Navigation Links
Structure of 450 million year old protein reveals evolution's steps
Date:8/16/2007

A detailed map that pinpoints the location of every atom in a 450-million-yeard-old resurrected protein reveals the precise evolutionary steps needed to create the molecules modern version, according to researchers from the University of North Carolina at Chapel Hill and the University of Oregon.

Until now, scientists trying to unravel the evolution of the proteins and other molecules necessary for life have worked backwards, making educated guesses based on modern human body chemistry. By moving forward from an ancient protein, the team laid out the step-by-step progression required to reach its current form and function.

The study appears in the Aug. 17, 2007, issue of the journal Science.

We were able to see exactly how mutations in the ancient structure led to the modern receptor, said lead author Eric Ortlund, who carried out the research as a UNC-Chapel Hill postdoctoral fellow. Ortlund is now an assistant professor of biochemistry in the Emory University School of Medicine.

In the current study, Ortlund and Matt Redinbo, a professor of chemistry, biochemistry and biophysics at UNC-Chapel Hill, generated a three-dimensional picture of the ancient receptor with an imaging technique called X-ray crystallography. The nanoscale image revealed the receptors structure, down to the placement of every atom. With the structure in place, Ortlund and his colleagues retraced evolutions path.

The researchers examined the precursor to a modern protein known as a glucocorticoid receptor. In humans, the receptor plays a crucial role, responding to the hormone cortisol and regulating the bodys stress response. The two receptor and hormone fit together as precisely as a lock and key. The precursor preferred a different hormone, so several mutations were necessary before the lock could fit the cortisol key.

The University of Oregon team, which included postdoctoral scientist Jamie Bridgham, resurrected the ancient pr
'/>"/>

Contact: Becky Oskin
becky_oskin@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Man and mouse share genome structures
2. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
3. Scientists solve structure of key protein in innate immune response
4. Vascular structure and function improve with diet and exercise
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. SuperLigands - a database of ligand structures derived from the Protein Data Bank
7. Structure-building cell signals also may influence learning and memory
8. PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information
9. DNA constraints control structure of attached macromolecules
10. Scripps research scientists solve structure of a critical innate immune system protein
11. Major advance made on DNA structure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... , June 23, 2015   Valencell, ... announced the results of a recent study that ... on the wrist during activity. In a study ... was compared along with the Apple Watch against ... measuring heart rate during activity. The study demonstrated ...
(Date:6/17/2015)... and HILDEN, Germany , June 17, 2015 ... Frankfurt Prime Standard: QIA) today launched new Investigator ® ... laboratories in the United States . The ... analyze multiple key genomic markers (short tandem repeats or STRs) ... Sensor to evaluate the quality of DNA in each sample, ...
(Date:6/16/2015)... , June 16, 2015 Fingerprint Cards ... fingerprint sensors in the company,s portfolio from one of its ... planned to mainly take place during the third quarter 2015. ... Asia . Jörgen Lantto, CEO of ...   the   growing interest from smartphone OEMs in integrating ...
Breaking Biology News(10 mins):Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2
... doses of an experimental H5N1 avian influenza vaccine can ... half of those volunteers who received an initial and ... vaccine tested in the trial developed levels of infection-fighting ... The National Institute of Allergy and Infectious Diseases (NIAID), ...
... a benign lifestyle in the soil to that of a ... Inhaled into the lungs of a mammal, spores from a ... encounter a new, warmer environment. And as soon as they ... pathogenic yeast, causing such serious and sometimes deadly afflictions as ...
... study from the forthcoming issue of The American Naturalist ... of females in many diving beetle populations. Their findings ... arises when the costs and benefits of multiple matings ... male versus female arms race (involving physical structures, behaviors, ...
Cached Biology News:H5N1 avian flu virus vaccine induces immune responses in healthy adults 2H5N1 avian flu virus vaccine induces immune responses in healthy adults 3Wisconsin scientists discover a master key to microbes' pathogenic lifestyles 2Wisconsin scientists discover a master key to microbes' pathogenic lifestyles 3
(Date:7/3/2015)... , July 3, 2015  Pomerantz LLP announces ... Puma Biotechnology, Inc. ("Puma" or the "Company")(NYSE: PBYI ... filed in United States District Court, Central District of ... is on behalf of a class consisting of all ... 23, 2014 and May 13, 2015 inclusive (the "Class ...
(Date:7/2/2015)...  Spherix Incorporated (Nasdaq: SPEX ) -- an intellectual property ... intellectual property, today announced a litigation update. ... Services Corp. et al. , Case No. 1:14-cv-00721-GBL-TCB, in ... of Virginia , the Court issued ... key claims in favor of the Defendants on the ...
(Date:7/1/2015)... ... July 01, 2015 , ... It is now possible to separate two ... photon emission computed tomography (SPECT) according to researchers from Amen Clinics, UCLA, Thomas ... brain scans and is believed to be the largest brain imaging study ever, will ...
(Date:7/1/2015)... Colo. and BANGALORE, India ... global genomic profiling company that uses next generation sequencing ... of Scott A. Storrer as chief executive ... CEO, he will be responsible for all strategy, business ... Chandru , who has served as Strand,s chairman and ...
Breaking Biology Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 2SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 3SHAREHOLDER ALERT: Pomerantz Law Firm Reminds Shareholders with Losses on their Investment in Puma Biotechnology, Inc. of Class Action Lawsuit and Upcoming Deadline - PBYI 4Spherix Issues A Litigation Update 2Spherix Issues A Litigation Update 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 2Strand Life Sciences Names Scott A. Storrer CEO as Company Continues Global Expansion with Focus on Precision Medicine Product 3
... 2009 Waukesha Electric Systems, SuperPower, University of Houston, Oak ... in a $10.7 million smart grid demonstration project award ... on November 24. The funds will be used to ... the reliability of the nation,s power grid. , ...
... 22 /PRNewswire/ - Viron Therapeutics Inc., a biotechnology company ... that it has been granted U.S. patents related to ... These patents join a portfolio of more than 80 ... drug discovery platform identifies proteins expressed by non-human viruses ...
... , , , , SEATTLE, Dec. 22 ... announced today its support of the Pharmaceutical Research Manufacturers ... revised July 2008" (PhRMA Code). Adherence to the ... , "As CTI prepares for the potential launch ...
Cached Biology Technology:Waukesha Electric partners with SuperPower and UH to build fault current limiting superconducting transformer for Dept. of Energy 2Waukesha Electric partners with SuperPower and UH to build fault current limiting superconducting transformer for Dept. of Energy 3Viron granted U.S. Patents for Organ Transplant and Arthritis Drug Candidates 2Viron granted U.S. Patents for Organ Transplant and Arthritis Drug Candidates 3Cell Therapeutics Commits to PhRMA's Code on Interactions With Healthcare Professionals 2Cell Therapeutics Commits to PhRMA's Code on Interactions With Healthcare Professionals 3Cell Therapeutics Commits to PhRMA's Code on Interactions With Healthcare Professionals 4
Mouse monoclonal [SPM302] to BCAR1, prediluted ( Abpromise for all tested applications). entrezGeneID: 9564 SwissProtID: P56945...
Phosphotyrosine IgG mouse monoclonal antibody: Alkaline Phosphatase conjugate...
Rabbit polyclonal to Myosin VIIa (rating: *****) ( Abpromise for all tested applications). entrezGeneID: 4647 SwissProtID: Q13402...
Mouse monoclonal [6E10] to LAP2 ( Abpromise for all tested applications). entrezGeneID: 7112 SwissProtID: P42166...
Biology Products: