GPCRs. This protein is called beta-arrestin1, which, among other things, works to dim a cell's response to hormones such as adrenalin.

The r
'/>"/>

Contact: Sarah Avery
sarah.avery@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study led by NUS researchers proves the existence of 3 overstretched DNA structures
2. Mainz scientists confirm original tetrahedral model of the molecular structure of water
3. A*STAR scientists groundbreaking discovery of nucleus structure crucial to understanding diseases
4. Newly discovered plant structure may lead to improved biofuel processing
5. Nanostructures with living cells
6. Protein structure: Immune system foiled by a hairpin
7. Novel technique reveals dynamics of telomere DNA structure
8. Scientists discover structure of protein essential for quality control, nerve function
9. Banded mongooses structure monosyllabic sounds in a similar way to humans
10. New study defines the long-sought structure of a protein necessary for cell-cell interaction
11. Nanoengineers can print 3D microstructures in mere seconds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... 2015 Huntington Memorial Hospital is the first ... new miniaturized, wireless monitoring sensor to manage heart failure ... only FDA-approved heart failure monitoring device that has been ... physicians to manage heart failure. The CardioMEMS ... the pulmonary artery (PA) during a non-surgical procedure to ...
(Date:4/14/2015)... April 14, 2015  HYPR Corp. today announced ... ® ) Alliance tm , an industry consortium ... commit to share technology and collaborate to deliver ... interoperable, more secure and private, and easier to ... verification that protects sensitive user information and eliminates ...
(Date:4/13/2015)... 2015  higi, a leading cloud-based consumer engagement platform ... engage with their communities around health and wellness, announced ... secure API.  ... affordable, and convenient vehicle to receive validated health information ... The API will allow higi,s trusted partners, on ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... used an innovative inkjet system to print unique "bio-ink" ... to differentiate into both muscle cells and bone cells. ... system that can pattern the formation of multiple tissues ... , Bioengineers from Carnegie Mellon University’s Robotics Institute ...
... have discovered a better way to see where a drug ... novel hollow platinum nanostructures. , The research will appear as ... journal Angewandte Chemie Int. Ed. In advance of publication, it ... web site. , Sandia is a National Nuclear Security ...
... by researchers at the University at Buffalo has been shown ... tumors and to inhibit the cancer's spread to the lungs ... antibody, named JAA-F11, targets a particular disaccharide, an antigen known ... cancer cells. While the antibody did not kill the ...
Cached Biology News:Muscle and bone from an ink-jet printer 2Sandia researchers discover way to see how a drug attaches to a cell 2Antibody extends life of mice with breast cancer 2
(Date:4/24/2015)... 2015 Leading Regenerative Veterinary Medicine ... allogeneic stem-cell product development program and changes its’ ... corporate strategic direction. , “I am extremely pleased ... cell development program has been kicked into high ... facility and hiring of our new Director of ...
(Date:4/24/2015)... Telbec/ - Mirego, leader in mobile strategies and solutions, is ... app extensions for the all new Apple Watch. Made in ... and MediaMiser, these extensions will reinvent the way users receive ... wrist use.  Available today in ... tactile smartwatch that makes for an excellent buddy for business, ...
(Date:4/23/2015)... Marshall, MN (PRWEB) April 24, 2015 ... agreement with Advanced Birthright Nutrition® (ABN) for the exclusive ... Milk Cup. The new technology is a new in-line ... swine producers by allowing them to move supplementation milk ... running. , “This technology lets producers get ...
(Date:4/23/2015)... , April 23, 2015 BioTE Medical President ... book "Age Healthier Live Happier - Avoiding Over-Medication through ... Age Management Medicine Group Conference at JW Marriott / ... ",Age Healthier Live Happier, is a welcomed ... over-medication and searching for a higher quality of life ...
Breaking Biology Technology:Vet-Stem, Inc. Meets New Milestones and Changes Name to VetStem Biopharma 2Familiprix, OMSignal and MediaMiser apps available today for Apple Watch 2Ralco Acquires License to Birthright™ Moveable Milk Cup 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3
... and SHP Parakrama Karunaratne, Dept. of Medical,Parasitology, London School of Hygiene and Tropical Medicine, ... , Introduction , ... a worldwide vector of , diseases such ... are sprayed with organophosphate insecticides. However, mosquitoes develop , ...
... Brian J. Shiell and Wojtek P. Michalski, CSIRO Division of ... , Introduction ... composition analyses of proteins can be performed , ... the most commonly used method of recovering proteins from gels, can ...
... and William S. Dalton,H. Lee Moffitt Cancer Center and Research Institute, University of ... , ... mutations within specific genes has become an important , ... , including cancer. Several techniques have ...
Cached Biology Technology:Preparative Nondenaturing Gel Electrophoresis Used in the Purification of an Esterase Involved in Insecticide Resistance, Rev C 2Preparative Nondenaturing Gel Electrophoresis Used in the Purification of an Esterase Involved in Insecticide Resistance, Rev C 3Fractionation of Bovicola ovis Homogenates Using the Mini Whole Gel Eluter 2Fractionation of Bovicola ovis Homogenates Using the Mini Whole Gel Eluter 3Detection of Mutations in the Fas Antigen of Lymphoma Tumors by RT-PCR and Denaturing Gradient Gel Electrophoresis 2Detection of Mutations in the Fas Antigen of Lymphoma Tumors by RT-PCR and Denaturing Gradient Gel Electrophoresis 3Detection of Mutations in the Fas Antigen of Lymphoma Tumors by RT-PCR and Denaturing Gradient Gel Electrophoresis 4Detection of Mutations in the Fas Antigen of Lymphoma Tumors by RT-PCR and Denaturing Gradient Gel Electrophoresis 5
... Ingredients (g/L):,Tryptone, 10 ,Yeast extract, 5 ... 0.3 ,Ferric ammonium citrate, 0.5 ,IPTG, ... water soluble, autoclavable chromogenic substrate for ... by -galactosidase generates a black insoluble ...
... UNOsphere ion exchange ... supports with high binding ... support is a strong ... particle size of 120 ...
...
... Polyclonal Antibody against Aph-1a (Aph-1aL,S ... The gamma secretase is a multiprotein ... and Pen-2; all four proteins are ... gamma secretase complex catalyzes cleavage of ...
Biology Products: