Navigation Links
Structural Genomics Consortium releases 1,000th protein structure

The Structural Genomics Consortium (SGC), an international public-private partnership that aims to determine three dimensional structures of medically important proteins, announced today the release into the public domain of its 1000th high resolution protein structure.

The 1000th structure known as JmjD2C belongs to a class of proteins involved in epigenetic signalling, a key research area for the SGC. Epigenetics is the study of inherited changes in gene expression caused by proteins such as JmjD2C which 'switch' genes on or off. It is believed that a better understanding of epigenetics could lead to new treatments for a wide variety of diseases including cancer, diabetes, obesity and many psychiatric diseases.

"JmjD2C is already known to play a key a role in the maintenance of self renewal in stem cells as well as roles in cancer," says Professor Udo Oppermann of SGC Oxford, who led the team solving the 1000th structure. "Now that its 3D structure is in the public domain, we hope that this will spur other scientists to investigate its functions more deeply and understand more clearly its role in epigenetics."

"This milestone reinforces the advantages of open-innovation partnerships between the public and private sectors," says Dr Aled Edwards the SGC Chief Executive. "We're extremely proud of this achievement and the efforts of our co-workers and their collaborators around the world."

Formed in 2004, the SGC comprises 180 scientists at labs at the Universities of Oxford and Toronto, and the Karolinska Institutet in Stockholm. The international collaboration is supported by public and private sector funding. All research output is made available to the research community free from restriction on use and protein structures are deposited in the Protein Data Bank (PDB). In 2009, the SGC contributed nearly a third of all new human proteins structures deposited in the PDB, and a similar fraction of protein structures from pathogenic protozoa.

The vast amount of structural information generated by the SGC provides insights into molecular function and is expected to have a great impact on human health by providing a structural framework for the rational chemical design of new or improved drugs that can inhibit or enhance protein function.

"The SGC is providing an incredibly valuable resource to the entire biomedical research community," says Professor Ray Stevens, Department of Molecular Biology and Chemistry at The Scripps Research Institute in La Jolla, USA. "Its systematic approach targeting entire protein families, such as protein kinases and other important as well as potential drug target classes, has yielded data that will be very helpful for investigators working to understand further the roles these proteins play in key biological functions. I applaud them for their efforts and accomplishments."

Since its launch, the SGC has identified and deposited in the PDB key protein structures involved in all aspects of cellular function and linked to diseases such as cancer, inflammation, diabetes, neurological disorders and infection. Many of the structures have also been published in scientific articles. Most publications, totalling over 250, are the result of collaborative projects with other scientists utilizing the structural information; the SGC is involved in more than 200 active collaborations with academics around the world.

Dr Alan Schafer, Director of Science Funding at the Wellcome Trust, comments: "The SGC has achieved a remarkable milestone in depositing its thousandth structure in the public domain. This success demonstrates the value of the public-private partnership model avoiding duplication of effort and allowing maximum benefit to the whole research community."


Contact: Craig Brierley
Wellcome Trust

Related biology news :

1. Pitt/Iowa team finds cellular structural molecule can be toxic: Makes pneumonia worse
2. Structural defects precede functional decline in heart muscle
3. University of Nevada professor studies structural basis for autism disorders
4. National Science Foundation awards grant to Oklahoma structural biology group
5. National Science Foundations awards grant to Oklahoma structural biology group
6. Structural biology scores with protein snapshot
7. NIH expands key pharmacogenomics resource
8. Paper offers new insights into the genomics of speciation
9. Symposium spotlights new paradigms in genomics, celebrates AIDS-fighting drug at 25 years
10. MIT student inventor honored for transformative work in genomics and linguistics
11. The impact of genomics
Post Your Comments:
Related Image:
Structural Genomics Consortium releases 1,000th protein structure
(Date:11/20/2015)... November 20, 2015 NXTD ) ... on the growing mobile commerce market and creator of ... Pereira , was recently interviewed on The RedChip ... on this weekend on Bloomberg Europe , Bloomberg ... --> NXTD ) ("NXT-ID" or the "Company"), ...
(Date:11/19/2015)...  Although some 350 companies are actively involved in ... companies, according to Kalorama Information. These include Roche Diagnostics, Hologic, ... share of the 6.1 billion-dollar molecular testing market, according ... Molecular Diagnostic s .    ... by one company and only a handful of companies ...
(Date:11/18/2015)... November 18, 2015 --> ... a new market report titled  Gesture Recognition Market - ... 2015 - 2021. According to the report, the global gesture recognition ... anticipated to reach US$29.1 bn by 2021, at a ... North America dominated the global gesture ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... LUMPUR, Malaysia , Nov. 24, 2015 /PRNewswire/ ... global contract research organisation (CRO) market. The trend ... result in lower margins but higher volume share ... increased capacity and scale, however, margins in the ... Research Organisation (CRO) Market ( ), ...
(Date:11/24/2015)... ... November 24, 2015 , ... Copper is an essential ... bound to proteins, copper is also toxic to cells. With a $1.3 million ... (WPI) will conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa ...
(Date:11/24/2015)... ... November 24, 2015 , ... This fall, global software ... events in five states to develop and pitch their BIG ideas to improve health ... state are competing for votes to win the title of SAP's Teen Innovator, an ...
(Date:11/24/2015)... /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: ... 11,000 post-share consolidation (or 1,100,000 pre-share consolidation) Series ... Warrants") subject to the previously disclosed November 1, ... which will result in the issuance of 365,518 ... issuance of such shares, there will be approximately ...
Breaking Biology Technology: