Navigation Links
Structure of 450 million year old protein reveals evolution's steps
Date:8/16/2007

otein via a large database of modern receptor genes. This earlier work, which compared the genetic similarities and differences among two of these modern genes, found the receptor descended from a single common genetic ancestor 450 million years ago. The researchers then recreated the ancient receptor in the laboratory.

Only seven mutations were needed to bridge the 450-million-year gulf, the researchers found. However, not every mutation changed the proteins function. These permissive mutations appear to pave the way for future, more significant changes. Its like they prepared for opportunity to knock in the form of a new hormone, Ortlund said.

The permissive mutations bolstered the receptors structure, like contractors reinforce a historic homes foundation before making renovations. After these changes took place, a more extreme mutation repositioned an entire group of atoms, bringing them closer to fitting the cortisol hormone. Another created the tight new fit with cortisol.

These permissive mutations are chance events. If they hadnt happened first, then the path to the new function could have become an evolutionary road not taken, said co-author John Thornton, a professor of evolutionary biology at the University of Oregon.

The researchers worked out which mutations came first by synthesizing different versions of the mutated protein in the laboratory. Had the radical mutations come first, the receptor protein would have lost its function entirely, they found.


'/>"/>

Contact: Becky Oskin
becky_oskin@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Man and mouse share genome structures
2. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
3. Scientists solve structure of key protein in innate immune response
4. Vascular structure and function improve with diet and exercise
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. SuperLigands - a database of ligand structures derived from the Protein Data Bank
7. Structure-building cell signals also may influence learning and memory
8. PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information
9. DNA constraints control structure of attached macromolecules
10. Scripps research scientists solve structure of a critical innate immune system protein
11. Major advance made on DNA structure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... larvae can swim up to 400 kilometres in search of ... environmental change. , Clownfish spend their entire adult lives under ... must wander the open ocean, says study co-author, Dr Hugo ... Studies (Coral CoE) at James Cook University. , "In the ... been given a rare glimpse into how far they can ...
(Date:9/17/2014)... Institute for the Arts and Humanities has received a ... a two-year project, "The Boundaries of the Human in ... will support a wide-ranging series of events aimed at ... One involves artists and researchers who are exploring the ... idea of humanism, and the other involves the increasingly ...
(Date:9/17/2014)... -- "Nature has developed, very cleverly, some lessons on ... optical design," said Joseph Shaw, director of the Optical ... surfaces and structures at the nanoscale, we,ll discover them." ... Diego in August during a conference called "The Nature ... Rongguang Liang of the University of Arizona College of ...
Breaking Biology News(10 mins):Nemo's epic journey to find a new home 2Mellon Foundation awards grant for major project in the humanities and sciences 2Nature's designs inspire research into new light-based technologies 2Nature's designs inspire research into new light-based technologies 3
... by a team of researchers led by Jeffrey Peng, ... of Notre Dame, is using Nuclear Magnetic Resonance (NMR), ... dynamic flexibility of drugs and their targets. The ... American Chemical Society, contributes to the growing attention given ...
... Spanish . , Researchers at the Centre ... the Universidad de Kentucky (USA), have discovered a new way ... pathogen agents responsible for transmissible spongiform encephalopathies or TSEs) by ... control prion disease in deer, which has become an epidemic ...
... Swedish medical university Karolinska Institutet presents a new technique ... the first time. By examining people who had received ... that in all cases there were traces of amphetamine ... tests have been carried out using urine and blood ...
Cached Biology News:Nuclear magnetic resonance aids in drug design 2Researchers embark on work to control the prion epidemic affecting deer in the USA 2Researchers embark on work to control the prion epidemic affecting deer in the USA 3New technique enables drug tests via exhaled breath 2
(Date:9/18/2014)... DUBLIN, Ireland , September 18, ... ,Research and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) ... "Biocompatible Materials - Global Strategic ... offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report ... Materials in US$ Million by the ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... Albumin Industry Report 2014" report to their offering. ... 2014 is a professional and in-depth study on the ... The report provides a basic overview of the ... The human albumin market analysis is provided for the ...
(Date:9/18/2014)... , Sept. 18, 2014  Neogen Corporation (Nasdaq: ... entered into a strategic agreement with Merck Animal Health ... The Igenity Dairy Heifer Program consists ... information on the genetic potential of replacement dairy heifers. ... calf is born, and is an excellent tool in ...
(Date:9/18/2014)... 18, 2014 SeqLL Inc., the ... technology, announced today the closing of a $1M ... by Genomic Diagnostic Technologies, will increase the power ... , Founded in March 2013 by Daniel Jones, ... at Helicos BioSciences, SeqLL has continued to offer ...
Breaking Biology Technology:Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Merck Animal Health to market Neogen's dairy genomic program 2SeqLL Closes Series-A Funding Round for Expansion of Single Molecule Sequencing 2
... , , SAO PAULO , Feb. ... to postpone a decision to reduce Brazil,s ,ethanol import duty from ... to be announced, but not for its impact to take effect once ... it describes as little more than a "bureaucratic" delay. , ...
... , SAN FRANCISCO , ... a leader in Integrated Voice Response (IVR)/Integrated Web Response (IWR) ... allows users to design and deploy clinical trial Integrated Response ... of clinical trials. This time and cost savings stems from ...
... ... nematodes as the Divergence and National Corn Growers Association continues collaboration. , ... (PRWEB) February 9, 2010 -- ... Research (SBIR) grants totaling $500,000, along with renewed funding from the National Corn Growers ...
Cached Biology Technology:Brazilian Sugarcane Industry Association Stresses Need for Brazil's Government to Announce Ethanol Import Tariff Cut as Soon as Possible 2Brazilian Sugarcane Industry Association Stresses Need for Brazil's Government to Announce Ethanol Import Tariff Cut as Soon as Possible 3endpoint Saves Money and Time for Medical Research Teams Through PULSE 2endpoint Saves Money and Time for Medical Research Teams Through PULSE 3New Funding Validates Importance of Divergence's Work on Nematodes 2New Funding Validates Importance of Divergence's Work on Nematodes 3