Navigation Links
Stroke victims may benefit from stem cell transplants

Tampa, Fla. (Jan. 28, 2008) According to two studies published in the current issue of CELL TRANSPLANTATION (Vol.16 No.10), stroke victims may benefit from human mesenchymal stem cell (hMSC) or bone marrow stromal cell (BMSCs) transplantation. In both studies, the migration of chemically tagged transplanted stem cells were tracked to determine the degree to which the transplanted cells reached damaged areas of the brain and became therapeutically active.

Tracking transplanted hMSCs to infarcted areas

In a study carried out by Korean researchers, labeled hMSCs (early precursor cells to musculoskeletal, blood, vascular and urogenital systems) were transplanted into animal stroke models with cerebral artery occlusion and tracked by magnetic resonance imaging (MRI) at two days, one week, two weeks, six weeks and ten weeks after transplant.

Cells started showing indications of migration as early as one or two weeks following transplantation, said lead author Jihwan, Song, DPhil, of the Pochon CHA University College of Medicine. At 10 weeks, the majority of the cells were detected in the core of the infarcted area.

The study concluded that there is a strong tendency for transplanted hMSCs to migrate toward the infarcted area regardless of injection site but that the degree of migration was likely based on differences in each animals ischemic condition.

We speculate that the extensive migratory nature of stem cells and their utilization will provide an important tool for developing novel stroke therapies, said Song.

BMSCs migrate to damaged brain tissue, improve neural function

In a joint Canadian, Chinese study, BMSCs - connective tissue cells - were injected into animals 24 hours following middle cerebral artery occlusion. Using laser scanning confocal microscopy to track fluorescent signals and immuno markers attached to the cells, researchers found that within seven days of the injection the BMSCs had migrated through the region of the middle cerebral artery into the scar area and border zone of the ischemic region.

We evaluated vascular density in the ischemic region in all animals seven days after cell transplantation, said study lead author Ren-Ke Li, MD, PhD. The animals exhibited significant reductions in scar size and cell death and improvements in neurological function when compared to controls that received no BMSCs.

Researchers concluded that the intravenous delivery of bone marrow-derived cells may enhance tissue repair and, in turn, functional recovery after a stroke. While the potential mechanisms for this recovery are unclear, among the possibilities are that the brain microenvironment early on following a stroke may mimic brain development. Subsequent elevated levels of growth factors might enhance homing of BMSCs to the injured area and induce cell proliferation.

Our results support the potential therapeutic use of BMSCs after a stroke, concluded Li.

Editors comments:

Both studies lend important support to a growing body of laboratory evidence that bone marrow is a remarkable adult stem cell source for transplant therapy following stroke, says Cell Transplantation associate editor Cesar V. Borlongan, Ph.D. of the Medical College of Georgia. The non-invasive MRI visualization of pre-labeled BMSCs could become a routine clinical marker for transplanted cells as well as for safety and efficacy.


Contact: Jihwan Song
Cell Transplantation Center of Excellence for Aging and Brain Repair

Related biology news :

1. Blood pressure drug telmisartan shows powerful activity against stroke
2. Forests could benefit when fall color comes late
3. Biomass production -- careful planning can bring many benefits
4. SAGEs American Journal of Lifestyle Medicine looks at the health benefit of oats
5. Surprise -- cholesterol may actually pose benefits, study shows
6. RAND paper finds diesel, hybrid vehicles can provide more societal benefits than gas-powered autos
7. New Actemra data shows significant benefit for patients suffering from rheumatoid arthritis
8. New data shows benefits of MitraClip for patients with mitral regurgitation
9. The benefits of 80 million years without sex
10. Tufts University biologists link Huntingtons disease to health benefits in young
11. Medical breakthrough for organ transplants and cardiovascular diseases by Flemish researchers
Post Your Comments:
(Date:11/11/2015)... 11, 2015   MedNet Solutions , an innovative SaaS-based ... research, is pleased to announce that it will be a ... event, to be held November 17-19 in ... live demonstrations of iMedNet , MedNet,s easy-to-use, ... iMedNet has been able to deliver time and cost ...
(Date:11/9/2015)... Nov. 9, 2015  Synaptics Inc. (NASDAQ: SYNA ... announced broader entry into the automotive market with a ... the pace of consumer electronics human interface innovation. Synaptics, ... ideal for the automotive industry and will be implemented ... Europe , Japan , ...
(Date:10/29/2015)... 29, 2015  The J. Craig Venter Institute (JCVI) ... Synthesis and Biosecurity: Lessons Learned and Options for the ... and Human Services guidance for synthetic biology providers has ... --> --> Synthetic biology ... potential to pose unique biosecurity threats. It now is ...
Breaking Biology News(10 mins):
(Date:11/25/2015)... 26, 2015 --> ... 2016 - 2020 report analyzes that automating biobanking ... quality in long-term samples, minimizing manual errors, improving ... minimizes manual errors such as mislabeling or inaccurate ... it plays a vital role in blood fractionation, ...
(Date:11/25/2015)... , Nov. 25, 2015  Neurocrine Biosciences, Inc. ... Gorman , President and CEO of Neurocrine Biosciences, will ... Conference in New York . ... visit the website approximately 5 minutes prior to the ... replay of the presentation will be available on the ...
(Date:11/25/2015)... ... November 25, 2015 , ... Jessica Richman and ... early in their initial angel funding process. Now, they are paying it forward ... make early stage investments in the microbiome space. In this, they join ...
(Date:11/24/2015)... /CNW/ - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ... the quarter ended September 30, 2015. Amounts, unless ... presented under International Financial Reporting Standards ("IFRS"). ... Andrew Rae , President & CEO of ... only value enriching for this clinical program, but ...
Breaking Biology Technology: