Navigation Links
Structure of 450 million year old protein reveals evolution's steps
Date:8/16/2007

A detailed map that pinpoints the location of every atom in a 450-million-yeard-old resurrected protein reveals the precise evolutionary steps needed to create the molecules modern version, according to researchers from the University of North Carolina at Chapel Hill and the University of Oregon.

Until now, scientists trying to unravel the evolution of the proteins and other molecules necessary for life have worked backwards, making educated guesses based on modern human body chemistry. By moving forward from an ancient protein, the team laid out the step-by-step progression required to reach its current form and function.

The study appears in the Aug. 17, 2007, issue of the journal Science.

We were able to see exactly how mutations in the ancient structure led to the modern receptor, said lead author Eric Ortlund, who carried out the research as a UNC-Chapel Hill postdoctoral fellow. Ortlund is now an assistant professor of biochemistry in the Emory University School of Medicine.

In the current study, Ortlund and Matt Redinbo, a professor of chemistry, biochemistry and biophysics at UNC-Chapel Hill, generated a three-dimensional picture of the ancient receptor with an imaging technique called X-ray crystallography. The nanoscale image revealed the receptors structure, down to the placement of every atom. With the structure in place, Ortlund and his colleagues retraced evolutions path.

The researchers examined the precursor to a modern protein known as a glucocorticoid receptor. In humans, the receptor plays a crucial role, responding to the hormone cortisol and regulating the bodys stress response. The two receptor and hormone fit together as precisely as a lock and key. The precursor preferred a different hormone, so several mutations were necessary before the lock could fit the cortisol key.

The University of Oregon team, which included postdoctoral scientist Jamie Bridgham, resurrected the ancient pr
'/>"/>

Contact: Becky Oskin
becky_oskin@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Man and mouse share genome structures
2. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
3. Scientists solve structure of key protein in innate immune response
4. Vascular structure and function improve with diet and exercise
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. SuperLigands - a database of ligand structures derived from the Protein Data Bank
7. Structure-building cell signals also may influence learning and memory
8. PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information
9. DNA constraints control structure of attached macromolecules
10. Scripps research scientists solve structure of a critical innate immune system protein
11. Major advance made on DNA structure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... where electric cars ply silent freeways, solar panels blanket ... the earth, from howling winds and from the blazing ... it is technically and economically feasible to convert California,s ... energy. Published in Energy , the plan shows ... supply in California that could create tens of thousands ...
(Date:7/24/2014)... has developed a new nanoscale agent for imaging the ... the function and properties of the GI tract in ... of gut diseases. , Illnesses such as ... bowel disease all occur in the intestine and can ... such as diabetes and Parkinson,s. , Until now, ...
(Date:7/24/2014)... Environmental cleanup experts gathered at NJIT this week for ... by the U.S. Environmental Protection Agency (EPA) to dredge ... Passaic River. , The EPA has called the plan, ... sediments and capping sections of the riverbed, one of ... material would be dredged and disposed off-site. , "We ...
Breaking Biology News(10 mins):Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4New imaging agent provides better picture of the gut 2Experts Weigh the Pros and Cons of a $1.7 Billion EPA Cleanup Plan for the Passaic River at an NJIT 2
... waves, heavy rains and droughts that climate change will bring, ... Wednesday at a contentious U.S. Senate hearing on climate change, ... stark yet hopeful analogy. Just as speeding increases the ... risk of heat waves, droughts and heavy precipitation, said Field, ...
... been identified for the first time in wild marine fish ... University, UK, and the Australian Institute of Marine Science published ... reveals the incidence of melanoma in the coral trout, a ... the world,s largest hole in the ozone layer., This is ...
... earth, an influential community of microbes mingles with plant ... scientists have now catalogued and compared the hundreds of ... the model plant Arabidopsis under various conditions. ... plants interact with a microbial community that can influence ...
Cached Biology News:Stanford expert brings climate change science to heated Capitol Hill 2Skin cancer identified for the first time in wild fish populations 2Roots and microbes: Bringing a complex underground ecology into the lab 2Roots and microbes: Bringing a complex underground ecology into the lab 3Roots and microbes: Bringing a complex underground ecology into the lab 4Roots and microbes: Bringing a complex underground ecology into the lab 5
(Date:7/25/2014)... from the University of Leicester has furthered our ... potential to create new materials using nanosized ,building ... in the prestigious academic journal Physical Review ... examine in rich detail the structure and internal ... acetylene molecule and a single helium atom. , ...
(Date:7/25/2014)... Livermore, California (PRWEB) July 25, 2014 ... been named to Thomson Reuters list of " The ... Pitz are part of the 3,000 researchers who were ... years to recognize those who published the highest-impact work ... numerous research papers on combustion modeling . , ...
(Date:7/24/2014)... 24, 2014 -- Keryx Biopharmaceuticals, Inc. (Nasdaq:KERX) (the "Company") ... active control Phase 3 study of Zerenex (ferric citrate), ... the treatment of hyperphosphatemia in patients with end-stage renal ... and iRon delivery with FErric CiTrate in EsrD) was ... American Society of Nephrology ( JASN ). ...
(Date:7/24/2014)... -- ECC West Africa, LLC (ECC) signed a contract in ... Hospital (UCH) Ibadan Board of Management for the first ... and operate and maintain a new, state-of-the-art Cancer Institute ... first of the 4-phase project, ECC will conduct feasibility ... Ibadan intends to finance and develop the Cancer Institute ...
Breaking Biology Technology:Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2
... Secretary to visit independent Ukraine also visits ... MaxWell,s newly-built Boryspil facility -, ... Commerce,Secretary Carlos Gutierrez became the first U.S. cabinet official ... (Logo: http://www.newscom.com/cgi-bin/prnh/20080624/NETU078LOGO ), Gutierrez joined ...
... for Inflammation and Pain, TAMPA, Fla., June ... biopharmaceutical company, announced,today that the U.S. Food and ... for Durezol(TM) (difluprednate ophthalmic emulsion) 0.05%,a topical steroid ... The approval came after a six month priority ...
... France, June 24 Today, Stallergenes,has been granted ... Oralair(R) Grasses in adults, by PEI (Paul Ehrlich,Institute), ... Based on the positive results of the ... a paediatric extension of the,product,s indications., Stallergenes ...
Cached Biology Technology:U.S. Commerce Secretary Gutierrez Cuts Ribbon on MaxWell Biocorporation's New Pharmaceutical Development Center and Quality Control Laboratory in Ukraine 2Sirion Therapeutics Announces FDA Approval of Durezol(TM) for Treatment of Postoperative Ocular Inflammation and Pain 2Sirion Therapeutics Announces FDA Approval of Durezol(TM) for Treatment of Postoperative Ocular Inflammation and Pain 3Stallergenes : Sublingual Desensitisation Tablets Oralair Grasses Approved in Germany 2Stallergenes : Sublingual Desensitisation Tablets Oralair Grasses Approved in Germany 3
... Single Cell Whole Genome Amplification Kit ... random fragmentation of genomic DNA and ... to PCR-amplifiable library molecules flanked by ... by PCR amplification of the library ...
Rabbit Anti-Mouse Ym1 Polyclonal Antibody,...
ABgene® supplies a 94kDa ultra-pure recombinant thermostable DNA polymerase obtained by high level expression of the Taq DNA polymerase gene in E. coli....
Heavy-duty rim. Especially recommended as a titration flask. Corning5100. capacity 250 mL Special grade: student grade...
Biology Products: