Navigation Links
Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer
Date:2/3/2009

d sent to Professor Richard Iggo's laboratory which was at the Swiss Institute for Experimental Cancer Research (ISREC) in Lausanne at the time of the study, which was to a large part sponsored by the National Center of Competence in Research (NCCR) in Molecular Oncology. In Lausanne, the genomic material (mRNA) of tumor samples were extracted and profiled on microarrays in order to measure the expression activity pattern of thousands of individual genes.

Meanwhile, all patients included in the said study had a tumor biopsy prior to receiving an anthracyclin-based chemotherapy followed by surgical excision of the tumour a protocol that clinicians call neo-adjuvant chemotherapy. After the surgical intervention, pathologists analysed the surgical specimen and determined if tumor cells were still present. This is a way to measure the efficacy of the chemotherapy.

If no tumor cells were found, the patient was considered to be fully responsive to the treatment (defined as "complete pathological response"). The aim of the study was to test if genomic analysis of the tumor taken before chemotherapy treatment could allow the identification a signature which permits the prediction of the patients who would respond to the chemotherapy.

To achieve this task, Drs Farmer, Mauro Delorenzi, and Pratyaksha Wirapati from the Swiss Institute of Bioinformatics developed new computational methods to extract relevant gene patterns from the vast quantity of data generated by the microarray experiment. "In this study, we have mined the gene expression data in order to find a particular gene activity pattern, or gene signature, that would be associated with how patients respond to chemotherapy," Dr Farmer said.

Results showed that a signature measuring the biological activity of tumor's microenvironment, also known as reactive stroma, predicted how patients would respond to the treatment.

Researchers found that it is precisely the magni
'/>"/>

Contact: Janice Blondeau
janice.blondeau@isb-sib.ch
41-216-924-054
Swiss Institute of Bioinoformatics
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. DNA replication behavior in complex organisms may foreshadow leaps in genomic discoveries
2. UCI and CODA Genomics collaborate to re-engineer yeast for biofuel production
3. Metagenomics of the deep Mediterranean
4. Metagenomics of the deep Mediterranean
5. Inconsistencies with Neanderthal genomic DNA sequences
6. Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
7. NYUs Center for Genomics & Systems Biology receives $4.4 million NSF grant
8. Human RecQ helicases, homologous recombination and genomic instability
9. Virginia Tech plant scientist leads study on genomics of parasitic plants
10. Study finds health professionals, public unprepared for genomic medicine
11. At home genomic tests for disease risk premature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 Research and Markets ( ... "Global Wearable Technologies Market and Applications, Opportunities, ... and Forecast 2014-2020" report to their offering. ... devices that can be worn on the user,s ...
(Date:12/24/2014)... , Dec. 23, 2014  Since its launch in December 2014, ... to eliminate the pain of trying to remember their usernames ... biometrics fused to their smartphones. To assist people who have ... the company that created 1U and focuses on redefining identity, ...
(Date:12/22/2014)... , Dec. 22, 2014  The 2014 Holiday Season ... as Acuity Market Intelligence reports that the long anticipated ... forecasts that intensifying demand for smart phones, tablets, and ... global market of 2.5 billion users with nearly 4.8 ...
Breaking Biology News(10 mins):Global Wearable Technologies Market and Applications, Opportunities, Industry Analysis, Segmentation, Size, Growth, Share, Overview, Trends and Forecast 2014-2020 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 2
... as well known for keeping us healthy as it is ... a new research report appearing in the March 2010 print ... scientists explain how they developed a genetically modified strain of ... scum, scientifically known as microcystin-LR (MC-LR), which makes water unsafe ...
... silkworm moths, butterflies and spiders, caddisfly larvae spin silk, but ... of Utah researchers have discovered why the fly,s silk is ... as an adhesive tape during surgery. "Silk from caddisfly ... may be useful some day as a medical bioadhesive ...
... of business for any fledgling plant embryo is to determine which ... researchers at the Salk Institute expose the turf wars between two ... polar axis with a root on one end and a shoot ... important decision for a plant, setting up the root/shoot axis, occurs ...
Cached Biology News:Glue, fly, glue 2Glue, fly, glue 3Glue, fly, glue 4Glue, fly, glue 5Root or shoot 2Root or shoot 3
(Date:1/22/2015)... , Jan. 22, 2015   GenoSpace , a precision medicine ... to enable the broad use of genomic, imaging and other ... appointment of Michelle Munson , CEO of Aspera, an ... Logo - http://photos.prnewswire.com/prnh/20150122/170713 "We ...
(Date:12/24/2014)... YORK , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, Inc. ... critical areas, announced the closing of an underwritten public offering ... up to an aggregate 3,500,000 shares of common stock, at ... warrant.  The warrants have a per share exercise price of ...
(Date:12/24/2014)... 2014 GMO corn cases filed across the ... the process of being consolidated in a Kansas federal court ... AG MIR 162 Corn Litigation, MDL No. 2591 in the ... of the Syngenta GMO corn multidistrict litigation (MDL) has been ...
(Date:12/24/2014)... Island, New York (PRWEB) December 23, 2014 ... and the Long Island Affiliate of ITRA Global, the national ... slow but steady recovery. This is evidenced by the ... the strong stock market. Low energy costs have held ...
Breaking Biology Technology:GenoSpace Expands Board with Appointment of Michelle Munson 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3
... -- I continue to be encouraged by the numerous ... Midwest. Here are just a few: , ,& bull; The ... 2006. , ,& bull; The continued acquisition of Midwest ... recognize the value of Midwest products and technology, the flip ...
... in Memphis, Tenn., will install a wireless distribution ... organization's corporate office under a $6 million agreement with ... distribution system will provide wireless coverage throughout Baptist's six ... system, which will be installed in the next 12 ...
... a biophysical chemist at the University of Wisconsin-Madison, has ... the Biophysical Society, a 7,000-member U.S. organization that represents ... and biochemistry, Record hopes that the new honor will ... funding for his research. , ,A UW-Madison faculty member ...
Cached Biology Technology:Midwest biotech on a roll 2Midwest biotech on a roll 3Midwest biotech on a roll 4
... Engine Dyad instrument is the most advanced ... MJ's world-class thermal performance, the Dyad also ... well as point-and-click navigation via touch pad ... be easily and economically expanded to a ...
...
...
... instrument is the most advanced thermal cycler ... thermal performance, the Dyad also boasts graphical ... point-and-click navigation via touch pad or mouse. ... and economically expanded to a four-bay system ...
Biology Products: