Navigation Links
Structure of a protein related to heart and nervous system health revealed
Date:11/16/2010

ANN ARBOR, Mich. -- University of Michigan researchers have solved the structure of a protein that is integral to processes responsible for maintaining a healthy heart and nervous system.

The protein structure in question is cystathionine beta-synthase, known as CBS. CBS uses vitamin B6 to make hydrogen sulfide (H2S), a gaseous signaling molecule that helps maintain a healthy heart and nervous system. H2S also induces a state of suspended animation or hibernation in animals by decreasing body temperature and lowering metabolic rate.

The work to decode the structure was led by Ruma Banerjee, Ph.D., a professor in the Department of Biological Chemistry at the U-M Medical Schoool, Janet Smith, Ph.D., a research professor at the U-M Life Sciences Institute, and their colleagues. Their findings are published today in the Proceedings of the National Academy of Sciences.

"The structure of full-length CBS, which has eluded the science community for more than a decade, provides a wealth of new information about gas generation by CBS, which is especially important in the brain," says Banerjee, the study's senior author and the Vincent Massey Collegiate Professor of Biological Chemistry and associate chair of biological chemistry . "It also provides a framework for understanding homocystinuria-causing mutations."

Mutations in the gene for CBS cause homocystinuria, an inherited disorder that affects the central nervous system, ocular, skeletal, and cardiovascular systems.

The structure of the full-length CBS, seen here for the first time, provides a molecular explanation for homocystinuria due to CBS defects.

The activity of CBS is increased by SAMe (S-adenosylmethionine), a dietary supplement that is used for its anti-depressant and anti-inflammatory activities. SAMe also increases production of H2S by binding to CBS.

"Molecular insights into the architecture of the CBS domain to which SAMe binds open doors to rational drug design for fine-tuning H2S production for pharmaceutical purposes," says colleague Markos Koutmos, Ph.D., a research investigator in Smith's research group .

"We captured the CBS enzyme at two points in its complex chemical reaction by trapping two highly reactive chemical intermediates in the active site of the enzyme," says researcher Omer Kabil, Ph.D., a postdoctoral fellow in Banerjee's lab. The structures of these trapped species reveal details of how vitamin B6 helps CBS perform the complex chemical reactions leading to H2S production.

"The important chemical details we see in CBS can be applied to understanding the other human enzymes that depend on vitamin B6, of which there are more than 50," says Smith, who in addition to her LSI position is also the Martha L. Ludwig Professor of Protein Structure & Function in the Department of Biological Chemistry of the Medical School.


'/>"/>

Contact: Jennifer Farina
jrfarina@umich.edu
734-615-4862
University of Michigan Health System
Source:Eurekalert  

Related biology news :

1. Carbon nanostructures form the future of electronics and optoelectronics
2. Structures of important plant viruses determined
3. The structure of the Mre11 protein bound to DNA
4. Scripps research team solves structure of beneficial virus
5. Brain structure provides key to unraveling function of bizarre dinosaur crests
6. Key to function of dinosaur crests found in brain structure
7. How we see objects in depth: The brains code for 3-D structure
8. NSF funds research at Illinois on sustainable biofuels infrastructure
9. Biologists learn structure, mechanism of powerful molecular motor in virus
10. HWI scientist first in world to unravel structure of key breast cancer target enzyme
11. Brain structure assists in immune response, according to Penn vet study
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Structure of a protein related to heart and nervous system health revealed
(Date:4/13/2016)... , April 13, 2016  IMPOWER physicians supporting ... are setting a new clinical standard in telehealth thanks ... By leveraging the higi platform, IMPOWER patients can routinely ... pulse and body mass index, and, when they opt ... and convenient visit to a local retail location at ...
(Date:3/31/2016)... , March 31, 2016  Genomics firm Nabsys has ... CEO, Barrett Bready , M.D., who returned to ... the original technical leadership team, including Chief Technology Officer, ... Product Development, Steve Nurnberg and Vice President of Software ... the company. Dr. Bready served as CEO ...
(Date:3/23/2016)... WAKEFIELD, Massachusetts , March 23, 2016 ... kombiniert im Interesse erhöhter Sicherheit Gesichts- und ... Xura, Inc. (NASDAQ: MESG ... heute bekannt, dass das Unternehmen mit SpeechPro ... insbesondere aus der Finanzdienstleistungsbranche, wird die Möglichkeit ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the ... Convention Center and will showcase its product’s latest features from June 26 to ... a scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity ... intelligent tools designed, tuned and optimized exclusively for Okuma CNC machining centers at ... result of a collaboration among several companies with expertise in toolholding, cutting tools, ...
(Date:6/23/2016)... India , June 23, 2016 ... media market research report to its pharmaceuticals section ... profiles, product details and much more. ... spread across 151 pages, profiling 15 companies and ... available at http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . ...
(Date:6/22/2016)... , June 22, 2016 Research and ... Global Markets" report to their offering. ... billion in 2014 from $29.3 billion in 2013. The market is ... of 13.8% from 2015 to 2020, increasing from $50.6 billion in ... projected product forecasts during the forecast period (2015 to 2020) are ...
Breaking Biology Technology: