Navigation Links
Stress peptide and receptor may have role in diabetes
Date:1/22/2010

LA JOLLA, CA-The neuropeptide corticotropin-releasing factor (CRF) makes cameo appearances throughout the body, but its leading role is as the opening act in the stress response, jump-starting the process along the hypothalamus-pituitary-adrenal (HPA) axis. Researchers at the Salk Institute for Biological Studies have found that CRF also plays a part in the pancreas, where it increases insulin secretion and promotes the division of the insulin-producing beta cells.

These findings, which will be published in this week's edition of the Proceedings of the National Academy of Sciences, may provide new insights into diabetes, particularly type 1, as well as suggest novel targets for drug intervention.

The pancreas is both an exocrine gland, producing enzymes that are secreted into the gut to help digest food, and an endocrine gland, secreting a cocktail of hormones, including insulin, which is manufactured by beta cells that reside in endocrine islets within the "sea" of exocrine tissue.

Plasma glucose increases after a meal, and, in healthy people, insulin is secreted to instruct the body to take up the glucose and store it in the liver or muscles to bring blood glucose levels down. In diabetes, the glucose metabolism is misregulated: In type 1 diabetes, the immune system attacks the beta cells, which then are unable to produce sufficient insulin. In type 2 diabetes, the most prevalent form of the condition, patients have sufficient beta cells, which still secrete insulin, but the body is unable to respond correctly, and plasma glucose remains constantly elevated.

CRF, in concert with its receptor, CRFR1, has long been known as key to the body's response to various forms of stress, but the pair is also involved in many more processes, including a number with direct ties to metabolism. As early as the 1980s, studies had suggested that pancreas cells can respond to CRF, but the few limited observations did not demonstrate
'/>"/>

Contact: Gina Kirchweger
kirchweger@salk.edu
885-845-341-001-340
Salk Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mice stressed in simulated weightlessness show organ atrophy
2. Heat stress influences low conception of dairy herds
3. Boston College profs study oxidative stress subcellular to discover its role in diseases
4. Researchers find evidence linking stress caused by the Sept. 11 disaster with low birth weights
5. Carnegie Mellon, Pitt Team to study psychosocial stress
6. Social stress + darkness = increased anxiety
7. Relationship between environmental stress and cancer elucidated
8. Cell response to stress signals predicts tumors in women with common pre-breast cancer
9. Asthma link to post-traumatic stress disorder, says Mailman School of Public Health study
10. Buyer beware: Stressed plants wont survive shipping
11. Moderate prenatal exposure to alcohol and stress in monkeys can cause touch sensitivity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... the Stowers Institute for Medical Research have ... and found pheromones crucial to triggering the mating process ... helps a male mouse detect pheromones that indicate when ... lets him know if the female mouse is ovulating ... critical to trigger mating. Stowers, researchers believe mice developed ...
(Date:7/25/2014)... researchers have detected an unknown interaction between microorganisms and ... into a droplet of salt water and is left ... create biomineralogical biosaline 3D morphologically complex formations, where they ... revived. The discovery was made by chance with a ... Astrobiology journal and may help to find ...
(Date:7/24/2014)... YORK, NY (July 24, 2014) Scientists at ... Institute are one step closer to creating a ... a patient,s own cells. , For the ... (iPS) cells lines from skin samples of patients ... developed an accelerated protocol to induce these stem ...
Breaking Biology News(10 mins):It takes two to court 2It takes two to court 3Bacteria manipulate salt to build shelters to hibernate 2NYSCF scientists one step closer to cell therapy for multiple sclerosis patients 2
... Age-related hearing loss (ARHL), one of the four most prevalent ... levels of folic acid, according to new research published in ... Neck Surgery . Hearing loss is a major ... between the ages of 60 and 74 dealing with the ...
... Geo-microbiologists from Arizona State University have solved a ... cyanobacteria, bore their way into limestone, sand grains, ... of carbonate. According to the lead ... the mystery of what is "at the heart ...
... Davis Health System have found that compared with healthy ... in patients in the Sacramento area with metabolic syndrome, ... one in three U.S. adults and predisposes them to ... is the first to examine vitamin-D status in patients ...
Cached Biology News:Mystery dissolves with calcium pump discovery 2Mystery dissolves with calcium pump discovery 3Study finds low vitamin-d levels in northern California residents with metabolic syndrome 2Study finds low vitamin-d levels in northern California residents with metabolic syndrome 3Study finds low vitamin-d levels in northern California residents with metabolic syndrome 4
(Date:7/25/2014)... Calif. , July 25, 2014 Amgen ... of Directors today declared a $0.61 per share dividend ... be paid on Sept. 5, 2014, to all stockholders ... Aug. 14, 2014.  About Amgen Amgen ... patients suffering from serious illnesses by discovering, developing, manufacturing ...
(Date:7/25/2014)... CAMBRIDGE, MA -- Trillions of bacteria live in each ... bacteria help digest food and stave off harmful infections, ... understood. , To help shed light on the role ... MIT associate professor Eric Alm recently tracked fluctuations in ... full year. The findings, described in the July 25 ...
(Date:7/25/2014)... University of Leicester has furthered our understanding of ... create new materials using nanosized ,building blocks,. , ... prestigious academic journal Physical Review Letters , ... rich detail the structure and internal atomic motion ... and a single helium atom. , The technique ...
(Date:7/25/2014)... 2014 Research and Markets  has ... Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study of ... new experimental technique that is being widely used ... are small molecules that are present in blood, ...
Breaking Biology Technology:Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... Calif., Oct. 11 CompareNetworks,Media Group, the leading ... industries, today announced the launch of Acuity Medical,Education, ... CompareNetworks. With the arrival of two key new ... Liza Frenzik as Special,Projects Director, the CompareNetworks team ...
... Phase 2 monotherapy trial to be initiated by end ... Biogen Idec,Inc. (Nasdaq: BIIB ) and PDL ... Phase 2 data demonstrated a significant reduction in new ... therapy in patients with active relapsing multiple,sclerosis (MS). These ...
... HAYWARD, Calif., Oct. 11 Guava Technologies today,launched ... around its,main audiences: Life Scientists, Flow Cytometrists, and ... tool for cell analysis, Guava,Technologies is dedicated to ... as possible for all life scientists and clinicians ...
Cached Biology Technology:CompareNetworks Media Group Delivers CME/CE Through Acuity Medical Education 2Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy 2Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy 3Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy 4Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy 5Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy 6New Corporate Website Launched - Focus on Life Scientists, Flow Cytometrists, & Clinicians 2
... modern flow cytometer, a scientist can resolve ... with fluorescent probes. However, the emission spectra ... labeling are broader than the light collection ... Thus, the fluorescence signal of a dye ...
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: rack ...
... ActiveSight, the leading provider of ... design, offers fragment-based screening services to ... screening involves the binding of drug-like ... crystallized protein drug targets, allowing scientists ...
...
Biology Products: