Navigation Links
Structure of 450 million year old protein reveals evolution's steps
Date:8/16/2007

A detailed map that pinpoints the location of every atom in a 450-million-yeard-old resurrected protein reveals the precise evolutionary steps needed to create the molecules modern version, according to researchers from the University of North Carolina at Chapel Hill and the University of Oregon.

Until now, scientists trying to unravel the evolution of the proteins and other molecules necessary for life have worked backwards, making educated guesses based on modern human body chemistry. By moving forward from an ancient protein, the team laid out the step-by-step progression required to reach its current form and function.

The study appears in the Aug. 17, 2007, issue of the journal Science.

We were able to see exactly how mutations in the ancient structure led to the modern receptor, said lead author Eric Ortlund, who carried out the research as a UNC-Chapel Hill postdoctoral fellow. Ortlund is now an assistant professor of biochemistry in the Emory University School of Medicine.

In the current study, Ortlund and Matt Redinbo, a professor of chemistry, biochemistry and biophysics at UNC-Chapel Hill, generated a three-dimensional picture of the ancient receptor with an imaging technique called X-ray crystallography. The nanoscale image revealed the receptors structure, down to the placement of every atom. With the structure in place, Ortlund and his colleagues retraced evolutions path.

The researchers examined the precursor to a modern protein known as a glucocorticoid receptor. In humans, the receptor plays a crucial role, responding to the hormone cortisol and regulating the bodys stress response. The two receptor and hormone fit together as precisely as a lock and key. The precursor preferred a different hormone, so several mutations were necessary before the lock could fit the cortisol key.

The University of Oregon team, which included postdoctoral scientist Jamie Bridgham, resurrected the ancient pr
'/>"/>

Contact: Becky Oskin
becky_oskin@unc.edu
919-962-8596
University of North Carolina at Chapel Hill
Source:Eurekalert

Page: 1 2

Related biology news :

1. Man and mouse share genome structures
2. The Shapes Of Life: NIGMS Project Yields More Than 1,000 Protein Structures
3. Scientists solve structure of key protein in innate immune response
4. Vascular structure and function improve with diet and exercise
5. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
6. SuperLigands - a database of ligand structures derived from the Protein Data Bank
7. Structure-building cell signals also may influence learning and memory
8. PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information
9. DNA constraints control structure of attached macromolecules
10. Scripps research scientists solve structure of a critical innate immune system protein
11. Major advance made on DNA structure
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2015)... Conn. , Aug. 17, 2015  NXT-ID, Inc. ... biometric authentication company focused on the growing mobile commerce ... its new sales campaign for Q4 2015. The new ... marketing team consisting of Amplitude Marketing Group ( http://amplitudemarketing.com/ ... Marketing Group is a leader in retail driven marketing ...
(Date:8/12/2015)... Florida , August 12, 2015 ... pace of mobile payment innovation and advanced biometrics technology ... replace the way consumers rely on using their credit ... with reinventing the future for payment services led by ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ...
(Date:8/12/2015)... Calif. , Aug. 12, 2015  Synaptics ... of human interface solutions, today announced that four ... announced Match-in-Sensor solution, have officially been named FIDO ... As part of the certification, Synaptics, Natural ID™ ... 1.0 Universal Authentication Framework (UAF) standard and are ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3
... German . The images ... many: in the autumn of 2004, former President of the Ukraine, Viktor ... the attack, the chloracne caused by the poisoning, officially known as MADISH, ... left deep scars. Now a team of researchers headed by ETH-Zurich ...
... 6, 2014Today The Sackler Institute for Nutrition Science at ... a launch event for Every Child,s Potential: Integrating Early ... Annals of the New York Academy of Sciences . ... two highly complementary fields: nutrition and child development. , ...
... Calif.) Carbon dioxide emissions from transportation, energy generation ... change, but they may not be the biggest ones. ... A. Cleveland, that dubious distinction could go to the ... a Planet: The Future of Food and Agriculture," Cleveland ...
Cached Biology News:Two sides of a safety switch 2Two sides of a safety switch 3'Meeting Post-MDG Challenges: Integrating Nutrition and Child Development Interventions' 2'Meeting Post-MDG Challenges: Integrating Nutrition and Child Development Interventions' 3Book empowers readers to help solve the food crisis 2Book empowers readers to help solve the food crisis 3
(Date:9/3/2015)... MA (PRWEB) , ... September 03, 2015 , ... If ... conference in Boston this October, you will also want to sign up for ... Sunday, October 18th. The tour includes a walk through of the (8) chemistry ...
(Date:9/2/2015)... and LIBERTYVILLE, Ill. (PRWEB) , ... ... ... International, a leading provider of regulatory compliance, quality systems, analytical testing, education ... a consulting firm with expertise in medical device products/processes development, design control, ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... with the use of special anti-vascular endothelial growth factor agents given by injection ... currently does not have a scientific protocol for the many millions diagnosed with ...
(Date:9/2/2015)... Research and ... addition of Jain PharmaBiotech,s new report ... to their offering. The scope ... in situ hybridization (FISH), comparative genomic hybridization ... application of nanobiotechnology, microarrays, real-time polymerase chain ...
Breaking Biology Technology:Erlab Invites You to Tour the Largest Installation of Filtered Fume Hoods in the World 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7StemCell GeneticMed Announces That It Has Started Stem Cell Treatments for Age Related Dry Macular Degeneration (AMG) 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 2Global Cytogenetics Technologies Study 2015-2025 - Latest Markets and Companies Analysis 3
... RIVER, N.Y., June 20, 2011 ... provider of software and services for health and ... 4.2 electronic health record (EHR) software for behavioral ... ARRA Ambulatory Certification. (Logo: http://photos.prnewswire.com/prnh/20110620/NY22778LOGO) ...
... VICTORIA, Australia, June 20, 2011 Genetic Technologies Limited ... North American division, Phenogen Sciences Inc., has launched the ... risk.   Phenogen Sciences will target its ... US metro-markets.  The company has deployed its sales force ...
... ,Graphene, a one-atom-thick layer of graphitic carbon, has the ... But its unique properties, and the shrinking scale of ... produce on a large scale. In ... had overcome some of these difficulties and were able ...
Cached Biology Technology:CMHC/MIS Electronic Health Record Solution from Netsmart Technologies Attains Complete ARRA Certification 2CMHC/MIS Electronic Health Record Solution from Netsmart Technologies Attains Complete ARRA Certification 3CMHC/MIS Electronic Health Record Solution from Netsmart Technologies Attains Complete ARRA Certification 4Genetic Technologies Launches BREVAGen™ Breast Cancer Risk Test in US 2Genetic Technologies Launches BREVAGen™ Breast Cancer Risk Test in US 3Genetic Technologies Launches BREVAGen™ Breast Cancer Risk Test in US 4UCLA team reports scalable fabrication of self-aligned graphene transistors, circuits 2
... FLAG Immunoprecipitation kit allows a rapid ... an active FLAG-tagged protein. The immunoprecipitation ... which is a highly specific monoclonal ... The use of affinity resin allows ...
... CromoCenSC is a chromogenic medium ... count of Salmonella (except S. thyphi) ... bacteria. ,The detection takes a maximum ... biochemical tests, no sterilization during preparation ...
...
...
Biology Products: