Navigation Links
Stroma genomic signature predicts resistance to anthracyclin-based chemotherapy in breast cancer
Date:2/3/2009

Researchers at the Swiss Institute of Bioinformatics and the Swiss National Center of Competence in Research in Molecular Oncology in Lausanne have developed a new test to predict how breast cancer patients respond to chemotherapy, which could help change how treatment is delivered in the future. In an article, 'A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer' i, published in Nature Medicine, Dr Pierre Farmer and colleagues showed the potential of the reactive stroma to modulate tumor phenotype and the clinical response to treatment. This is a major step forward in the field as identifying factors that influence response to cancer chemotherapy is crucial for improving its efficacy.

The study first started when a team of clinicians, cancer biologists and computational biologists combined their effort to address a very puzzling question: Why breast tumors that have very similar conditions in terms of aggressiveness (grade), invasiveness (node status) and hormone dependency (ER status), respond differently to the same kind of chemotherapy treatment.

"Two breast cancer patients might respond very differently to the same type of chemotherapy although their respective tumors are very similar from a clinical point of view," said Dr Pierre Farmer. "The reasons for these different responses are unknown."

To help find an answer to this question, a collaborative study was set-up within the framework of a large randomized clinical trial that involved more than 40 different hospitals throughout Europe, including those in the UK, France, Belgium, Netherlands, Poland, Sweden and Switzerland. It was led by Professor Herv Bonnefoi of the European Organization for Research and Treatment of Cancer (EORTC) in collaboration with the Swedish Breast Cancer Group (SBCG), the Swiss Cancer Group (SAKK) and the Angloceltic group (ACOG).

In this trial, biopsies were taken from each patient an
'/>"/>

Contact: Janice Blondeau
janice.blondeau@isb-sib.ch
41-216-924-054
Swiss Institute of Bioinoformatics
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. DNA replication behavior in complex organisms may foreshadow leaps in genomic discoveries
2. UCI and CODA Genomics collaborate to re-engineer yeast for biofuel production
3. Metagenomics of the deep Mediterranean
4. Metagenomics of the deep Mediterranean
5. Inconsistencies with Neanderthal genomic DNA sequences
6. Microarray sequence capture speeds large-scale resequencing of targeted genomic regions
7. NYUs Center for Genomics & Systems Biology receives $4.4 million NSF grant
8. Human RecQ helicases, homologous recombination and genomic instability
9. Virginia Tech plant scientist leads study on genomics of parasitic plants
10. Study finds health professionals, public unprepared for genomic medicine
11. At home genomic tests for disease risk premature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 2015 La 10 th International Conference on ... BGI del 22 al 25 de octubre de 2015 en ... la conferencia celebra su décimo aniversario. Desde su inauguración en ... las reuniones anuales más influyentes del mundo en el campo ... entusiastas y mejores a nivel científico. ICG-10 ...
(Date:7/30/2015)... MOUNTAIN VIEW, Calif. , July 30, 2015 ... products and services for gene function analysis and ... CRISPR Guide RNA (sgRNA) Knockout Library targeting all ... to specifically and permanently "knock out" a gene,s ... library provides a high throughput screening tool so ...
(Date:7/23/2015)... , July 23, 2015 Research ... addition of the "Global Outlook of the ... offering. The global biometrics market ... public and commercial applications owing to the uptake ... witness a transformation that enhances the growth of ...
Breaking Biology News(10 mins):La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3
... The European eel is on the way to disappearing for ... scientific arguments for suspending all fishing. Despite this situation, Swedish ... management plan by the Swedish Institute for the Marine Environment ... the target that has been set for silver eels capable ...
... the German government to phase out nuclear power by 2022 ... than Germany or Japan, which is still coming to terms ... issue, published by the SETAC journal Environmental Toxicology and ... effects of radiation, using research from the Chernobyl disaster. ...
... a critical part of a human cell,s control system that is ... sensor known as the "gating ring" can open a channel that ... membrane similar to the way a subway turnstile allows people ... in the regulation of crucial bodily activities like blood pressure, insulin ...
Cached Biology News:Will the eel survive its management? 2UCLA scientists identify how major biological sensor in the body works 2UCLA scientists identify how major biological sensor in the body works 3
(Date:7/31/2015)... , ... July 31, 2015 , ... ... the detection and quantification of partially hydrolyzed gluten in foods, has been accepted ... adopted the method “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ...
(Date:7/30/2015)... , July 30, 2015   GenoSpace ... for the interpretation and analysis of genomic and ... Fischer has joined the company as Vice ... - http://photos.prnewswire.com/prnh/20150730/250931 "GenoSpace ... to integrate, interpret, analyze and explore complex sets ...
(Date:7/30/2015)... , July 30, 2015 ... by Product (Software, Molecular Modeling, PB/PK, PKPD, Trial Design, ... & Development, Preclinical, Clinical Trial), by End Users - ... Market is expected to reach USD 2,107.99 million by ... CAGR of 15.29%. Browse more than ...
(Date:7/30/2015)... , Inc. (NASDAQ: SNMX ), a leading company ... commercialize novel flavor ingredients for the food, beverage, and ... second quarter 2015. "Moving into the ... achieve our commercial and financial goals," stated John Poyhonen, ... our last quarterly earnings report, our two partners have ...
Breaking Biology Technology:RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 2SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 3SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 4SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 5SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 6SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 7SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 8SENOMYX ANNOUNCES SECOND QUARTER 2015 FINANCIAL RESULTS 9
... Aug. 5 Forensic Laboratories, a ... and alcohol abuse, has announced the expansion of its ... lab in the nation to develop an analytical test ... chemical produced by the body after alcohol exposure.  Forensic ...
... , PRINCETON, N.J. , Aug. 5 Signum Biosciences, ... CSO of Barrier Therapeutics, as Chief Executive Officer.  Dr. Shroot replaces Dr. ... Company as a member of the board. , ... " Braham Shroot brings to Signum ...
... KANSAS CITY, Kansas , Aug. 5 ... blood test that aids physicians in risk assessment and the ... a study that demonstrates the clinical validity of the test. The ... Cancer Diagnosis " is now available on line at Annals ...
Cached Biology Technology:Forensic Laboratories Develops First Oral Fluid Test for Ethyl Sulfate Detection 2Signum Biosciences Names Braham Shroot as Chief Executive Officer 2New Study Demonstrates Clinical Validity of EarlyCDT-Lung™ 2New Study Demonstrates Clinical Validity of EarlyCDT-Lung™ 3New Study Demonstrates Clinical Validity of EarlyCDT-Lung™ 4New Study Demonstrates Clinical Validity of EarlyCDT-Lung™ 5New Study Demonstrates Clinical Validity of EarlyCDT-Lung™ 6
... siSolutions siRNA Custom Synthesis ... effective duplex RNA to knockdown ... 21-mers (19 RNA base pairs ... recently-published 27-mers, or other lengths ...
Request Info...
...
Complete cell culture media with cytokines...
Biology Products: