Navigation Links
Stress signals link pre-existing sickness with susceptibility to bacterial infection
Date:7/28/2009

Mitochondrial diseases disrupt the power generating machinery within cells and increase a person's susceptibility to bacterial infection, particularly in the lungs or respiratory tract. A new study published in Disease Models & Mechanisms (DMM), shows that infection with the pneumonia causing bacteria Legionella, is facilitated by an increased amount of a signaling protein that is associated with mitochondrial disease.

Patients with mitochondrial disease exhibit a wide range of symptoms including diabetes, blindness, deafness, stroke-like episodes, epilepsy, ataxia, muscle weakness and kidney disease. The metabolic abnormalities that cause these effects also induce a stress signal intended to help the body overcome its energy deficit. The stress-signal induces the production of more mitochondria, the energy generating 'powerplants' of the body, in the hopes that more mitochondria will result in a better power supply. Researchers now show that the stress-signal associated with mitochondrial disease facilitates the growth and reproduction of the lung-infecting bacteria, Legionella.

Cells with mitochondrial disease increase their production of a signaling protein called AMP-activated protein kinase (AMPK), to promote the generation of more energy producing mitochondria. Infectious bacteria, like Legionella, target the mitochondria and might use them to supplement their own needs and survival requirements. By manipulating AMPK levels, scientists were able to directly influence the ability of bacteria to replicate inside of the single-celled organism, Dictyostelium.

Striking similarities that exist between simple organisms like Dictyostelium and humans allow scientists to use them to understand human disease. Dictyostelium is a free-living amoeba whose rapid movements make it useful to study motility and energy regulation, and in this case, the association between energy regulation and susceptibility to infection. Like humans, Dictyostelium can be infected by Legionella and quickly responds by producing a host of metabolism-associated proteins. Another similarity between humans and Dictyostelium is that both use AMPK as an internal sensor to coordinate energy synthesis with energy needs. However, unlike humans, researchers can infect Dictyostelium with germs like Legionella in a controlled environment and determine the influence of various parameters on the course of infection.


'/>"/>

Contact: Kristy Kain
kristy.kain@vanderbilt.edu
615-343-1298
The Company of Biologists
Source:Eurekalert

Related biology news :

1. Short stressful events may improve working memory
2. Stop and smell the flowers -- the scent really can soothe stress
3. Help for climate-stressed corals
4. Stress puts double whammy on reproductive system, fertility
5. Study finds link between individual stress and adolescent obesity
6. DNA repair mechanisms relocate in response to stress
7. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
8. New and unexpected mechanism identified how the brain responds to stress
9. Unexplained chest pain can be due to stress
10. Stress may hasten the growth of melanoma tumors
11. Stress disrupts human thinking, but the brain can bounce back
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... 2016  Perkotek an innovation leader in attendance control systems is proud to announce ... for employers to make sure the right employees are actually signing in, and to ... ... ... ...
(Date:6/2/2016)... NEW YORK , June 2, 2016   The ... (Weather), is announcing Watson Ads, an industry-first capability in which ... advertising, by being able to ask questions via voice or ... Marketers have long ... with the consumer, that can be personal, relevant and valuable; ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... 2016 , ... Cancer experts from Austria, Hungary, Switzerland, and ... new and helpful biomarker for malignant pleural mesothelioma. Surviving Mesothelioma has just published ... , Biomarkers are components in the blood, tissue or body fluids that ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... will join the faculty of the University of North Carolina Kenan-Flagler Business ... strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international ...
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a range ... place between the two entities said Poloz. Speaking ... Ottawa , he pointed to the country,s inflation ... federal government. "In ... "Both institutions have common economic goals, why not sit down ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle ... people with peritoneal or pleural mesothelioma. Their findings are the subject of a new ... , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma ...
Breaking Biology Technology: