Navigation Links
Structural Genomics Consortium releases 1,000th protein structure
Date:9/28/2010

The Structural Genomics Consortium (SGC), an international public-private partnership that aims to determine three dimensional structures of medically important proteins, announced today the release into the public domain of its 1000th high resolution protein structure.

The 1000th structure known as JmjD2C belongs to a class of proteins involved in epigenetic signalling, a key research area for the SGC. Epigenetics is the study of inherited changes in gene expression caused by proteins such as JmjD2C which 'switch' genes on or off. It is believed that a better understanding of epigenetics could lead to new treatments for a wide variety of diseases including cancer, diabetes, obesity and many psychiatric diseases.

"JmjD2C is already known to play a key a role in the maintenance of self renewal in stem cells as well as roles in cancer," says Professor Udo Oppermann of SGC Oxford, who led the team solving the 1000th structure. "Now that its 3D structure is in the public domain, we hope that this will spur other scientists to investigate its functions more deeply and understand more clearly its role in epigenetics."

"This milestone reinforces the advantages of open-innovation partnerships between the public and private sectors," says Dr Aled Edwards the SGC Chief Executive. "We're extremely proud of this achievement and the efforts of our co-workers and their collaborators around the world."

Formed in 2004, the SGC comprises 180 scientists at labs at the Universities of Oxford and Toronto, and the Karolinska Institutet in Stockholm. The international collaboration is supported by public and private sector funding. All research output is made available to the research community free from restriction on use and protein structures are deposited in the Protein Data Bank (PDB). In 2009, the SGC contributed nearly a third of all new human proteins structures deposited in the PDB, and a similar fraction of protein structures from pathogenic protozoa.

The vast amount of structural information generated by the SGC provides insights into molecular function and is expected to have a great impact on human health by providing a structural framework for the rational chemical design of new or improved drugs that can inhibit or enhance protein function.

"The SGC is providing an incredibly valuable resource to the entire biomedical research community," says Professor Ray Stevens, Department of Molecular Biology and Chemistry at The Scripps Research Institute in La Jolla, USA. "Its systematic approach targeting entire protein families, such as protein kinases and other important as well as potential drug target classes, has yielded data that will be very helpful for investigators working to understand further the roles these proteins play in key biological functions. I applaud them for their efforts and accomplishments."

Since its launch, the SGC has identified and deposited in the PDB key protein structures involved in all aspects of cellular function and linked to diseases such as cancer, inflammation, diabetes, neurological disorders and infection. Many of the structures have also been published in scientific articles. Most publications, totalling over 250, are the result of collaborative projects with other scientists utilizing the structural information; the SGC is involved in more than 200 active collaborations with academics around the world.

Dr Alan Schafer, Director of Science Funding at the Wellcome Trust, comments: "The SGC has achieved a remarkable milestone in depositing its thousandth structure in the public domain. This success demonstrates the value of the public-private partnership model avoiding duplication of effort and allowing maximum benefit to the whole research community."


'/>"/>

Contact: Craig Brierley
c.brierley@wellcome.ac.uk
44-207-611-7329
Wellcome Trust
Source:Eurekalert  

Related biology news :

1. Pitt/Iowa team finds cellular structural molecule can be toxic: Makes pneumonia worse
2. Structural defects precede functional decline in heart muscle
3. University of Nevada professor studies structural basis for autism disorders
4. National Science Foundation awards grant to Oklahoma structural biology group
5. National Science Foundations awards grant to Oklahoma structural biology group
6. Structural biology scores with protein snapshot
7. NIH expands key pharmacogenomics resource
8. Paper offers new insights into the genomics of speciation
9. Symposium spotlights new paradigms in genomics, celebrates AIDS-fighting drug at 25 years
10. MIT student inventor honored for transformative work in genomics and linguistics
11. The impact of genomics
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Structural Genomics Consortium releases 1,000th protein structure
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
Breaking Biology News(10 mins):
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS ... announced the launch of its new line of Rocking and Waving Shakers today. ... shaker models (both analog and digital) for laboratory applications in a variety of ...
(Date:7/15/2017)... Staten Island, NY (PRWEB) , ... July 15, 2017 , ... ... field for over 5 years. During this time, the people at FFS have ... learning from their customers, engineers at FFS are able to launch new products to ...
(Date:7/14/2017)... AZ (PRWEB) , ... July 13, 2017 , ... Dr. ... for ailing dental implants into his practice, Mondlick Perio, in the Phoenix area. ... with the world's first and only FDA cleared laser treatment to re-grow bone and ...
(Date:7/14/2017)... Germany (PRWEB) , ... July 14, 2017 , ... ... standardized solution for sample preparation of proteins to clean peptides for mass spectrometry ... sonication system. , The PreOmics iST Kit is based on proprietary technology ...
Breaking Biology Technology: